Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2- carboxamide Derivatives

Mutlu Dilsiz AYTEMİR; Dilek Demir EROL

Makale detayları

Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2- carboxamide Derivatives

Yazarlar:

Mutlu Dilsiz AYTEMİR | Dilek Demir EROL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2003 Vol.27 Issue 6, pp.757-764

Belge Tipi:

Makale

Yayın Tarihi:

5/2003

Belge Dili:

Türkçe

Document ID (Org No.):

2000729472

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The synthesis of a range of 3-hydroxy-4-oxo-4H-pyran-2-  carboxamide with antimicrobial activity is described.  Amide  derivatives of pyranone were synthesised using TBTU  [2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium  tetrafluoroborate] as a coupling agent and NMM (N-methylmorpholine) as  a base.  Antimicrobial activities were determined as MIC values using  the microdilution broth method against Staphylococcus aureus,  Entrococcus faecalis, Escherichia coli and Pseudomonas aeruginosa for  bacteria and Candida albicans, C. krusei and C. parapsilosis for  fungi. 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-[N-(4'-methylcoumarin-7-yl)  carboxamide] (8c) exhibited higher antibacterial activity against S.  aureus, E. faecalis and E. coli than the other compounds.  In  addition, 8c was more active against C. krusei than the other  synthesised compounds.

 

The synthesis of a range of 3-hydroxy-4-oxo-4H-pyran-2-  carboxamide with antimicrobial activity is described.  Amide  derivatives of pyranone were synthesised using TBTU  [2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium  tetrafluoroborate] as a coupling agent and NMM (N-methylmorpholine) as  a base.  Antimicrobial activities were determined as MIC values using  the microdilution broth method against Staphylococcus aureus,  Entrococcus faecalis, Escherichia coli and Pseudomonas aeruginosa for  bacteria and Candida albicans, C. krusei and C. parapsilosis for  fungi. 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-[N-(4'-methylcoumarin-7-yl)  carboxamide] (8c) exhibited higher antibacterial activity against S.  aureus, E. faecalis and E. coli than the other compounds.  In  addition, 8c was more active against C. krusei than the other  synthesised compounds.

Makale detayları

Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2- carboxamide Derivatives

Yazarlar: Mutlu Dilsiz AYTEMİR | Dilek Demir EROL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2003 Vol.27 Issue 6, pp.757-764

Belge Tipi: Makale

Yayın Tarihi: 5/2003

Belge Dili: Türkçe

Document ID (Org No.): 2000729472

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Mutlu Dilsiz AYTEMİR | Dilek Demir EROL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2003 Vol.27 Issue 6, pp.757-764

Belge Tipi:

Makale

Yayın Tarihi:

5/2003

Belge Dili:

Türkçe

Document ID (Org No.):

2000729472

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527