Prognostic Significance of Hemoglobin Levels on Survival in Patients with Locally Advanced Rectal Cancer

Neslihan Kurtul; Celalettin Eroğlu

Makale detayları

Prognostic Significance of Hemoglobin Levels on Survival in Patients with Locally Advanced Rectal Cancer

Yazarlar:

Neslihan Kurtul | Celalettin Eroğlu

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 1, pp.65-70

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001343476

pISSN:

1303-6610

Anahtar kelimeler:

Özet:

 Objective: The objective of this study was to investigate whether the hemoglobin Hb level at the time of diagnosis was associated with survival in patients with rectal cancer who were treated with chemoradiotherapy and surgery. Material and Methods: This study was conducted on 98 rectal cancer patients who had undergone neoadjuvantadjuvant radiation therapy. Radiotherapy was delivered to the pelvic lymph nodes and the primary tumor at a dose of 4554 Gy. Patients received 5-fluorouracil 5-FUFAcapecitabine chemotherapy along with radiotherapy. Univariate and multivariate Cox regression analysis were used to evaluate factors determining patient survival. A receiver operating characteristic ROC analysis was performed to ascertain the existence of a threshold for Hb levels in relation to survival. Results: The median overall survival was 61 months 95 CI, 31-90 months. The one-year survival rate was 82, and the five-year survival rate was 50. The optimal Hb threshold was identified as 13.45 gdL, with a sensitivity of 75 and a specificity of 50. The overall survival was 318 months 95 CI; range, 14-48 months in the low Hb group and 8117 months 95 CI; range, 46-116 months in the high group p  0.032. It was determined that the impact of low Hb levels on mortality was more pronounced in patients with T4 tumors and in the neoadjuvant treatment group. In the univariate Cox regression analysis, a statistically significant effect on overall survival was observed for T-stage, N-stage, cancer stage and Hb level. In the multivariate Cox regression analysis, T stage, N stage and Hb level were identified as the significant factors influencing survival, independent of other variables Conclusions: A Hb level below 13.45 gdL was found to be a poor prognostic factor in locally advanced rectal cancer, particularly in cases with T4 tumors or treated with neoadjuvant chemoradiotherapy.

 Objective: The objective of this study was to investigate whether the hemoglobin Hb level at the time of diagnosis was associated with survival in patients with rectal cancer who were treated with chemoradiotherapy and surgery. Material and Methods: This study was conducted on 98 rectal cancer patients who had undergone neoadjuvantadjuvant radiation therapy. Radiotherapy was delivered to the pelvic lymph nodes and the primary tumor at a dose of 4554 Gy. Patients received 5-fluorouracil 5-FUFAcapecitabine chemotherapy along with radiotherapy. Univariate and multivariate Cox regression analysis were used to evaluate factors determining patient survival. A receiver operating characteristic ROC analysis was performed to ascertain the existence of a threshold for Hb levels in relation to survival. Results: The median overall survival was 61 months 95 CI, 31-90 months. The one-year survival rate was 82, and the five-year survival rate was 50. The optimal Hb threshold was identified as 13.45 gdL, with a sensitivity of 75 and a specificity of 50. The overall survival was 318 months 95 CI; range, 14-48 months in the low Hb group and 8117 months 95 CI; range, 46-116 months in the high group p  0.032. It was determined that the impact of low Hb levels on mortality was more pronounced in patients with T4 tumors and in the neoadjuvant treatment group. In the univariate Cox regression analysis, a statistically significant effect on overall survival was observed for T-stage, N-stage, cancer stage and Hb level. In the multivariate Cox regression analysis, T stage, N stage and Hb level were identified as the significant factors influencing survival, independent of other variables Conclusions: A Hb level below 13.45 gdL was found to be a poor prognostic factor in locally advanced rectal cancer, particularly in cases with T4 tumors or treated with neoadjuvant chemoradiotherapy.

