Investigation of the Effect of Serum IL-1β Levels on Atherosclerosis: A Turkish Population-Based Study

Dilveen Dlawer Omer; Fatma Tuba Akdeniz; Seda Güleç; Zerrin Barut; Deryanaz Billur; Ayça Türer Cabbar; Turgay İsbir

Makale detayları

Investigation of the Effect of Serum IL-1β Levels on Atherosclerosis: A Turkish Population-Based Study

Yazarlar:

Dilveen Dlawer Omer | Fatma Tuba Akdeniz | Seda Güleç | Zerrin Barut | Deryanaz Billur | Ayça Türer Cabbar | Turgay İsbir

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 2, pp.142-147

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298768

pISSN:

2667-5846

Anahtar kelimeler:

Özet:

 Objective: Atherosclerosis, as a cardiovascular disease associated with chronic inflammatory conditions and involving a large number of risk factors, harbors a lot of unknowns. Evidence has emerged that almost all stages of the disease are intertwined with inflammation. It has not been fully elucidated in which stages and how interleukin-1 beta IL-1β, which is associated with inflammations, plays a role in the chronic inflammatory process of the disease. Also, the effect on atherosclerosis progression and biomarker candidacy of IL-1β in the Turkish population is unknown. The aim of this study was to investigate the serum IL-1β expression levels and whether it is associated with changes in risk factors that develop due to the disease in the Turkish population. Materials and Methods: ELISA method was used to analyze the serum IL-1β levels. Statistical data was obtained utilizing the SPSS v.23 software. Results: No linkage evidence was found between the serum IL-1β and atherosclerosis p0.05. However, the serum IL-1β levels were significantly associated with gender, smoking status, and diabetes history within the study population were significantly associated p0.050. According to the lipid profile result, the triglyceride value was found to be significantly decreased in atherosclerosis patients when compared to healthy individuals p0.012. Additionally, factors including, gender, smoking status, and history of diabetes were significantly associated with serum cholesterol level p0.015. Conclusion: Although no correlation was found between the serum IL-1β levels of the study groups, it was observed that the serum IL-1β expression alters in patients with atherosclerosis depending on age. In addition, low triglyceride levels may be a marker of disease in atherosclerosis patients. Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.

 Objective: Atherosclerosis, as a cardiovascular disease associated with chronic inflammatory conditions and involving a large number of risk factors, harbors a lot of unknowns. Evidence has emerged that almost all stages of the disease are intertwined with inflammation. It has not been fully elucidated in which stages and how interleukin-1 beta IL-1β, which is associated with inflammations, plays a role in the chronic inflammatory process of the disease. Also, the effect on atherosclerosis progression and biomarker candidacy of IL-1β in the Turkish population is unknown. The aim of this study was to investigate the serum IL-1β expression levels and whether it is associated with changes in risk factors that develop due to the disease in the Turkish population. Materials and Methods: ELISA method was used to analyze the serum IL-1β levels. Statistical data was obtained utilizing the SPSS v.23 software. Results: No linkage evidence was found between the serum IL-1β and atherosclerosis p0.05. However, the serum IL-1β levels were significantly associated with gender, smoking status, and diabetes history within the study population were significantly associated p0.050. According to the lipid profile result, the triglyceride value was found to be significantly decreased in atherosclerosis patients when compared to healthy individuals p0.012. Additionally, factors including, gender, smoking status, and history of diabetes were significantly associated with serum cholesterol level p0.015. Conclusion: Although no correlation was found between the serum IL-1β levels of the study groups, it was observed that the serum IL-1β expression alters in patients with atherosclerosis depending on age. In addition, low triglyceride levels may be a marker of disease in atherosclerosis patients. Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.

