EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF HIDRADENITIS SUPPURATIVA PATIENTS: 10-YEAR EXPERIENCE FROM A SINGLE TERTIARY CENTER

Selda Işık Mermutlu; Zeynep Keskinkaya

Makale detayları

EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF HIDRADENITIS SUPPURATIVA PATIENTS: 10-YEAR EXPERIENCE FROM A SINGLE TERTIARY CENTER

Yazarlar:

Selda Işık Mermutlu | Zeynep Keskinkaya

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.86 Issue 3, pp.235-244

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293733

pISSN:

1305-6441

Anahtar kelimeler:

Özet:

 Objective: To investigate the clinico-epidemiological profile of hidradenitis suppurativa HS patients. Material and Method: In this retrospective cross-sectional single tertiary center study, the HS patients diagnosed andor followed up between 2012-2022 were evaluated regarding demographic features, clinical findings, associated comorbidities, therapies initiated for HS and their outcomes. Results: Of 101 HS patients male:female ratio1.7:1, 23.3 n20 had a history of early-onset disease 18 years. The majority had no family history of HS 82.7, n62. The patients were classified according to disease severity as Hurley I 33.7, n34, Hurley II 46.5, n47 and Hurley III 19.8, n20. Patients with early-onset disease and Hurley III HS had a significantly higher number of affected anatomical sites p0.05. The axillary region was the most commonly involved anatomical site n78, followed by the inguinal n57 and gluteal regions n23. Sixty-four patients 74.4 were overweightobese, and 84.5 n71 were current or ex-smokers. Acne vulgaris was the main dermatological comorbidity associated with HS n23. Pilonidal sinus disease was present in 25.5 n25. Patients with Hurley III HS presented with significantly higher rates of pilonidal sinus disease and involvement of the gluteal and perianal regions p0.05. Nineteen patients were diagnosed with metabolic syndrome. Systemic antibiotics were the most frequently prescribed first-line agents. Hidradenitis Suppurativa Clinical Response HiSCR achievement was observed most frequently with biologics, particularly adalimumab. Conclusion: In line with the current literature, HS poses an increased disease burden with its associated comorbidities. The predominance of the male sex and the anatomical involvement patterns seen in our HS patients are compatible with previously reported Turkish series. Pilonidal sinus disease and involvement of the gluteal and perianal regions in HS patients are important signs of severe disease, also highlighted in recent studies. The biologic agents seem to be the best therapeutic option for achieving HiSCR, especially in severe HS forms.

 Objective: To investigate the clinico-epidemiological profile of hidradenitis suppurativa HS patients. Material and Method: In this retrospective cross-sectional single tertiary center study, the HS patients diagnosed andor followed up between 2012-2022 were evaluated regarding demographic features, clinical findings, associated comorbidities, therapies initiated for HS and their outcomes. Results: Of 101 HS patients male:female ratio1.7:1, 23.3 n20 had a history of early-onset disease 18 years. The majority had no family history of HS 82.7, n62. The patients were classified according to disease severity as Hurley I 33.7, n34, Hurley II 46.5, n47 and Hurley III 19.8, n20. Patients with early-onset disease and Hurley III HS had a significantly higher number of affected anatomical sites p0.05. The axillary region was the most commonly involved anatomical site n78, followed by the inguinal n57 and gluteal regions n23. Sixty-four patients 74.4 were overweightobese, and 84.5 n71 were current or ex-smokers. Acne vulgaris was the main dermatological comorbidity associated with HS n23. Pilonidal sinus disease was present in 25.5 n25. Patients with Hurley III HS presented with significantly higher rates of pilonidal sinus disease and involvement of the gluteal and perianal regions p0.05. Nineteen patients were diagnosed with metabolic syndrome. Systemic antibiotics were the most frequently prescribed first-line agents. Hidradenitis Suppurativa Clinical Response HiSCR achievement was observed most frequently with biologics, particularly adalimumab. Conclusion: In line with the current literature, HS poses an increased disease burden with its associated comorbidities. The predominance of the male sex and the anatomical involvement patterns seen in our HS patients are compatible with previously reported Turkish series. Pilonidal sinus disease and involvement of the gluteal and perianal regions in HS patients are important signs of severe disease, also highlighted in recent studies. The biologic agents seem to be the best therapeutic option for achieving HiSCR, especially in severe HS forms.