 Objective: The objective of this study was to investigate whether the hemoglobin Hb level at the time of diagnosis was associated with survival in patients with rectal cancer who were treated with chemoradiotherapy and surgery. Material and Methods: This study was conducted on 98 rectal cancer patients who had undergone neoadjuvantadjuvant radiation therapy. Radiotherapy was delivered to the pelvic lymph nodes and the primary tumor at a dose of 4554 Gy. Patients received 5-fluorouracil 5-FUFAcapecitabine chemotherapy along with radiotherapy. Univariate and multivariate Cox regression analysis were used to evaluate factors determining patient survival. A receiver operating characteristic ROC analysis was performed to ascertain the existence of a threshold for Hb levels in relation to survival. Results: The median overall survival was 61 months 95 CI, 31-90 months. The one-year survival rate was 82, and the five-year survival rate was 50. The optimal Hb threshold was identified as 13.45 gdL, with a sensitivity of 75 and a specificity of 50. The overall survival was 318 months 95 CI; range, 14-48 months in the low Hb group and 8117 months 95 CI; range, 46-116 months in the high group p  0.032. It was determined that the impact of low Hb levels on mortality was more pronounced in patients with T4 tumors and in the neoadjuvant treatment group. In the univariate Cox regression analysis, a statistically significant effect on overall survival was observed for T-stage, N-stage, cancer stage and Hb level. In the multivariate Cox regression analysis, T stage, N stage and Hb level were identified as the significant factors influencing survival, independent of other variables Conclusions: A Hb level below 13.45 gdL was found to be a poor prognostic factor in locally advanced rectal cancer, particularly in cases with T4 tumors or treated with neoadjuvant chemoradiotherapy.

 Amaç: Bu çalışmada kemoradyoterapi ve cerrahi ile birlikte tedavi edilen rektum kanserinde tanı anındaki hemoglobin Hb değerinin sağkalım üzerine etkisi olup olmadığı araştırıldı. Gereç ve Yöntemler: Rektum kanseri nedeniyle neoadjuvanadjuvan radyoterapi RT alan 98 hasta çalışmaya dahil edildi. RT neoadjuvan ya da adjuvan pelvik lenf nodları ve primer tümör alanına 45-54 Gy uygulandı. RT ile eşzamanlı 5-FUFA veya kapesitabin kullanıldı. Sağkalımı belirleyen faktörleri değerlendirmek üzere tek değişkenli ve çok değişkenli Cox regresyon analizi yapıldı. Sağkalım açısından Hb düzeyinde sınır değer olup olmadığını bulmak için ROC analizi yapıldı. Bulgular: Medyan genel sağkalım 61 ay 95 CI 31-90, 1 yıllık sağkalım 82, 5 yıllık sağkalım 50 olarak bulundu. Hb sınır değeri 75 duyarlılık ve 50 özgüllükle 13,45 gdL olarak belirlendi. Hb düşük grupta genel sağkalım 318 95 CI:14-48 ay yüksek grupta 8117 95 CI:46-116 aydı p0.032. T4 tümörlerde ve neoadjuvan grupta Hb düşüklüğünün mortalite üzerine etkisi daha belirgindi. Tek değişkenli Cox regresyon analizinde T evre, N evre ve Hb düzeyinin 13,75 gdlnin altında veya üzerinde olması sağkalım üzerine etkili faktörler olarak bulundu. Çok değişkenli Cox regresyon analizinde ise T evre, N evre ve Hb düzeyi sağkalım üzerinde etkili faktörlerdi Sonuç: Hb düzeyinin 13.45 gdlnin altında olması lokal ileri rektum kanserinde, özellikle T4 tümörlü veya neoadjuvan kemoradyoterapi gören hastalarda kötü bir prognostik faktör olduğu görüldü.

Makale detayları

Prognostic Significance of Hemoglobin Levels on Survival in Patients with Locally Advanced Rectal Cancer

Yazarlar:

Neslihan Kurtul | Celalettin Eroğlu

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 1, pp.65-70

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001343476

pISSN:

1303-6610

Hemoglobin

Radiotherapy

Rectal Cancer

SurvivalHemoglobin

Radyoterapi

Rektm Kanseri

Sağkalım

Sayı

Makale detayları

Yazarlar: Neslihan Kurtul | Celalettin Eroğlu

Yayıncı: Kahramanmaras Sutcu Imam University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 1, pp.65-70

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001343476

pISSN: 1303-6610

Sayı

Yazarlar:

Neslihan Kurtul | Celalettin Eroğlu

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 1, pp.65-70

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001343476

pISSN:

1303-6610