Synthesis and anti-Helicobacter pylori activity of (4-nitro-1-imidazolylmethyl)-1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles

Asal Fallah TAFTI; Tahmineh AKBARZADEH; Parastoo SANIEE

doi:https://doi.org/10.3906/sag-1208-4

Makale detayları

Synthesis and anti-Helicobacter pylori activity of (4-nitro-1-imidazolylmethyl)-1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles

Yazarlar:

Asal Fallah TAFTI | Tahmineh AKBARZADEH | Parastoo SANIEE

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2011 Vol.35 Issue 2, pp.307-316

Belge Tipi:

Makale

Yayın Tarihi:

1/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000727883

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/sag-1208-4

Özet:

 

A series of [(4-nitro-1H-imidazol-1-yl)methyl]-1,2,4-  triazoles and 1,3,4-thiadiazoles were prepared and evaluated for their  activity against sensitive and resistant H. pylori strains.  Study of  the structure-activity relationship of these series of compounds  indicated that the type of nitroimidazole moiety and the pendent group  on the heteroaryl analog dramatically impact the anti-H. pylori  activity.  In triazole series, compound 5d, containing a 4-methyl  phenyl group on the triazole ring, was the most potent compound tested  against both metronidazole-sensitive and -resistant strains at a  concentration of 8 m g.

 

A series of [(4-nitro-1H-imidazol-1-yl)methyl]-1,2,4-  triazoles and 1,3,4-thiadiazoles were prepared and evaluated for their  activity against sensitive and resistant H. pylori strains.  Study of  the structure-activity relationship of these series of compounds  indicated that the type of nitroimidazole moiety and the pendent group  on the heteroaryl analog dramatically impact the anti-H. pylori  activity.  In triazole series, compound 5d, containing a 4-methyl  phenyl group on the triazole ring, was the most potent compound tested  against both metronidazole-sensitive and -resistant strains at a  concentration of 8 m g.

Makale detayları

Synthesis and anti-Helicobacter pylori activity of (4-nitro-1-imidazolylmethyl)-1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles

Yazarlar: Asal Fallah TAFTI | Tahmineh AKBARZADEH | Parastoo SANIEE

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2011 Vol.35 Issue 2, pp.307-316

Belge Tipi: Makale

Yayın Tarihi: 1/2011

Belge Dili: İngilizce

Document ID (Org No.): 2000727883

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/sag-1208-4

Sayı

Yazarlar:

Asal Fallah TAFTI | Tahmineh AKBARZADEH | Parastoo SANIEE

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2011 Vol.35 Issue 2, pp.307-316

Belge Tipi:

Makale

Yayın Tarihi:

1/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000727883

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/sag-1208-4