Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery

N.A.

Makale detayları

Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.210-218

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346119

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The purpose of this work is to develop a biodegradable calcium alginate Ca-alginate bead formulation to provide controlled release of l-cysteine Cys amino acid for oral drug delivery. Ca-alginate bead formulations were prepared successfully and reproducibly using calcium chloride as a cross-linking agent. The beads were then evaluated in terms of morphology, particle size, swellability, thermal behaviors, encapsulation efficiency, and in-vitro drug release at pH 1.2 and pH 7.4. The size of the beads was measured between 2.230.11 and 2.410.12 mm. In terms of thermal analysis, differential scanning calorimetry was utilized to ensure the encapsulation of Cys into bead formulation. Cys encapsulation was determined as 79.49 1.12. Swelling index of blank beads were found to be in a range of 0.31-0.35 in HCl solution at pH 1.2; 0.98-1.08 in PBS buffer at pH 7.4. Alginate beads exhibited controlled release, followed the Weibull model which is consistent with the swelling pattern. The physico-chemical properties of the developed formulation indicate that the formulation is suitable for oral Cys delivery.

 The purpose of this work is to develop a biodegradable calcium alginate Ca-alginate bead formulation to provide controlled release of l-cysteine Cys amino acid for oral drug delivery. Ca-alginate bead formulations were prepared successfully and reproducibly using calcium chloride as a cross-linking agent. The beads were then evaluated in terms of morphology, particle size, swellability, thermal behaviors, encapsulation efficiency, and in-vitro drug release at pH 1.2 and pH 7.4. The size of the beads was measured between 2.230.11 and 2.410.12 mm. In terms of thermal analysis, differential scanning calorimetry was utilized to ensure the encapsulation of Cys into bead formulation. Cys encapsulation was determined as 79.49 1.12. Swelling index of blank beads were found to be in a range of 0.31-0.35 in HCl solution at pH 1.2; 0.98-1.08 in PBS buffer at pH 7.4. Alginate beads exhibited controlled release, followed the Weibull model which is consistent with the swelling pattern. The physico-chemical properties of the developed formulation indicate that the formulation is suitable for oral Cys delivery.

 The purpose of this work is to develop a biodegradable calcium alginate Ca-alginate bead formulation to provide controlled release of l-cysteine Cys amino acid for oral drug delivery. Ca-alginate bead formulations were prepared successfully and reproducibly using calcium chloride as a cross-linking agent. The beads were then evaluated in terms of morphology, particle size, swellability, thermal behaviors, encapsulation efficiency, and in-vitro drug release at pH 1.2 and pH 7.4. The size of the beads was measured between 2.230.11 and 2.410.12 mm. In terms of thermal analysis, differential scanning calorimetry was utilized to ensure the encapsulation of Cys into bead formulation. Cys encapsulation was determined as 79.49 1.12. Swelling index of blank beads were found to be in a range of 0.31-0.35 in HCl solution at pH 1.2; 0.98-1.08 in PBS buffer at pH 7.4. Alginate beads exhibited controlled release, followed the Weibull model which is consistent with the swelling pattern. The physico-chemical properties of the developed formulation indicate that the formulation is suitable for oral Cys delivery.

 The purpose of this work is to develop a biodegradable calcium alginate Ca-alginate bead formulation to provide controlled release of l-cysteine Cys amino acid for oral drug delivery. Ca-alginate bead formulations were prepared successfully and reproducibly using calcium chloride as a cross-linking agent. The beads were then evaluated in terms of morphology, particle size, swellability, thermal behaviors, encapsulation efficiency, and in-vitro drug release at pH 1.2 and pH 7.4. The size of the beads was measured between 2.230.11 and 2.410.12 mm. In terms of thermal analysis, differential scanning calorimetry was utilized to ensure the encapsulation of Cys into bead formulation. Cys encapsulation was determined as 79.49 1.12. Swelling index of blank beads were found to be in a range of 0.31-0.35 in HCl solution at pH 1.2; 0.98-1.08 in PBS buffer at pH 7.4. Alginate beads exhibited controlled release, followed the Weibull model which is consistent with the swelling pattern. The physico-chemical properties of the developed formulation indicate that the formulation is suitable for oral Cys delivery.

Makale detayları

Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.210-218

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346119

pISSN:

2630-6344

Ca-alginate bead

sodium alginate

oral drug delivery

l-cysteine

controlled release

Sayı

Makale detayları

Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.26 Issue 1, pp.210-218

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346119

pISSN: 2630-6344

Ca-alginate bead

sodium alginate

oral drug delivery

l-cysteine

controlled release

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.210-218

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346119

pISSN:

2630-6344