THE PREDICTIVE EFFECT OF NEUTROPHIL AND PLATELET LYMPHOCYTE RATIOS ON MICROSCOPIC SENTINEL LYMPH NODE METASTASES IN STAGE 2 MALIGNANT MELANOMA PATIENTS

Erol Kozanoğlu; Bora Akalın; Dicle Aksoyler; Ömer Berköz; Alirza Jahangirov; Tarıkcan Kumbaşı; Ufuk Emekli; Atilla Arıncı

Makale detayları

THE PREDICTIVE EFFECT OF NEUTROPHIL AND PLATELET LYMPHOCYTE RATIOS ON MICROSCOPIC SENTINEL LYMPH NODE METASTASES IN STAGE 2 MALIGNANT MELANOMA PATIENTS

Yazarlar:

Erol Kozanoğlu | Bora Akalın | Dicle Aksoyler | Ömer Berköz | Alirza Jahangirov | Tarıkcan Kumbaşı | Ufuk Emekli | Atilla Arıncı

Yayıncı:

Istanbul University

Ana Başlıklar:

Plastic Reconstructive and Aesthetic Surgery

Dergi:

Journal of Advanced Research in Health Sciences Vol.7 Issue 2, pp.68-72

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330848

pISSN:

2651-4060

Anahtar kelimeler:

Özet:

 Objective: Malignant melanoma is a life-threatening disease, and the stage affects both treatment and survival. Staging is based on the microscopic Breslow thickness of the tumor, ulceration, and lymph node status. This study compares the neutrophil and platelet lymphocyte ratios of patients with and without micrometastatic sentinel lymph nodes and assesses the predictive value of these ratios. Materials and Methods: The study includes patients who had a sentinel lymph node biopsy between January 2017 and December 2021 that resulted in a T value of T2b or T3a with neither any regional lymph node metastasis N0 nor any systemic metastasis M0. These patients were diagnosed with Stage 2A melanoma. The study evaluates the relationships patients sentinel lymph node status and gender have with their neutrophil and platelet lymphocyte ratios. Results: The study includes 65 patients, 24 of who are female and 41 of whom are male. The mean age is 55.58 years Range  18 to 87. The neutrophil, lymphocyte, and platelet counts and neutrophil and platelet lymphocyte ratio NLR and PLR did not significantly differ between the patients with and those without micrometastasis p0.05. The difference showed no significance whether adjusting for age and gender. A significant difference was found between the patients with and those without micrometastasis with respect to gender p0.009, with the percentage of males being significantly higher in the patients with micrometastasis. Conclusion: Neutrophil and platelet lymphocyte ratios have not been found to be independent predictors of sentinel lymph node micrometastasis in Stage 2A malignant melanoma, with male patients in this stage having a higher risk of sentinel lymph node micrometastasis.

 Objective: Malignant melanoma is a life-threatening disease, and the stage affects both treatment and survival. Staging is based on the microscopic Breslow thickness of the tumor, ulceration, and lymph node status. This study compares the neutrophil and platelet lymphocyte ratios of patients with and without micrometastatic sentinel lymph nodes and assesses the predictive value of these ratios. Materials and Methods: The study includes patients who had a sentinel lymph node biopsy between January 2017 and December 2021 that resulted in a T value of T2b or T3a with neither any regional lymph node metastasis N0 nor any systemic metastasis M0. These patients were diagnosed with Stage 2A melanoma. The study evaluates the relationships patients sentinel lymph node status and gender have with their neutrophil and platelet lymphocyte ratios. Results: The study includes 65 patients, 24 of who are female and 41 of whom are male. The mean age is 55.58 years Range  18 to 87. The neutrophil, lymphocyte, and platelet counts and neutrophil and platelet lymphocyte ratio NLR and PLR did not significantly differ between the patients with and those without micrometastasis p0.05. The difference showed no significance whether adjusting for age and gender. A significant difference was found between the patients with and those without micrometastasis with respect to gender p0.009, with the percentage of males being significantly higher in the patients with micrometastasis. Conclusion: Neutrophil and platelet lymphocyte ratios have not been found to be independent predictors of sentinel lymph node micrometastasis in Stage 2A malignant melanoma, with male patients in this stage having a higher risk of sentinel lymph node micrometastasis.

 Objective: Malignant melanoma is a life-threatening disease, and the stage affects both treatment and survival. Staging is based on the microscopic Breslow thickness of the tumor, ulceration, and lymph node status. This study compares the neutrophil and platelet lymphocyte ratios of patients with and without micrometastatic sentinel lymph nodes and assesses the predictive value of these ratios. Materials and Methods: The study includes patients who had a sentinel lymph node biopsy between January 2017 and December 2021 that resulted in a T value of T2b or T3a with neither any regional lymph node metastasis N0 nor any systemic metastasis M0. These patients were diagnosed with Stage 2A melanoma. The study evaluates the relationships patients sentinel lymph node status and gender have with their neutrophil and platelet lymphocyte ratios. Results: The study includes 65 patients, 24 of who are female and 41 of whom are male. The mean age is 55.58 years Range  18 to 87. The neutrophil, lymphocyte, and platelet counts and neutrophil and platelet lymphocyte ratio NLR and PLR did not significantly differ between the patients with and those without micrometastasis p0.05. The difference showed no significance whether adjusting for age and gender. A significant difference was found between the patients with and those without micrometastasis with respect to gender p0.009, with the percentage of males being significantly higher in the patients with micrometastasis. Conclusion: Neutrophil and platelet lymphocyte ratios have not been found to be independent predictors of sentinel lymph node micrometastasis in Stage 2A malignant melanoma, with male patients in this stage having a higher risk of sentinel lymph node micrometastasis.