 Objective: To investigate the clinico-epidemiological profile of hidradenitis suppurativa HS patients. Material and Method: In this retrospective cross-sectional single tertiary center study, the HS patients diagnosed andor followed up between 2012-2022 were evaluated regarding demographic features, clinical findings, associated comorbidities, therapies initiated for HS and their outcomes. Results: Of 101 HS patients male:female ratio1.7:1, 23.3 n20 had a history of early-onset disease 18 years. The majority had no family history of HS 82.7, n62. The patients were classified according to disease severity as Hurley I 33.7, n34, Hurley II 46.5, n47 and Hurley III 19.8, n20. Patients with early-onset disease and Hurley III HS had a significantly higher number of affected anatomical sites p0.05. The axillary region was the most commonly involved anatomical site n78, followed by the inguinal n57 and gluteal regions n23. Sixty-four patients 74.4 were overweightobese, and 84.5 n71 were current or ex-smokers. Acne vulgaris was the main dermatological comorbidity associated with HS n23. Pilonidal sinus disease was present in 25.5 n25. Patients with Hurley III HS presented with significantly higher rates of pilonidal sinus disease and involvement of the gluteal and perianal regions p0.05. Nineteen patients were diagnosed with metabolic syndrome. Systemic antibiotics were the most frequently prescribed first-line agents. Hidradenitis Suppurativa Clinical Response HiSCR achievement was observed most frequently with biologics, particularly adalimumab. Conclusion: In line with the current literature, HS poses an increased disease burden with its associated comorbidities. The predominance of the male sex and the anatomical involvement patterns seen in our HS patients are compatible with previously reported Turkish series. Pilonidal sinus disease and involvement of the gluteal and perianal regions in HS patients are important signs of severe disease, also highlighted in recent studies. The biologic agents seem to be the best therapeutic option for achieving HiSCR, especially in severe HS forms.

 Amaç: Bu çalışmada hidradenitis süpürativa HS hastalarının epidemiyolojik ve klinik özelliklerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Üçüncü basamak bir merkezde yürütülen bu retrospektif kesitsel çalışmada, 2012-2022 tarihlerinde tanı alan veveya takip edilen HS hastaları demografik özellikler, klinik bulgular, eşlik eden komorbiditeler, HS için verilen tedaviler ve tedavi yanıtları açısından değerlendirilmiştir. Bulgular: 101 HS hastasının erkek:kadın oranı1,7:1 23,3ünde n20 erken başlangıç 18 yaş öyküsü mevcuttu. Hastaların büyük çoğunluğunda 82,7; n62 ailede HS öyküsü yoktu. Hastaların hastalık şiddetine göre dağılımları Hurley I 33,7; n34, Hurley II 46,5; n47, Hurley III 19,8; n20 şeklindeydi. Erken başlangıçlı ve Hurley III HS hastalarında anlamlı ölçüde daha fazla anatomik bölge tutulumu saptandı p0,05. En sık tutulum görülen anatomik yerleşim aksiller bölge n78 olup, bunu inguinal n57 ve gluteal bölge n23 takip etmekteydi. Altmışdört hasta 74,4 kiloluobez olup hastaların 84,5inde n71 güncelgeçmiş sigara kullanım öyküsü mevcuttu. HSe en sık eşlik eden dermatolojik hastalık akne vulgaristi n23. Olguların 25,5inde n25 pilonidal sinüs hastalığı mevcuttu. Hurley III HS hastaları önemli ölçüde daha yüksek oranda pilonidal sinüs hastalığı, gluteal ve perianal bölge tutulumu ile başvurdu p0,05. Ondokuz hasta metabolik sendrom tanısı almıştı. Sistemik antibiyotikler en sık reçete edilen birinci basamak ajanlardı. Hidradenitis Süpürativa Klinik Yanıtı HiSCR en yüksek oranda biyolojik ajanlarla özellikle adalimumab gözlendi Sonuç: Mevcut literatür ile uyumlu olarak, HS ilişkili olduğu komorbiditeler ile birlikte hastalık yükünü arttırmaktadır. HS hastalarımızda erkek cinsiyet baskınlığı ve anatomik tutulum paternleri daha önce bildirilen Türk serileri ile uyumludur. Pilonidal sinüs hastalığı, gluteal ve perianal bölge tutulumu HS hastalarında şiddetli hastalık açısından yakın zamanlı çalışmalarda da vurgulanan önemli belirtilerdir. Biyolojik ajanlar, özellikle şiddetli HS formlarında, HiSCR sağlamak için en iyi tedavi seçeneği olarak görünmektedir.

Makale detayları

EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF HIDRADENITIS SUPPURATIVA PATIENTS: 10-YEAR EXPERIENCE FROM A SINGLE TERTIARY CENTER

Yazarlar:

Selda Işık Mermutlu | Zeynep Keskinkaya

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.86 Issue 3, pp.235-244

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293733

pISSN:

1305-6441

Hidradenitis suppurativa

Hurley

chronic inflammation

metabolic syndrome

pilonidal sinusHidradenitis süpürativa

Hurley

kronik inflamasyon

metabolik sendrom

pilonidal sinüs

Sayı

Makale detayları

Yazarlar: Selda Işık Mermutlu | Zeynep Keskinkaya

Yayıncı: Istanbul University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: İstanbul Tıp Fakültesi Dergisi Vol.86 Issue 3, pp.235-244

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293733

pISSN: 1305-6441

Sayı

Yazarlar:

Selda Işık Mermutlu | Zeynep Keskinkaya

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.86 Issue 3, pp.235-244

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293733

pISSN:

1305-6441