Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization

Prabhu Halakatti; Mallappa Shalavadi

Makale detayları

Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization

Yazarlar:

Prabhu Halakatti | Mallappa Shalavadi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1423-1434

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347573

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The aim of present work is to formulate and characterize the Vildagliptin VLD loaded polymeric nanoparticles for the treatment of type II diabetes mellitus. Polymeric nanoparticles were prepared by ionotropic gelation method with sodium tripolyphosphate STPP as a cross linkers. The obtained sample of VLD was evaluated by UV and FT-IR studies. Prepared polymeric nanoparticles were characterized in term of drug-polymer intraction, particle size and polydispersity index PDI, zeta potential,  drug content DC,  drug entrapment efficiency DEE and scanning electron microscopy SEM. In vitro and in vivo drug release studies were also performed. FT-IR study showed that drug and polymers are compatible with each other and cross-linking was observed between chitosan and STPP. Particle size was range from 238.2 nm to 708.8nm for all the formulations. Zeta potential was range from-8.49mV to 11.1mV. DC range from68.12 to 84.37, and  DEE was range from 78.76 to 93.91. SEM images showed that the prepared formulations were smooth and spherical. In vitro drug release evaluation in phosphate buffer pH 7.4 showed sustained release pattern, i.e. 55.17 to 62.89 within 12hours. The data were fitted to Korsmeyer-Peppas model which showed fickian diffusion as a predominant release mechanism. In vivo drug release evalutionshowed significant decrease in the blood glucose level. Thus, conclude that prepared polymeric nanoparticles by ionotropic gelation method have a sustain release pattern and incresesstabilty of drug.

 The aim of present work is to formulate and characterize the Vildagliptin VLD loaded polymeric nanoparticles for the treatment of type II diabetes mellitus. Polymeric nanoparticles were prepared by ionotropic gelation method with sodium tripolyphosphate STPP as a cross linkers. The obtained sample of VLD was evaluated by UV and FT-IR studies. Prepared polymeric nanoparticles were characterized in term of drug-polymer intraction, particle size and polydispersity index PDI, zeta potential,  drug content DC,  drug entrapment efficiency DEE and scanning electron microscopy SEM. In vitro and in vivo drug release studies were also performed. FT-IR study showed that drug and polymers are compatible with each other and cross-linking was observed between chitosan and STPP. Particle size was range from 238.2 nm to 708.8nm for all the formulations. Zeta potential was range from-8.49mV to 11.1mV. DC range from68.12 to 84.37, and  DEE was range from 78.76 to 93.91. SEM images showed that the prepared formulations were smooth and spherical. In vitro drug release evaluation in phosphate buffer pH 7.4 showed sustained release pattern, i.e. 55.17 to 62.89 within 12hours. The data were fitted to Korsmeyer-Peppas model which showed fickian diffusion as a predominant release mechanism. In vivo drug release evalutionshowed significant decrease in the blood glucose level. Thus, conclude that prepared polymeric nanoparticles by ionotropic gelation method have a sustain release pattern and incresesstabilty of drug.

 The aim of present work is to formulate and characterize the Vildagliptin VLD loaded polymeric nanoparticles for the treatment of type II diabetes mellitus. Polymeric nanoparticles were prepared by ionotropic gelation method with sodium tripolyphosphate STPP as a cross linkers. The obtained sample of VLD was evaluated by UV and FT-IR studies. Prepared polymeric nanoparticles were characterized in term of drug-polymer intraction, particle size and polydispersity index PDI, zeta potential,  drug content DC,  drug entrapment efficiency DEE and scanning electron microscopy SEM. In vitro and in vivo drug release studies were also performed. FT-IR study showed that drug and polymers are compatible with each other and cross-linking was observed between chitosan and STPP. Particle size was range from 238.2 nm to 708.8nm for all the formulations. Zeta potential was range from-8.49mV to 11.1mV. DC range from68.12 to 84.37, and  DEE was range from 78.76 to 93.91. SEM images showed that the prepared formulations were smooth and spherical. In vitro drug release evaluation in phosphate buffer pH 7.4 showed sustained release pattern, i.e. 55.17 to 62.89 within 12hours. The data were fitted to Korsmeyer-Peppas model which showed fickian diffusion as a predominant release mechanism. In vivo drug release evalutionshowed significant decrease in the blood glucose level. Thus, conclude that prepared polymeric nanoparticles by ionotropic gelation method have a sustain release pattern and incresesstabilty of drug.

 The aim of present work is to formulate and characterize the Vildagliptin VLD loaded polymeric nanoparticles for the treatment of type II diabetes mellitus. Polymeric nanoparticles were prepared by ionotropic gelation method with sodium tripolyphosphate STPP as a cross linkers. The obtained sample of VLD was evaluated by UV and FT-IR studies. Prepared polymeric nanoparticles were characterized in term of drug-polymer intraction, particle size and polydispersity index PDI, zeta potential,  drug content DC,  drug entrapment efficiency DEE and scanning electron microscopy SEM. In vitro and in vivo drug release studies were also performed. FT-IR study showed that drug and polymers are compatible with each other and cross-linking was observed between chitosan and STPP. Particle size was range from 238.2 nm to 708.8nm for all the formulations. Zeta potential was range from-8.49mV to 11.1mV. DC range from68.12 to 84.37, and  DEE was range from 78.76 to 93.91. SEM images showed that the prepared formulations were smooth and spherical. In vitro drug release evaluation in phosphate buffer pH 7.4 showed sustained release pattern, i.e. 55.17 to 62.89 within 12hours. The data were fitted to Korsmeyer-Peppas model which showed fickian diffusion as a predominant release mechanism. In vivo drug release evalutionshowed significant decrease in the blood glucose level. Thus, conclude that prepared polymeric nanoparticles by ionotropic gelation method have a sustain release pattern and incresesstabilty of drug.

Makale detayları

Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization

Yazarlar:

Prabhu Halakatti | Mallappa Shalavadi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1423-1434

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347573

pISSN:

2630-6344

Vildagliptin

Chitosan

STPP

Ionotropic gelation method

Polymeric nanoparticle

anti diabetic activity

Sayı

Makale detayları

Vildagliptin loaded polymeric nanoparticles using cross-linked polymer by ionotropic gelation method: development and characterization

Yazarlar: Prabhu Halakatti | Mallappa Shalavadi

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.28 Issue 5, pp.1423-1434

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347573

pISSN: 2630-6344

Vildagliptin

Chitosan

STPP

Ionotropic gelation method

Polymeric nanoparticle

anti diabetic activity

Sayı

Yazarlar:

Prabhu Halakatti | Mallappa Shalavadi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1423-1434

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347573

pISSN:

2630-6344