 Amaç: Yaşamı tehdit eden bir deri kanseri olan malign melanomda hastalığın evresi tedavi yaklaşımını ve sağkalımı etkilemektedir. Malign melanomun evrelemesinde, tümörün mikroskopik olarak ölçülen Breslow kalınlığından, ülserasyondan ve olası bir lenf nodu tutulumundan faydalanılmaktadır. Bu çalışmada sentinel lenf nodu biyopsileri mikroskopik olarak metastazsız negatif ve metastazlı pozitif olan hastaların nötrofil lenfosit ve trombosit lenfosit oranları karşılaştırıldı ve bu oranların metastaz üzerinde bir öngörü etkisi olup olmadığı değerlendirildi. Gereç ve Yöntem: Ocak 2017Aralık 2021 tarihleri arasında sentinel lenf nodu biyopsisi ameliyatı yapılmış olan, Breslow kalınlığına göre T değeri T2b veya T3a olan, makroskopik lenf nodu metastazı olmayan N0 ve sistemik uzak metastazı da olmayan M0 evre 2A malign melanom hastaları çalışmaya dahil edildi. Sentinel lenf nodu biyopsisi durumları ile cinsiyet arasındaki ilişki ve sentinel lenf nodu biyopsisi ile nötrofil ve trombosit lenfosit oranları arasındaki ilişki değerlendirildi. Bulgular: Çalışmaya 65 hasta dahil edildi. Hastaların 24ü kadın, 41I erkekti. Hastaların ortalama yaşı 55,58 idi 1887. Yaş ve cinsiyete göre düzeltme yapmadan ve yapılarak gerçekleştirilen değerlendirmeler sonucunda mikrometastaz açısından nötrofil, lenfosit, platelet sayıları, nötrofil lenfosit oranı NLO ve platelet lenfosit oranları PLO değerleri bakımından istatistiksel olarak anlamlı fark saptanmadı p0,05. Sentinel lenf nodu biyopsisi mikrometastazı olan ve olmayan hastalar arasında cinsiyet bakımından istatistiksel olarak anlamlı fark olduğu saptandı p0,009. Mikrometastazlı grupta erkek yüzdesinin mikrometastazsız gruptan daha yüksek olduğu saptandı. Sonuç: Evre 2A malign melanom hastalarında, nötrofil ve trombosit lenfosit oranları, sentinel lenf nodundaki mikroskobik metastazı bağımsız bir değişken olarak öngörememektedir. Bu evredeki erkek hastalarda sentinel lenf nodu mikrometastazı riski kadın hastalara göre daha yüksektir.

Makale detayları

THE PREDICTIVE EFFECT OF NEUTROPHIL AND PLATELET LYMPHOCYTE RATIOS ON MICROSCOPIC SENTINEL LYMPH NODE METASTASES IN STAGE 2 MALIGNANT MELANOMA PATIENTS

Yazarlar:

Erol Kozanoğlu | Bora Akalın | Dicle Aksoyler | Ömer Berköz | Alirza Jahangirov | Tarıkcan Kumbaşı | Ufuk Emekli | Atilla Arıncı

Yayıncı:

Istanbul University

Ana Başlıklar:

Plastic Reconstructive and Aesthetic Surgery

Dergi:

Journal of Advanced Research in Health Sciences Vol.7 Issue 2, pp.68-72

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330848

pISSN:

2651-4060

malignant melanoma

micrometastasis

neutrophil lymphocyte ratio

platelet lymphocyte ratio

sentinel lymph node biopsyMalign melanoma

mikrometastaz

nötrofil lenfosit oranı

sentinel lenf nodu biyopsisi

trombosit lenfosit oranı

Sayı

Makale detayları

Yazarlar: Erol Kozanoğlu | Bora Akalın | Dicle Aksoyler | Ömer Berköz | Alirza Jahangirov | Tarıkcan Kumbaşı | Ufuk Emekli | Atilla Arıncı

Yayıncı: Istanbul University

Ana Başlıklar: Plastic Reconstructive and Aesthetic Surgery

Dergi: Journal of Advanced Research in Health Sciences Vol.7 Issue 2, pp.68-72

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330848

pISSN: 2651-4060

Sayı

Yazarlar:

Erol Kozanoğlu | Bora Akalın | Dicle Aksoyler | Ömer Berköz | Alirza Jahangirov | Tarıkcan Kumbaşı | Ufuk Emekli | Atilla Arıncı

Yayıncı:

Istanbul University

Ana Başlıklar:

Plastic Reconstructive and Aesthetic Surgery

Dergi:

Journal of Advanced Research in Health Sciences Vol.7 Issue 2, pp.68-72

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330848

pISSN:

2651-4060