Evaluation of the physical properties of an orodispersible  tablet containing melatonin and pyridoxine HCl (Vitamin  B6)

İsmail Aslan; Ahmet Arif Kurt

Makale detayları

Evaluation of the physical properties of an orodispersible tablet containing melatonin and pyridoxine HCl (Vitamin B6)

Yazarlar:

İsmail Aslan | Ahmet Arif Kurt

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.2137-2146

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334786

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Individuals deficient in melatonin are more prone to experiencing difficulties with sleep. The creation of an orally disintegrating tablet formulation of melatonin MT would enable a rapid and efficacious response to the populations needs. This formulation is suitable for all individuals, including the elderly and children, and is also preferred due to its pleasant taste. The text in question discusses the role of pyridoxine PY as a vital coenzyme involved in a number of physiological processes within the human body. The text emphasises the necessity of obtaining pyridoxine PY from external sources, given that the body is incapable of producing it autonomously. Moreover, the text delineates the formulation of a tablet containing both MT and PY, which is designed for convenient use and enhanced efficacy. Moreover, the text delineates the exhaustive testing regimen, which encompasses weight deviation, friability, disintegration time, moisture content, diameter and height measurements, and hardness tests, to ensure the physical stability of the manufactured tablets. The aforementioned tests demonstrated that the tablet satisfied the criteria set forth in the European Pharmacopoeia. The results of the physical tests conducted on the tablet containing MT and PY demonstrated that the values obtained were within the desired range and in accordance with the standards set forth in the European Pharmacopoeia. The mean hardness of the manufactured tablets was determined to be within the range of 27  3.2 to 35  1.5 Newton. In the friability test, the efficiency ratio was calculated to be 99.793. It is a widely accepted principle that the diameter and thickness of tablets should be 14. The results demonstrate that all ODTs exhibit this characteristic. The tablets were found to possess both hardness and friability, which ensures that the tablet remains stable and reduces losses to a minimum. The mean diameter of the tablets was found to be 7.08  0.01 mm, with a mean height of 2.50  0.01 mm. Furthermore, the mean diameter was determined to be 6.97  0.01 mm, with a mean height of 3.21  0.01 mm. The standardisation of the tablets was successfully accomplished. The disintegration test yielded an average disintegration time of between 20 and 28 seconds for the tablets in the oral cavity, which was deemed optimal. In conclusion, the text suggests that further evaluation through in vivo and in vitro tests could be conducted to further develop the formulation.

 Individuals deficient in melatonin are more prone to experiencing difficulties with sleep. The creation of an orally disintegrating tablet formulation of melatonin MT would enable a rapid and efficacious response to the populations needs. This formulation is suitable for all individuals, including the elderly and children, and is also preferred due to its pleasant taste. The text in question discusses the role of pyridoxine PY as a vital coenzyme involved in a number of physiological processes within the human body. The text emphasises the necessity of obtaining pyridoxine PY from external sources, given that the body is incapable of producing it autonomously. Moreover, the text delineates the formulation of a tablet containing both MT and PY, which is designed for convenient use and enhanced efficacy. Moreover, the text delineates the exhaustive testing regimen, which encompasses weight deviation, friability, disintegration time, moisture content, diameter and height measurements, and hardness tests, to ensure the physical stability of the manufactured tablets. The aforementioned tests demonstrated that the tablet satisfied the criteria set forth in the European Pharmacopoeia. The results of the physical tests conducted on the tablet containing MT and PY demonstrated that the values obtained were within the desired range and in accordance with the standards set forth in the European Pharmacopoeia. The mean hardness of the manufactured tablets was determined to be within the range of 27  3.2 to 35  1.5 Newton. In the friability test, the efficiency ratio was calculated to be 99.793. It is a widely accepted principle that the diameter and thickness of tablets should be 14. The results demonstrate that all ODTs exhibit this characteristic. The tablets were found to possess both hardness and friability, which ensures that the tablet remains stable and reduces losses to a minimum. The mean diameter of the tablets was found to be 7.08  0.01 mm, with a mean height of 2.50  0.01 mm. Furthermore, the mean diameter was determined to be 6.97  0.01 mm, with a mean height of 3.21  0.01 mm. The standardisation of the tablets was successfully accomplished. The disintegration test yielded an average disintegration time of between 20 and 28 seconds for the tablets in the oral cavity, which was deemed optimal. In conclusion, the text suggests that further evaluation through in vivo and in vitro tests could be conducted to further develop the formulation.

