The role of perivascular adipose tissue on human saphenous vein vascular tone

Gülsev ÖZEN; B. Sönmez UYDEŞ DOĞAN; Önder TESKİN; Xavier NOREL; Gökçe TOPAL

Makale detayları

The role of perivascular adipose tissue on human saphenous vein vascular tone

Yazarlar:

Gülsev ÖZEN | B. Sönmez UYDEŞ DOĞAN | Önder TESKİN | Xavier NOREL | Gökçe TOPAL

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Journal of Faculty of Pharmacy of Istanbul University 2016 Vol.46 Issue 1, pp.1-13

Belge Tipi:

Makale

Yayın Tarihi:

8/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000513122

Sıklık:

Aylık

eISSN:

2587-2087

Özet:

 


Perivascular adipose tissue (PVAT) is situated outside of almost every blood vessel. Recent studies showed that PVAT provides mechanical support for blood vessels and secretes vasoactive adipokines that could regulate vascular tone. However, most of the studies evaluating PVAT effects on vascular tone have been performed with vessels derived from animals. Therefore, we aimed to investigate the role of PVAT surrounding human coronary bypass graft vessels such as saphenous vein (SV). Human SV preparations were set up in an organ bath in the presence or absence of their PVAT. The presence of PVAT significantly attenuated the contractile response to prostaglandin F2α (PGF2α). However, potassium chloride (KCI)-induced concentration-response curve wasn’t modified in PVAT-intact SV preparations. On the other hand, endothelium-dependent relaxation induced by acetylcholine (ACh) or endothelium-independent relaxation induced by sodium nitroprusside (SNP) were similar between SV with PVAT versus SV without PVAT preparations. Sensitivity of the SV to contractile agonists (KCI, PGF2α) or relaxant agonists (SNP, ACh) were not modified in the presence of PVAT. These results suggest that PVAT could decrease PGF2α-induced contractile tone via endothelium-independent mechanisms in SV. Retaining PVAT in SV preparations during bypass graft surgery could prevent graft vasospasm possibly via PVAT derived relaxant factor(s).

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Makale detayları

The role of perivascular adipose tissue on human saphenous vein vascular tone

Yazarlar: Gülsev ÖZEN | B. Sönmez UYDEŞ DOĞAN | Önder TESKİN | Xavier NOREL | Gökçe TOPAL

Yayıncı: Istanbul University

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: Journal of Faculty of Pharmacy of Istanbul University 2016 Vol.46 Issue 1, pp.1-13

Belge Tipi: Makale

Yayın Tarihi: 8/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000513122

Sıklık: Aylık

eISSN: 2587-2087

Sayı

Yazarlar:

Gülsev ÖZEN | B. Sönmez UYDEŞ DOĞAN | Önder TESKİN | Xavier NOREL | Gökçe TOPAL

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Journal of Faculty of Pharmacy of Istanbul University 2016 Vol.46 Issue 1, pp.1-13

Belge Tipi:

Makale

Yayın Tarihi:

8/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000513122

Sıklık:

Aylık

eISSN:

2587-2087