Microwave assisted synthesis of ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4- dihydro-2H-furo[3,2-c]chromene-3-carboxylate via manganese(III) acetate mediated radical cyclization reaction

Negar KHEZRİ; E. Vildan BURGAZ

Makale detayları

Microwave assisted synthesis of ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4- dihydro-2H-furo[3,2-c]chromene-3-carboxylate via manganese(III) acetate mediated radical cyclization reaction

Yazarlar:

Negar KHEZRİ | E. Vildan BURGAZ

Yayıncı:

Dogu Akdeniz University

Ana Başlıklar:

Organik kimya

Dergi:

EMU Journal of Pharmaceutical Sciences 2020 Vol.3 Issue 2, pp.80-85

Belge Tipi:

Makale

Yayın Tarihi:

10/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000697653

Sıklık:

Üç Yıllık

pISSN:

2651-3587

Özet:

 

“Ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” is dihydro- furan-fused monocyclic heterocycles containing dihydrofurocoumarin framework. Compounds that include these core structures are especially important for drug discovery. 
Manganese(III) acetate has been used as an efficient oxidizing agent for the preparation of “ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” by the multi-steps reaction of ethyl 3,3-bis(4-fluorophenyl)acrylate and 4-hydroxycoumarin under microwave irradiation to perform faster heating times, significantly reduce reaction times, and the efficient solubilization of manganese(III) acetate in acetic acid. The cyclization reaction was achieved using reactivity of the carbonyl group within the molecule.

Makale detayları

Microwave assisted synthesis of ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4- dihydro-2H-furo[3,2-c]chromene-3-carboxylate via manganese(III) acetate mediated radical cyclization reaction

Yazarlar: Negar KHEZRİ | E. Vildan BURGAZ

Yayıncı: Dogu Akdeniz University

Ana Başlıklar: Organik kimya

Dergi: EMU Journal of Pharmaceutical Sciences 2020 Vol.3 Issue 2, pp.80-85

Belge Tipi: Makale

Yayın Tarihi: 10/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000697653

Sıklık: Üç Yıllık

pISSN: 2651-3587

Sayı

Yazarlar:

Negar KHEZRİ | E. Vildan BURGAZ

Yayıncı:

Dogu Akdeniz University

Ana Başlıklar:

Organik kimya

Dergi:

EMU Journal of Pharmaceutical Sciences 2020 Vol.3 Issue 2, pp.80-85

Belge Tipi:

Makale

Yayın Tarihi:

10/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000697653

Sıklık:

Üç Yıllık

pISSN:

2651-3587