Evaluation of Von Willebrand Disease in Women with Menorrhagia: Insights from a Cohort Study

Sebile Güler Çekiç; Merve Aldıkaçtıoğlu Talmaç; İbrahim Polat

Makale detayları

Evaluation of Von Willebrand Disease in Women with Menorrhagia: Insights from a Cohort Study

Yazarlar:

Sebile Güler Çekiç | Merve Aldıkaçtıoğlu Talmaç | İbrahim Polat

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

İç Hastalıkları | Klinik Tıp Bilimleri (Diğer)

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.12 Issue 2, pp.179-183

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357180

pISSN:

2148-8118

Anahtar kelimeler:

Özet:

 This study aimed to evaluate the prevalence of von Willebrand disease VWD among women presenting with menorrhagia and to assess the diagnostic utility of the VWD simple screening tool. A prospective cohort study was conducted involving 70 women, aged 1848 years, who presented to gynecology clinics with complaints of menorrhagia. Patients were administered an 8-question screening tool, routine tests and underwent further testing for von Willebrand factor antigen VWF:Ag and ristocetin cofactor activity VWF:RCo. Hematologic and coagulation parameters, including hemoglobin, ferritin, activated partial thromboplastin time and prothrombin time were compared between the groups. Of the 70 patients, 22 31 were prediagnosed with VWD based on low VWF:Ag and VWF:RCo levels. The VWD group had a higher body mass index 31.193.74 vs. 28.205.36 kgm², p0.05, higher parity 4 vs. 3, p0.05, and slightly elevated activated partial thromboplastin time levels 26.9 vs. 25.5 seconds, p0.05 compared to the control group. Hemoglobin, ferritin, and other hematologic parameters were similar between the groups. Using the method applied in this study, 31 of patients with menorrhagia were suspected to have von Willebrand disease, a higher prevalence than reported in other studies. While the VWD simple screening tool was effective in identifying patients with menorrhagia, it fell short in accurately distinguishing those with VWD. Larger prospective studies are needed to enhance the diagnosis of VWD in menorrhagia patients and to better determine its true prevalence.

 This study aimed to evaluate the prevalence of von Willebrand disease VWD among women presenting with menorrhagia and to assess the diagnostic utility of the VWD simple screening tool. A prospective cohort study was conducted involving 70 women, aged 1848 years, who presented to gynecology clinics with complaints of menorrhagia. Patients were administered an 8-question screening tool, routine tests and underwent further testing for von Willebrand factor antigen VWF:Ag and ristocetin cofactor activity VWF:RCo. Hematologic and coagulation parameters, including hemoglobin, ferritin, activated partial thromboplastin time and prothrombin time were compared between the groups. Of the 70 patients, 22 31 were prediagnosed with VWD based on low VWF:Ag and VWF:RCo levels. The VWD group had a higher body mass index 31.193.74 vs. 28.205.36 kgm², p0.05, higher parity 4 vs. 3, p0.05, and slightly elevated activated partial thromboplastin time levels 26.9 vs. 25.5 seconds, p0.05 compared to the control group. Hemoglobin, ferritin, and other hematologic parameters were similar between the groups. Using the method applied in this study, 31 of patients with menorrhagia were suspected to have von Willebrand disease, a higher prevalence than reported in other studies. While the VWD simple screening tool was effective in identifying patients with menorrhagia, it fell short in accurately distinguishing those with VWD. Larger prospective studies are needed to enhance the diagnosis of VWD in menorrhagia patients and to better determine its true prevalence.

 This study aimed to evaluate the prevalence of von Willebrand disease VWD among women presenting with menorrhagia and to assess the diagnostic utility of the VWD simple screening tool. A prospective cohort study was conducted involving 70 women, aged 1848 years, who presented to gynecology clinics with complaints of menorrhagia. Patients were administered an 8-question screening tool, routine tests and underwent further testing for von Willebrand factor antigen VWF:Ag and ristocetin cofactor activity VWF:RCo. Hematologic and coagulation parameters, including hemoglobin, ferritin, activated partial thromboplastin time and prothrombin time were compared between the groups. Of the 70 patients, 22 31 were prediagnosed with VWD based on low VWF:Ag and VWF:RCo levels. The VWD group had a higher body mass index 31.193.74 vs. 28.205.36 kgm², p0.05, higher parity 4 vs. 3, p0.05, and slightly elevated activated partial thromboplastin time levels 26.9 vs. 25.5 seconds, p0.05 compared to the control group. Hemoglobin, ferritin, and other hematologic parameters were similar between the groups. Using the method applied in this study, 31 of patients with menorrhagia were suspected to have von Willebrand disease, a higher prevalence than reported in other studies. While the VWD simple screening tool was effective in identifying patients with menorrhagia, it fell short in accurately distinguishing those with VWD. Larger prospective studies are needed to enhance the diagnosis of VWD in menorrhagia patients and to better determine its true prevalence.

