Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats

Volodymyr Shvets; Hanna Maslak; Vadim Davydov; Halyna Berest; Inna Nosulenko; Oleksii Voskoboinik; Liudmyla Omelianchyk; Oleksandr Brazhko

Makale detayları

Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats

Yazarlar:

Volodymyr Shvets | Hanna Maslak | Vadim Davydov | Halyna Berest | Inna Nosulenko | Oleksii Voskoboinik | Liudmyla Omelianchyk | Oleksandr Brazhko

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 4, pp.333-339

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001304530

pISSN:

2458-8806

Anahtar kelimeler:

Özet:

 The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old 2225 months animals. It was established, that the injection of the extract Aronia melanocarpa at a dose of 0.2 gkg 60 minutes before the immobilization has limited sensitivity of the heart muscles CPK-MT to damaging stress factors reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes, and helps the normalization of its kinetic properties, has an influence on the myocardiums kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

 The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old 2225 months animals. It was established, that the injection of the extract Aronia melanocarpa at a dose of 0.2 gkg 60 minutes before the immobilization has limited sensitivity of the heart muscles CPK-MT to damaging stress factors reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes, and helps the normalization of its kinetic properties, has an influence on the myocardiums kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

 The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old 2225 months animals. It was established, that the injection of the extract Aronia melanocarpa at a dose of 0.2 gkg 60 minutes before the immobilization has limited sensitivity of the heart muscles CPK-MT to damaging stress factors reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes, and helps the normalization of its kinetic properties, has an influence on the myocardiums kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

 The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old 2225 months animals. It was established, that the injection of the extract Aronia melanocarpa at a dose of 0.2 gkg 60 minutes before the immobilization has limited sensitivity of the heart muscles CPK-MT to damaging stress factors reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes, and helps the normalization of its kinetic properties, has an influence on the myocardiums kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

Makale detayları

Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats

Yazarlar:

Volodymyr Shvets | Hanna Maslak | Vadim Davydov | Halyna Berest | Inna Nosulenko | Oleksii Voskoboinik | Liudmyla Omelianchyk | Oleksandr Brazhko

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 4, pp.333-339

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001304530

pISSN:

2458-8806

stress

myocardium

aging

Aronia melanocarpa extract

mitochondrial creatine kinase.stress

myocardium

aging

Aronia melanocarpa extract

mitochondrial creatine kinase.

Sayı

Makale detayları

Yazarlar: Volodymyr Shvets | Hanna Maslak | Vadim Davydov | Halyna Berest | Inna Nosulenko | Oleksii Voskoboinik | Liudmyla Omelianchyk | Oleksandr Brazhko

Yayıncı: Hacettepe University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences

Dergi: Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 4, pp.333-339

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001304530

pISSN: 2458-8806

Sayı

Yazarlar:

Volodymyr Shvets | Hanna Maslak | Vadim Davydov | Halyna Berest | Inna Nosulenko | Oleksii Voskoboinik | Liudmyla Omelianchyk | Oleksandr Brazhko

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 4, pp.333-339

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001304530

pISSN:

2458-8806