İSKEMİ/REPERFÜZYON HASARI OLUŞTURULAN RATLARDA MELATONİNİN BÖBREK FONKSİYONLARI ÜZERİNE ETKİSİ

Mustafa NİSARİ

Makale detayları

İSKEMİ/REPERFÜZYON HASARI OLUŞTURULAN RATLARDA MELATONİNİN BÖBREK FONKSİYONLARI ÜZERİNE ETKİSİ

Yazarlar:

Mustafa NİSARİ

Yayıncı:

Erciyes University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Health Sciences 2018 Vol.27 Issue 3, pp.217-220

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000613668

Sıklık:

Üç Yıllık

pISSN:

1018-3655

Özet:

 


Objective: Oxygen free radicals are considered to be
imp orta nt comp onents involved in the
pathophysiological tissue alterations observed during
ischemia/reperfusion. In this study, we investigated the
protective effect of melatonin, potent antioxidant, on
kidney functions and damage during the experimental
renal ischemia reperfusion injury in rats.
Materials and Methods: In this study we used 28
female wistar albino rats 200-250 g. The animals were
randomly divided into 4 groups (n=7). Control group
(C): They were fed with only standard rat diet and tap
water. I/R group: Rats were subjected to 45 min of
renal pedicle occlusion followed by 24 hours
reperfusion. Melatonin group (Mel): Melatonin (25 mg/
kg i.p) was administered. I/R+Mel group: Melatonin (25
mg/kg i.p) was administered 30 min prior to ischemia
and immediately before the reperfusion period. Rats
were subjected to 45 min of renal pedicle occlusion
followed by 24 hours reperfusion. Urea, uric acid and
levels of creatinine, aspartate aminotransferase (AST),
and alanine aminotransferase (ALT) in serum were
evaluated.
Results: Urea, uric acid creatinine, AST, and ALT levels
in the I-R group were higher than those in C, Mel, and I/
R+Mel groups were found to be statistically significant
(p< 0.001). In this case, renal I/R injury showed that the
damage to the kidneys.
Conclusions: These results show that treatment with
Mel may prevent the kidney tissues damages due to
ischaemia. 

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Makale detayları

İSKEMİ/REPERFÜZYON HASARI OLUŞTURULAN RATLARDA MELATONİNİN BÖBREK FONKSİYONLARI ÜZERİNE ETKİSİ

Yazarlar: Mustafa NİSARİ

Yayıncı: Erciyes University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Health Sciences 2018 Vol.27 Issue 3, pp.217-220

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000613668

Sıklık: Üç Yıllık

pISSN: 1018-3655

Sayı

Yazarlar:

Mustafa NİSARİ

Yayıncı:

Erciyes University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Health Sciences 2018 Vol.27 Issue 3, pp.217-220

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000613668

Sıklık:

Üç Yıllık

pISSN:

1018-3655