Simultaneous determination of azithromycin and levo  oxacin in pharmaceuticals  by charge transfer complexation with alizarin red S using an absorption-factor  method

Vijay D. CHAVADA; Nejal M. BHATT; Mallika SANYAL; Pranav S. SHRIVASTAV

Makale detayları

Simultaneous determination of azithromycin and levo oxacin in pharmaceuticals by charge transfer complexation with alizarin red S using an absorption-factor method

Yazarlar:

Vijay D. CHAVADA | Nejal M. BHATT | Mallika SANYAL | Pranav S. SHRIVASTAV

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 1, pp.36-49

Belge Tipi:

Makale

Yayın Tarihi:

1/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000726231

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A new approach based on a selective charge transfer reaction with alizarin red S is described for the simultaneous determination of azithromycin and levo  oxacin in their binary mixtures using an absorption-factor spectrophotometric method. Native absorbance was used for the determination for levo  oxacin, while a charge transfer complexation  of alizarin red S served as the basis for the quantitation of azithromycin. The reaction of azithromycin with alizarin red  S was possible in methanol under neutral conditions within 15 min at 25  ℃. The conditions were suitably optimized  for selective complexation of azithromycin with minimal interference from levo  oxacin. The calibration curve was linear over the concentration range of 4.0–20  g mL−1 for azithromycin and levo  oxacin and the correlation coefficients  of the regression equations were consistently greater than 0.9970 for both the drugs. The limit of detection was 1.07 g mL−1 for azithromycin and 0.84 g mL−1 for levo  oxacin. The developed method was highly reproducible with  precision (RSD%) values in the range of 0.54%–0.95% for both the drugs. The method was successfully applied for the  simultaneous determination of these antibacterial drugs from their synthetic mixtures and pharmaceutical formulations  with no interference from excipients.

Makale detayları

Simultaneous determination of azithromycin and levo oxacin in pharmaceuticals by charge transfer complexation with alizarin red S using an absorption-factor method

Yazarlar: Vijay D. CHAVADA | Nejal M. BHATT | Mallika SANYAL | Pranav S. SHRIVASTAV

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2018 Vol.42 Issue 1, pp.36-49

Belge Tipi: Makale

Yayın Tarihi: 1/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000726231

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Vijay D. CHAVADA | Nejal M. BHATT | Mallika SANYAL | Pranav S. SHRIVASTAV

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 1, pp.36-49

Belge Tipi:

Makale

Yayın Tarihi:

1/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000726231

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527