Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors

MEHDI RIMAZ; PARIA POURHOSSEIN; BEHZAD KHALILI

doi:https://doi.org/10.3906/kim-1408-32

Makale detayları

Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors

Yazarlar:

MEHDI RIMAZ | PARIA POURHOSSEIN | BEHZAD KHALILI

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2015 Vol.39 Issue 2

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000726905

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1408-32

Özet:

 

New 3-aryl-6-methylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and  3-aryl-6-ethyl-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones were efficiently  synthesized via a regiospecific one-pot reaction of N-methylbarbituric acid  and N-ethyl-2-thiobarbituric acid with various arylglyoxal monohydrates in  the presence of hydrazine dihydrochloride in ethanol at 50 °C. The  target compounds were obtained in high yields and were regioisomerically  pure after recrystallization. These new heterocycles may act as potential  MAO_{B} inhibitors.

 

New 3-aryl-6-methylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and  3-aryl-6-ethyl-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones were efficiently  synthesized via a regiospecific one-pot reaction of N-methylbarbituric acid  and N-ethyl-2-thiobarbituric acid with various arylglyoxal monohydrates in  the presence of hydrazine dihydrochloride in ethanol at 50 °C. The  target compounds were obtained in high yields and were regioisomerically  pure after recrystallization. These new heterocycles may act as potential  MAO_{B} inhibitors.

Makale detayları

Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors

Yazarlar: MEHDI RIMAZ | PARIA POURHOSSEIN | BEHZAD KHALILI

Yayıncı: TUBITAK

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Turkish Journal of Chemistry 2015 Vol.39 Issue 2

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000726905

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1408-32

Sayı

Yazarlar:

MEHDI RIMAZ | PARIA POURHOSSEIN | BEHZAD KHALILI

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2015 Vol.39 Issue 2

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000726905

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1408-32