Resistance Rates of Mycobacterium tuberculosis Complex Isolates to Primary Anti-tuberculosis Drugs: A 5-Year Retrospective Study

Sondos A. A. Ibnouf; Fatma Esenkaya Taşbent

Makale detayları

Resistance Rates of Mycobacterium tuberculosis Complex Isolates to Primary Anti-tuberculosis Drugs: A 5-Year Retrospective Study

Yazarlar:

Sondos A. A. Ibnouf | Fatma Esenkaya Taşbent

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Genel Tıp Dergisi Vol.34 Issue 2, pp.190-194

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316098

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 BackgroundAim: Tuberculosis remains a major global health problem with a high morbidity and mortality rate, approximately a quarter of the population is infected with tuberculosis. Drug susceptibility testing is an essential tool for identifying and managing drug-resistant tuberculosis. This study was conducted to evaluate the drug susceptibility pattern of Mycobacterium tuberculosis complex strains isolated from a university hospital. Methods: A total of 10900 samples sent to the microbiology laboratory with the suspicion of tuberculosis clinically between January 2018 and January 2022 were analyzed retrospectively. The automated BACTEC MGIT 960 Becton Dickinson, USA was used for sample culture and susceptibility testing. The obtained data were statistically analyzed with the Statistical Package for Social Sciences SPSS version 20. Results: Out of the 154 isolated positive samples, males and females constituted equal parts of the study population 50. The majority of tuberculosis cases were in the age group 5675 years 42.2, Pulmonary TB was detected in 90.3 of the patients, while extrapulmonary TB cases were observed in 9.7. As a result of susceptibility studies on positive samples, isoniazid resistance was 5.2; streptomycin resistance 1.3; ethambutol resistance was detected at a rate of 0.6, while no rifampicin resistant sample was found. Both streptomycin and isoniazid resistance were seen together in 1.3 of the samples. Conclusion: A similar resistance pattern of the first-line antituberculosis drugs was observed in other studies conducted in different provinces of Turkey. The absence of multi-drug resistant and extensively drug-resistant tuberculosis in our study indicates that the tuberculosis surveillance program implemented in our region was successful.

 BackgroundAim: Tuberculosis remains a major global health problem with a high morbidity and mortality rate, approximately a quarter of the population is infected with tuberculosis. Drug susceptibility testing is an essential tool for identifying and managing drug-resistant tuberculosis. This study was conducted to evaluate the drug susceptibility pattern of Mycobacterium tuberculosis complex strains isolated from a university hospital. Methods: A total of 10900 samples sent to the microbiology laboratory with the suspicion of tuberculosis clinically between January 2018 and January 2022 were analyzed retrospectively. The automated BACTEC MGIT 960 Becton Dickinson, USA was used for sample culture and susceptibility testing. The obtained data were statistically analyzed with the Statistical Package for Social Sciences SPSS version 20. Results: Out of the 154 isolated positive samples, males and females constituted equal parts of the study population 50. The majority of tuberculosis cases were in the age group 5675 years 42.2, Pulmonary TB was detected in 90.3 of the patients, while extrapulmonary TB cases were observed in 9.7. As a result of susceptibility studies on positive samples, isoniazid resistance was 5.2; streptomycin resistance 1.3; ethambutol resistance was detected at a rate of 0.6, while no rifampicin resistant sample was found. Both streptomycin and isoniazid resistance were seen together in 1.3 of the samples. Conclusion: A similar resistance pattern of the first-line antituberculosis drugs was observed in other studies conducted in different provinces of Turkey. The absence of multi-drug resistant and extensively drug-resistant tuberculosis in our study indicates that the tuberculosis surveillance program implemented in our region was successful.