 Çalışmanın amacı, menoraji şikayetiyle gelen kadınlarda von Willebrand hastalığının VWD yaygınlığını değerlendirmek, VWD basit tarama ölçeğinin tanısal faydasını değerlendirmektir. Çalışma, menoraji şikayeti ile jinekoloji polikliniklerine başvuran 18-48 yaş aralığındaki kadınlarda yürütülen prospektif kohort araştırmadır. Çalışmaya 70 hasta dahil edilmiş olup hastalara 8 soruluk bir VWD basit tarama ölçeği, rutin testler ve von Willebrand faktör antijeni VWF:Ag ve ristocetin kofaktör aktivitesi VWF:RCo testleri uygulanmıştır. Hemoglobin, ferritin, aktive parsiyel tromboplastin zamanı ve protrombin zamanı dahil olmak üzere hematolojik ve pıhtılaşma parametreleri değerlendirildi. Dahil edilen 70 hastanın 22sinde 31 azalmış VWF:Ag ve VWF:RCo seviyelerine dayanarak VWD öntanısı konuldu. VWD grubunun kontrol grubuna kıyasla daha yüksek vücut kitle indeksi 31.193.74 ve 28.205.36 kgm², p0.05, daha yüksek doğum sayısı 4e karşı 3, p0,05 ve hafif yüksek aktive parsiyel tromboplastin zamanı seviyeleri 26.9 ve 25.5 saniye, p0.05 saptandı. Hemoglobin, ferritin ve diğer hematolojik parametreler gruplar arasında benzerdi. Çalışmada kullanılan yöntem ile VWD şüphesi, menorajisi olan hastaların 31inde tespit edildi, bu diğer çalışmalardan elde edilen bulgulara kıyasla daha yüksek bir değerdir. VWD basit tarama ölçeği menorojili hastaların seçiminde faydalı ancak VWD ayrımını yapmada yetersiz kalmıştır. Menorajisi olan hastalarda VWD tanısının iyileştirilmesi ve gerçek yaygınlığının saptanması için daha büyük ölçekli prospektif araştırmalar gereklidir.

Makale detayları

Evaluation of Von Willebrand Disease in Women with Menorrhagia: Insights from a Cohort Study

Yazarlar:

Sebile Güler Çekiç | Merve Aldıkaçtıoğlu Talmaç | İbrahim Polat

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

İç Hastalıkları | Klinik Tıp Bilimleri (Diğer)

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.12 Issue 2, pp.179-183

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357180

pISSN:

2148-8118

Abnormal uterine bleeding

Menorrhagia

von Willebrand DiseaseAnormal Uterin Kanama

Menoraji

von Willebrand Hastalığı

Sayı

Makale detayları

Evaluation of Von Willebrand Disease in Women with Menorrhagia: Insights from a Cohort Study

Yazarlar: Sebile Güler Çekiç | Merve Aldıkaçtıoğlu Talmaç | İbrahim Polat

Yayıncı: Mugla Sitki Kocman University

Ana Başlıklar: İç Hastalıkları | Klinik Tıp Bilimleri (Diğer)

Dergi: Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.12 Issue 2, pp.179-183

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357180

pISSN: 2148-8118

Abnormal uterine bleeding

Menorrhagia

von Willebrand DiseaseAnormal Uterin Kanama

Menoraji

von Willebrand Hastalığı

Sayı

Yazarlar:

Sebile Güler Çekiç | Merve Aldıkaçtıoğlu Talmaç | İbrahim Polat

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

İç Hastalıkları | Klinik Tıp Bilimleri (Diğer)

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.12 Issue 2, pp.179-183

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357180

pISSN:

2148-8118