Structural chromosomal abnormalities in couples with recurrent abortion in Egypt

Nagwa E.a. GABOON; Ahmed Ramy MOHAMED; Solaf M. ELSAYED; Osama K. ZAKI; Mohamed A. ELSAYED

Makale detayları

Structural chromosomal abnormalities in couples with recurrent abortion in Egypt

Yazarlar:

Nagwa E.a. GABOON | Ahmed Ramy MOHAMED | Solaf M. ELSAYED | Osama K. ZAKI | Mohamed A. ELSAYED

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 1, pp.208-213

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752915

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To evaluate the incidence of chromosomal abnormalities in couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis.   Materials and methods: The present study examined 125 couples who had experienced recurrent abortion. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Women in the study group underwent biochemical testing and pelvic ultrasound examinations, and men underwent a semen analysis.   Results: Among the 125 couples tested, 8 couples (6.4%) displayed a balanced translocation, among which 7 (5.6%) showed a reciprocal translocation and 1 (0.8%) showed a Robertsonian translocation. All carriers of these translocations were aged  2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.

 

To evaluate the incidence of chromosomal abnormalities in couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis.   Materials and methods: The present study examined 125 couples who had experienced recurrent abortion. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Women in the study group underwent biochemical testing and pelvic ultrasound examinations, and men underwent a semen analysis.   Results: Among the 125 couples tested, 8 couples (6.4%) displayed a balanced translocation, among which 7 (5.6%) showed a reciprocal translocation and 1 (0.8%) showed a Robertsonian translocation. All carriers of these translocations were aged  2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.

Makale detayları

Structural chromosomal abnormalities in couples with recurrent abortion in Egypt

Yazarlar:

Nagwa E.a. GABOON | Ahmed Ramy MOHAMED | Solaf M. ELSAYED | Osama K. ZAKI | Mohamed A. ELSAYED

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 1, pp.208-213

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752915

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Recurrent abortion

chromosomal abnormality

balanced carrier

Sayı

Makale detayları

Structural chromosomal abnormalities in couples with recurrent abortion in Egypt

Yazarlar: Nagwa E.a. GABOON | Ahmed Ramy MOHAMED | Solaf M. ELSAYED | Osama K. ZAKI | Mohamed A. ELSAYED

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 1, pp.208-213

Belge Tipi: Makale

Yayın Tarihi: 3/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000752915

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Recurrent abortion

chromosomal abnormality

balanced carrier

Sayı

Yazarlar:

Nagwa E.a. GABOON | Ahmed Ramy MOHAMED | Solaf M. ELSAYED | Osama K. ZAKI | Mohamed A. ELSAYED

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 1, pp.208-213

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752915

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144