 BackgroundAim: Tuberculosis remains a major global health problem with a high morbidity and mortality rate, approximately a quarter of the population is infected with tuberculosis. Drug susceptibility testing is an essential tool for identifying and managing drug-resistant tuberculosis. This study was conducted to evaluate the drug susceptibility pattern of Mycobacterium tuberculosis complex strains isolated from a university hospital. Methods: A total of 10900 samples sent to the microbiology laboratory with the suspicion of tuberculosis clinically between January 2018 and January 2022 were analyzed retrospectively. The automated BACTEC MGIT 960 Becton Dickinson, USA was used for sample culture and susceptibility testing. The obtained data were statistically analyzed with the Statistical Package for Social Sciences SPSS version 20. Results: Out of the 154 isolated positive samples, males and females constituted equal parts of the study population 50. The majority of tuberculosis cases were in the age group 5675 years 42.2, Pulmonary TB was detected in 90.3 of the patients, while extrapulmonary TB cases were observed in 9.7. As a result of susceptibility studies on positive samples, isoniazid resistance was 5.2; streptomycin resistance 1.3; ethambutol resistance was detected at a rate of 0.6, while no rifampicin resistant sample was found. Both streptomycin and isoniazid resistance were seen together in 1.3 of the samples. Conclusion: A similar resistance pattern of the first-line antituberculosis drugs was observed in other studies conducted in different provinces of Turkey. The absence of multi-drug resistant and extensively drug-resistant tuberculosis in our study indicates that the tuberculosis surveillance program implemented in our region was successful.

 GirişAmaç: Tüberküloz, yüksek morbidite ve mortalite oranı ile önemli bir küresel sağlık sorunu olmaya devam etmektedir ve nüfusun yaklaşık dörtte biri tüberküloz ile enfektedir. İlaç duyarlılık testleri, ilaca dirençli tüberkülozu tanımlamak ve yönetmek için önemlidir. Bu çalışmada, bir üniversite hastanesinden izole edilen Mycobacterium tuberculosis compleks suşlarının ilaca duyarlılık paterninin değerlendirilmesi amaçlanmıştır. Yöntemler: Ocak 2018-Ocak 2022 tarihleri arasında tüberküloz şüphesi ile mikrobiyoloji laboratuvarına gönderilen toplam 10900 örnek retrospektif olarak incelenmiştir. Örneklerin kültürü ve duyarlılık testleri için BACTEC MGIT 960 Becton Dickinson, ABD otomatize sistem kullanılmıştır. Elde edilen veriler Statistical Package for Social Sciences SPSS version 20 ile istatistiksel olarak analiz edilmiştir. Bulgular: Pozitif olarak bulunan 154 hastada erkek ve kadın oranı eşit olarak bulunmuştur. Tüberküloz olgularının çoğunluğu 56-75 yaş grubunda 42,2 olup, hastaların 90,3ünde akciğer tüberkülozu saptanırken, 9,7 oranında akciğer dışı tüberküloz tespit edilmiştir. Pozitif örnkelerde yapılan duyarlılık çalışmaları sonucunda izoniazid direnci 5,2; streptomisin direnci 1,3; etambutol direnci 0,6 oranında tespit edilirken, rifampisin dirençli örnek bulunmamıştır. Örneklerin 1,3ünde hem streptomisin hem de izoniazid direnci birlikte görülmüştür. Sonuç: Türkiyede farklı illerde yapılan diğer çalışmalarda birinci basamak antitüberküloz ilaçlarda benzer direnç paterni gözlenmiştir. Çalışmamızda çok ilaca dirençli tüberküloz ve yaygın ilaca dirençli tüberküloz suşlarının bulunmaması, bölgemizde uygulanan tüberküloz sürveyans programınının başarılı olduğunu göstermektedir.

Makale detayları

Resistance Rates of Mycobacterium tuberculosis Complex Isolates to Primary Anti-tuberculosis Drugs: A 5-Year Retrospective Study

Yazarlar:

Sondos A. A. Ibnouf | Fatma Esenkaya Taşbent

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Genel Tıp Dergisi Vol.34 Issue 2, pp.190-194

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316098

pISSN:

2602-3741

Mycobacterium tuberculosis complex

tuberculosis

anti-tuberculosis drug

drug susceptibility testing.Mycobacterium tuberculosis complex

tuberculosis

anti-tuberculosis drug

drug susceptibility testing.

Sayı

Makale detayları

Yazarlar: Sondos A. A. Ibnouf | Fatma Esenkaya Taşbent

Yayıncı: Selcuk University

Ana Başlıklar: Klinik Mikrobiyoloji

Dergi: Genel Tıp Dergisi Vol.34 Issue 2, pp.190-194

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001316098

pISSN: 2602-3741

Sayı

Yazarlar:

Sondos A. A. Ibnouf | Fatma Esenkaya Taşbent

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Genel Tıp Dergisi Vol.34 Issue 2, pp.190-194

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316098

pISSN:

2602-3741