 Individuals deficient in melatonin are more prone to experiencing difficulties with sleep. The creation of an orally disintegrating tablet formulation of melatonin MT would enable a rapid and efficacious response to the populations needs. This formulation is suitable for all individuals, including the elderly and children, and is also preferred due to its pleasant taste. The text in question discusses the role of pyridoxine PY as a vital coenzyme involved in a number of physiological processes within the human body. The text emphasises the necessity of obtaining pyridoxine PY from external sources, given that the body is incapable of producing it autonomously. Moreover, the text delineates the formulation of a tablet containing both MT and PY, which is designed for convenient use and enhanced efficacy. Moreover, the text delineates the exhaustive testing regimen, which encompasses weight deviation, friability, disintegration time, moisture content, diameter and height measurements, and hardness tests, to ensure the physical stability of the manufactured tablets. The aforementioned tests demonstrated that the tablet satisfied the criteria set forth in the European Pharmacopoeia. The results of the physical tests conducted on the tablet containing MT and PY demonstrated that the values obtained were within the desired range and in accordance with the standards set forth in the European Pharmacopoeia. The mean hardness of the manufactured tablets was determined to be within the range of 27  3.2 to 35  1.5 Newton. In the friability test, the efficiency ratio was calculated to be 99.793. It is a widely accepted principle that the diameter and thickness of tablets should be 14. The results demonstrate that all ODTs exhibit this characteristic. The tablets were found to possess both hardness and friability, which ensures that the tablet remains stable and reduces losses to a minimum. The mean diameter of the tablets was found to be 7.08  0.01 mm, with a mean height of 2.50  0.01 mm. Furthermore, the mean diameter was determined to be 6.97  0.01 mm, with a mean height of 3.21  0.01 mm. The standardisation of the tablets was successfully accomplished. The disintegration test yielded an average disintegration time of between 20 and 28 seconds for the tablets in the oral cavity, which was deemed optimal. In conclusion, the text suggests that further evaluation through in vivo and in vitro tests could be conducted to further develop the formulation.

 Individuals deficient in melatonin are more prone to experiencing difficulties with sleep. The creation of an orally disintegrating tablet formulation of melatonin MT would enable a rapid and efficacious response to the populations needs. This formulation is suitable for all individuals, including the elderly and children, and is also preferred due to its pleasant taste. The text in question discusses the role of pyridoxine PY as a vital coenzyme involved in a number of physiological processes within the human body. The text emphasises the necessity of obtaining pyridoxine PY from external sources, given that the body is incapable of producing it autonomously. Moreover, the text delineates the formulation of a tablet containing both MT and PY, which is designed for convenient use and enhanced efficacy. Moreover, the text delineates the exhaustive testing regimen, which encompasses weight deviation, friability, disintegration time, moisture content, diameter and height measurements, and hardness tests, to ensure the physical stability of the manufactured tablets. The aforementioned tests demonstrated that the tablet satisfied the criteria set forth in the European Pharmacopoeia. The results of the physical tests conducted on the tablet containing MT and PY demonstrated that the values obtained were within the desired range and in accordance with the standards set forth in the European Pharmacopoeia. The mean hardness of the manufactured tablets was determined to be within the range of 27  3.2 to 35  1.5 Newton. In the friability test, the efficiency ratio was calculated to be 99.793. It is a widely accepted principle that the diameter and thickness of tablets should be 14. The results demonstrate that all ODTs exhibit this characteristic. The tablets were found to possess both hardness and friability, which ensures that the tablet remains stable and reduces losses to a minimum. The mean diameter of the tablets was found to be 7.08  0.01 mm, with a mean height of 2.50  0.01 mm. Furthermore, the mean diameter was determined to be 6.97  0.01 mm, with a mean height of 3.21  0.01 mm. The standardisation of the tablets was successfully accomplished. The disintegration test yielded an average disintegration time of between 20 and 28 seconds for the tablets in the oral cavity, which was deemed optimal. In conclusion, the text suggests that further evaluation through in vivo and in vitro tests could be conducted to further develop the formulation.

Makale detayları

Evaluation of the physical properties of an orodispersible tablet containing melatonin and pyridoxine HCl (Vitamin B6)

Yazarlar:

İsmail Aslan | Ahmet Arif Kurt

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.2137-2146

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334786

pISSN:

2630-6344

Melatonin

pyridoxine (vitamin B6)

orodispersible tablet

formulation

physical analysis

Sayı

Makale detayları

Evaluation of the physical properties of an orodispersible tablet containing melatonin and pyridoxine HCl (Vitamin B6)

Yazarlar: İsmail Aslan | Ahmet Arif Kurt

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.28 Issue 6, pp.2137-2146

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001334786

pISSN: 2630-6344

Melatonin

pyridoxine (vitamin B6)

orodispersible tablet

formulation

physical analysis

Sayı

Yazarlar:

İsmail Aslan | Ahmet Arif Kurt

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.2137-2146

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334786

pISSN:

2630-6344