Effects of Excess Vitamin B6 Intake on Serum Lipid Profile and Cerebral Cortex in Rats

Göksemin ACAR

Makale detayları

Effects of Excess Vitamin B6 Intake on Serum Lipid Profile and Cerebral Cortex in Rats

Yazarlar:

Göksemin ACAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2006 Vol.36 Issue 6, pp.327-335

Belge Tipi:

Makale

Yayın Tarihi:

5/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000756095

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Aim: The present study was undertaken to investigate the effects of dietary excess of vitamin B6 on certain blood parameters [serum total cholesterol, high density lipoprotein (HDL) cholesterol and total lipid] and the cerebral cortex.   Materials and Methods: A total of 36 albino rats were included in the study. Saline solution was administered to control groups (CG-10, n = 6 for 10 days; CG-15, n = 6 for 15 days; CG-20, n = 6 for 20 days). The experimental groups (EG-10, n = 6; EG-15, n = 6; EG-20, n = 6) received 5 mg/kg vitamin B6 daily for 10 days, 15 days and 20 days, respectively. Serum total cholesterol, HDL cholesterol and total lipid levels were measured and compared in CGs and EGs. The cerebral cortex tissue samples were examined by electron microscopy.   Results: The total serum cholesterol levels were significantly lower (P < 0.05) although serum HDL levels were significantly higher (P < 0.01) in all EGs. Total serum lipid levels were higher in EG-15 and EG-20 groups than in CGs. The structural degenerations in the perikaryon and neuropil were found prominent in EG-15 and EG-20 groups but not in EG-10. Marked damage in the neuronal and neuropilic structure was observed in rats who received long-term high doses of vitamin B6. Based on these results, a relationship between cerebral cortex damage and serum total lipid and HDL levels in the EG-15 and EG-20 groups is suggested.   Conclusions: Dietary excess of vitamin B6 intake reduces serum total cholesterol levels, but not serum HDL and total lipid levels, and also causes cerebral cortex damage in long-term treatment. Thus, a careful diet plan and monitoring of vitamin B6 dose are recommended in patients who are supplemented with this vitamin.

 

Aim: The present study was undertaken to investigate the effects of dietary excess of vitamin B6 on certain blood parameters [serum total cholesterol, high density lipoprotein (HDL) cholesterol and total lipid] and the cerebral cortex.   Materials and Methods: A total of 36 albino rats were included in the study. Saline solution was administered to control groups (CG-10, n = 6 for 10 days; CG-15, n = 6 for 15 days; CG-20, n = 6 for 20 days). The experimental groups (EG-10, n = 6; EG-15, n = 6; EG-20, n = 6) received 5 mg/kg vitamin B6 daily for 10 days, 15 days and 20 days, respectively. Serum total cholesterol, HDL cholesterol and total lipid levels were measured and compared in CGs and EGs. The cerebral cortex tissue samples were examined by electron microscopy.   Results: The total serum cholesterol levels were significantly lower (P < 0.05) although serum HDL levels were significantly higher (P < 0.01) in all EGs. Total serum lipid levels were higher in EG-15 and EG-20 groups than in CGs. The structural degenerations in the perikaryon and neuropil were found prominent in EG-15 and EG-20 groups but not in EG-10. Marked damage in the neuronal and neuropilic structure was observed in rats who received long-term high doses of vitamin B6. Based on these results, a relationship between cerebral cortex damage and serum total lipid and HDL levels in the EG-15 and EG-20 groups is suggested.   Conclusions: Dietary excess of vitamin B6 intake reduces serum total cholesterol levels, but not serum HDL and total lipid levels, and also causes cerebral cortex damage in long-term treatment. Thus, a careful diet plan and monitoring of vitamin B6 dose are recommended in patients who are supplemented with this vitamin.

Makale detayları

Effects of Excess Vitamin B6 Intake on Serum Lipid Profile and Cerebral Cortex in Rats

Yazarlar: Göksemin ACAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2006 Vol.36 Issue 6, pp.327-335

Belge Tipi: Makale

Yayın Tarihi: 5/2006

Belge Dili: Türkçe

Document ID (Org No.): 2000756095

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Vitamin B6

blood

cholesterol

rat

cerebral cortex

Sayı

Yazarlar:

Göksemin ACAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2006 Vol.36 Issue 6, pp.327-335

Belge Tipi:

Makale

Yayın Tarihi:

5/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000756095

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144