 Objective: Atherosclerosis, as a cardiovascular disease associated with chronic inflammatory conditions and involving a large number of risk factors, harbors a lot of unknowns. Evidence has emerged that almost all stages of the disease are intertwined with inflammation. It has not been fully elucidated in which stages and how interleukin-1 beta IL-1β, which is associated with inflammations, plays a role in the chronic inflammatory process of the disease. Also, the effect on atherosclerosis progression and biomarker candidacy of IL-1β in the Turkish population is unknown. The aim of this study was to investigate the serum IL-1β expression levels and whether it is associated with changes in risk factors that develop due to the disease in the Turkish population. Materials and Methods: ELISA method was used to analyze the serum IL-1β levels. Statistical data was obtained utilizing the SPSS v.23 software. Results: No linkage evidence was found between the serum IL-1β and atherosclerosis p0.05. However, the serum IL-1β levels were significantly associated with gender, smoking status, and diabetes history within the study population were significantly associated p0.050. According to the lipid profile result, the triglyceride value was found to be significantly decreased in atherosclerosis patients when compared to healthy individuals p0.012. Additionally, factors including, gender, smoking status, and history of diabetes were significantly associated with serum cholesterol level p0.015. Conclusion: Although no correlation was found between the serum IL-1β levels of the study groups, it was observed that the serum IL-1β expression alters in patients with atherosclerosis depending on age. In addition, low triglyceride levels may be a marker of disease in atherosclerosis patients. Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.

 Objective: Atherosclerosis, as a cardiovascular disease associated with chronic inflammatory conditions and involving a large number of risk factors, harbors a lot of unknowns. Evidence has emerged that almost all stages of the disease are intertwined with inflammation. It has not been fully elucidated in which stages and how interleukin-1 beta IL-1β, which is associated with inflammations, plays a role in the chronic inflammatory process of the disease. Also, the effect on atherosclerosis progression and biomarker candidacy of IL-1β in the Turkish population is unknown. The aim of this study was to investigate the serum IL-1β expression levels and whether it is associated with changes in risk factors that develop due to the disease in the Turkish population. Materials and Methods: ELISA method was used to analyze the serum IL-1β levels. Statistical data was obtained utilizing the SPSS v.23 software. Results: No linkage evidence was found between the serum IL-1β and atherosclerosis p0.05. However, the serum IL-1β levels were significantly associated with gender, smoking status, and diabetes history within the study population were significantly associated p0.050. According to the lipid profile result, the triglyceride value was found to be significantly decreased in atherosclerosis patients when compared to healthy individuals p0.012. Additionally, factors including, gender, smoking status, and history of diabetes were significantly associated with serum cholesterol level p0.015. Conclusion: Although no correlation was found between the serum IL-1β levels of the study groups, it was observed that the serum IL-1β expression alters in patients with atherosclerosis depending on age. In addition, low triglyceride levels may be a marker of disease in atherosclerosis patients. Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.

Makale detayları

Investigation of the Effect of Serum IL-1β Levels on Atherosclerosis: A Turkish Population-Based Study

Yazarlar:

Dilveen Dlawer Omer | Fatma Tuba Akdeniz | Seda Güleç | Zerrin Barut | Deryanaz Billur | Ayça Türer Cabbar | Turgay İsbir

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 2, pp.142-147

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298768

pISSN:

2667-5846

Atherosclerosis

inflammation

IL-1β

triglyceride

lipid level

serum

Sayı

Makale detayları

Investigation of the Effect of Serum IL-1β Levels on Atherosclerosis: A Turkish Population-Based Study

Yazarlar: Dilveen Dlawer Omer | Fatma Tuba Akdeniz | Seda Güleç | Zerrin Barut | Deryanaz Billur | Ayça Türer Cabbar | Turgay İsbir

Yayıncı: Istanbul University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Experimed Vol.13 Issue 2, pp.142-147

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001298768

pISSN: 2667-5846

Atherosclerosis

inflammation

IL-1β

triglyceride

lipid level

serum

Sayı

Yazarlar:

Dilveen Dlawer Omer | Fatma Tuba Akdeniz | Seda Güleç | Zerrin Barut | Deryanaz Billur | Ayça Türer Cabbar | Turgay İsbir

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 2, pp.142-147

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298768

pISSN:

2667-5846