Synthesis and characterization of bis(azine) ligands and metal complexes: DNA-interaction and extraction properties for metals and dichromate anions

Sultan KULAKSIZOĞLU; Cansu GÖKÇE; Ramazan GÜP

Makale detayları

Synthesis and characterization of bis(azine) ligands and metal complexes: DNA-interaction and extraction properties for metals and dichromate anions

Yazarlar:

Sultan KULAKSIZOĞLU | Cansu GÖKÇE | Ramazan GÜP

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.717-733

Belge Tipi:

Makale

Yayın Tarihi:

4/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727556

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Two new bis(bidentate) azine ligands were prepared by  linking (1Z,1'Z)-1,1'-{butane-1,4-diylbis[oxyben-zene-4,1-  diyl(1Z)eth-1-yl-1-ylidene]}dihydrazine to salicylaldehyde and  pyridine-2-carbaldehyde, 1,4-bis{4-{(1E)-1-((2E)-(2-  hydroxybenzene--2-ylmethy-lidene)hydrazonylidene)ethyl}phenoxy}butane  (H2L1), and 1,4-bis{4-{(1E)-1-((2E)-(pyridine--2-ylmethylidene)  hydrazonylidene)ethyl}phenoxy}butane (L2), respecti- vely.  Two  kinds of copper(II) and nickel(II) complexes with different ligands  were prepared.  Reaction of H2L1 with Cu(II) and Ni(II) acetate with  1:1 molar ratio gave double stranded binuclear bis(azine) complexes  with stoichiometry [M(L1)]2 containing {MIIN2O2} centers.  On the other hand, 1:1 molar ratio reaction of Cu(II) and Ni(II)  chloride with L2 yielded mononuclear metal complexes with general  stoichiometry [M(L2)Cl2] containing {MIIN2N2} centers.  The structures of both bis(azine) ligands and complexes were  identified by elemental analysis, infrared spectra, UV--Vis electronic  absorption spectra, magnetic susceptibility measurements, and TGA. DNA  binding and DNA cleavage activities of the mononuclear complexes of  L2, [M(L2)Cl2] were examined by using UV-Vis titration and agarose  gel electrophoresis, respectively.  The results indicate that  mononuclear complexes, especially [Cu(L2)Cl2], bind significantly  calf thymus DNA and cleaves pBR322 DNA. Furthermore, the complexing  properties of the bis-azine ligands toward selected transition metal  cations and dichromate anions were also reported.  It was found that  bis(azine) ligands have high extraction ability towards dichromate  anions.

 

Two new bis(bidentate) azine ligands were prepared by  linking (1Z,1'Z)-1,1'-{butane-1,4-diylbis[oxyben-zene-4,1-  diyl(1Z)eth-1-yl-1-ylidene]}dihydrazine to salicylaldehyde and  pyridine-2-carbaldehyde, 1,4-bis{4-{(1E)-1-((2E)-(2-  hydroxybenzene--2-ylmethy-lidene)hydrazonylidene)ethyl}phenoxy}butane  (H2L1), and 1,4-bis{4-{(1E)-1-((2E)-(pyridine--2-ylmethylidene)  hydrazonylidene)ethyl}phenoxy}butane (L2), respecti- vely.  Two  kinds of copper(II) and nickel(II) complexes with different ligands  were prepared.  Reaction of H2L1 with Cu(II) and Ni(II) acetate with  1:1 molar ratio gave double stranded binuclear bis(azine) complexes  with stoichiometry [M(L1)]2 containing {MIIN2O2} centers.  On the other hand, 1:1 molar ratio reaction of Cu(II) and Ni(II)  chloride with L2 yielded mononuclear metal complexes with general  stoichiometry [M(L2)Cl2] containing {MIIN2N2} centers.  The structures of both bis(azine) ligands and complexes were  identified by elemental analysis, infrared spectra, UV--Vis electronic  absorption spectra, magnetic susceptibility measurements, and TGA. DNA  binding and DNA cleavage activities of the mononuclear complexes of  L2, [M(L2)Cl2] were examined by using UV-Vis titration and agarose  gel electrophoresis, respectively.  The results indicate that  mononuclear complexes, especially [Cu(L2)Cl2], bind significantly  calf thymus DNA and cleaves pBR322 DNA. Furthermore, the complexing  properties of the bis-azine ligands toward selected transition metal  cations and dichromate anions were also reported.  It was found that  bis(azine) ligands have high extraction ability towards dichromate  anions.

Makale detayları

Synthesis and characterization of bis(azine) ligands and metal complexes: DNA-interaction and extraction properties for metals and dichromate anions

Yazarlar: Sultan KULAKSIZOĞLU | Cansu GÖKÇE | Ramazan GÜP

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.717-733

Belge Tipi: Makale

Yayın Tarihi: 4/2012

Belge Dili: Türkçe

Document ID (Org No.): 2000727556

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Sultan KULAKSIZOĞLU | Cansu GÖKÇE | Ramazan GÜP

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.717-733

Belge Tipi:

Makale

Yayın Tarihi:

4/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727556

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527