Effect  Of  Nebulized  Budesonide  In  Improving  The  Clinical  Outcome  Of  Neonates  With  Meconium  Aspiration  Syndrome

Suresh RANGARAJ

Makale detayları

Effect Of Nebulized Budesonide In Improving The Clinical Outcome Of Neonates With Meconium Aspiration Syndrome

Yazarlar:

Suresh RANGARAJ

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2015 Vol.7 Issue 0

Belge Tipi:

Makale

Yayın Tarihi:

1/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000743330

Sıklık:

İki Yıllık

eISSN:

1309-1247

Özet:

 


Aim and Objective: To study the effect of nebulized steroid in improving the clinical outcome in terms of morbidity and mortality in neonates with meconium aspiration syndrome.

Design: Prospective open labeled randomized controlled trial. 

Setting: Tertiary care teaching hospital. 

Patients: Full term babies with diagnosis of meconium aspiration syndrome(MAS) admitted in the NICU of Cheluvamba Hospital attached to Mysore Medical College and Research Institute  were included in the study.

Intervention: Administration of nebulized budesonide in a dose of 50µg in 2.5ml normal saline through jet nebulizer every 12hourly from second day of life till 7days or clinical recovery whichever is earlier. 

Results: A Total of 60 patients with diagnosis of MAS were admitted to the NICU during the period of August - October 2013,out of them 20 were excluded,so a total of 40 patients were included in the study,20 in control group(Group A),20 in budesonide group (Group B). The baseline clinical profile of both the groups were similar.Duration of  respiratory distress in days (2.63 vs 5.24 p=0.0493), duration of oxygen dependency (2.37 vs 4.94 p=0.0406), duration of hospital stay (7.58 vs 10.47 p=0.0430), time taken for achievement of full feeds (3.79 vs 8.76 p=0.0002) and the need for mechanical ventilation (0 vs 0.2 p=0.0356) were statistically less in budesonide treated group as compared to the controls.Incidence of  sepsis is similar in both the groups. Complications were similar in both the groups and no specific adverse effects were  noted in the steroid treated group. Four patients died during the hospital stay,three in the control group and one in the case group .Out of them two patients died due to pneumothorax and both of them belong to the control group,other two patients died due to sepsis with disseminated intravascular coagulation(DIC), representing one each from control and case group.

Conclusion: Nebulized budesonide improves the clinical outcome in terms of  morbidity and is relatively safe,however long term follow-up is needed to recommend inhalation route of steroids as safe and effective.

.

Makale detayları

Effect Of Nebulized Budesonide In Improving The Clinical Outcome Of Neonates With Meconium Aspiration Syndrome

Yazarlar: Suresh RANGARAJ

Yayıncı: Bilal YILDIZ

Dergi: Journal of Pediatric Sciences 2015 Vol.7 Issue 0

Belge Tipi: Makale

Yayın Tarihi: 1/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000743330

Sıklık: İki Yıllık

eISSN: 1309-1247

Sayı

Yazarlar:

Suresh RANGARAJ

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2015 Vol.7 Issue 0

Belge Tipi:

Makale

Yayın Tarihi:

1/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000743330

Sıklık:

İki Yıllık

eISSN:

1309-1247