Synergistic Antiproliferative Impact of Capsaicin and Leflunomide in Murine Lung Cancer Cells

Aybike Sarıoğlu Bozkurt

Makale detayları

Synergistic Antiproliferative Impact of Capsaicin and Leflunomide in Murine Lung Cancer Cells

Yazarlar:

Aybike Sarıoğlu Bozkurt

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Veterinary Sciences (Other)

Dergi:

Journal of Research in Veterinary Medicine Vol.44 Issue 1, pp.35-41

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355593

pISSN:

2667-6745

Anahtar kelimeler:

Özet:

 Cancer remains a major global health issue, with resistance to conventional therapies driving the need for novel treatment strategies. This study investigated the synergistic effects of capsaicin CAP, a natural bioactive compound, and Leflunomide LEF, an immunosuppressive drug, in a murine lung cancer cell line. Capsaicin activates TRPV1 receptors, increasing intracellular calcium levels, while Leflunomide inhibits Dihydroorotate Dehydrogenase DHODH, disrupting pyrimidine biosynthesis. Although neither agent exhibited significant cytotoxicity at low doses when applied individually, their combination resulted in a synergistic induction of cell death. These findings suggest that the combination of capsaicin and Leflunomide effectively limits cancer cell adaptation through metabolic and oxidative stress pathways, offering a promising anticancer mechanism. The results highlight the potential of this combination therapy for aggressive tumors such as lung cancer, emphasizing the need for further preclinical and clinical investigations.

 Cancer remains a major global health issue, with resistance to conventional therapies driving the need for novel treatment strategies. This study investigated the synergistic effects of capsaicin CAP, a natural bioactive compound, and Leflunomide LEF, an immunosuppressive drug, in a murine lung cancer cell line. Capsaicin activates TRPV1 receptors, increasing intracellular calcium levels, while Leflunomide inhibits Dihydroorotate Dehydrogenase DHODH, disrupting pyrimidine biosynthesis. Although neither agent exhibited significant cytotoxicity at low doses when applied individually, their combination resulted in a synergistic induction of cell death. These findings suggest that the combination of capsaicin and Leflunomide effectively limits cancer cell adaptation through metabolic and oxidative stress pathways, offering a promising anticancer mechanism. The results highlight the potential of this combination therapy for aggressive tumors such as lung cancer, emphasizing the need for further preclinical and clinical investigations.

 Cancer remains a major global health issue, with resistance to conventional therapies driving the need for novel treatment strategies. This study investigated the synergistic effects of capsaicin CAP, a natural bioactive compound, and Leflunomide LEF, an immunosuppressive drug, in a murine lung cancer cell line. Capsaicin activates TRPV1 receptors, increasing intracellular calcium levels, while Leflunomide inhibits Dihydroorotate Dehydrogenase DHODH, disrupting pyrimidine biosynthesis. Although neither agent exhibited significant cytotoxicity at low doses when applied individually, their combination resulted in a synergistic induction of cell death. These findings suggest that the combination of capsaicin and Leflunomide effectively limits cancer cell adaptation through metabolic and oxidative stress pathways, offering a promising anticancer mechanism. The results highlight the potential of this combination therapy for aggressive tumors such as lung cancer, emphasizing the need for further preclinical and clinical investigations.

 Cancer remains a major global health issue, with resistance to conventional therapies driving the need for novel treatment strategies. This study investigated the synergistic effects of capsaicin CAP, a natural bioactive compound, and Leflunomide LEF, an immunosuppressive drug, in a murine lung cancer cell line. Capsaicin activates TRPV1 receptors, increasing intracellular calcium levels, while Leflunomide inhibits Dihydroorotate Dehydrogenase DHODH, disrupting pyrimidine biosynthesis. Although neither agent exhibited significant cytotoxicity at low doses when applied individually, their combination resulted in a synergistic induction of cell death. These findings suggest that the combination of capsaicin and Leflunomide effectively limits cancer cell adaptation through metabolic and oxidative stress pathways, offering a promising anticancer mechanism. The results highlight the potential of this combination therapy for aggressive tumors such as lung cancer, emphasizing the need for further preclinical and clinical investigations.

Makale detayları

Synergistic Antiproliferative Impact of Capsaicin and Leflunomide in Murine Lung Cancer Cells

Yazarlar:

Aybike Sarıoğlu Bozkurt

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Veterinary Sciences (Other)

Dergi:

Journal of Research in Veterinary Medicine Vol.44 Issue 1, pp.35-41

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355593

pISSN:

2667-6745

Lung cancer

Capsaicin

Leflunomide

Synergistic effect

Combination therapy

Sayı

Makale detayları

Synergistic Antiproliferative Impact of Capsaicin and Leflunomide in Murine Lung Cancer Cells

Yazarlar: Aybike Sarıoğlu Bozkurt

Yayıncı: Bursa Uludağ University

Ana Başlıklar: Veterinary Sciences (Other)

Dergi: Journal of Research in Veterinary Medicine Vol.44 Issue 1, pp.35-41

Belge Tipi: Makale

Yayın Tarihi: 7/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001355593

pISSN: 2667-6745

Lung cancer

Capsaicin

Leflunomide

Synergistic effect

Combination therapy

Sayı

Yazarlar:

Aybike Sarıoğlu Bozkurt

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Veterinary Sciences (Other)

Dergi:

Journal of Research in Veterinary Medicine Vol.44 Issue 1, pp.35-41

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355593

pISSN:

2667-6745