The expression of EGFR, cerbB2, p16, and p53 and their relationship with conventional parameters in squamous cell carcinoma of the larynx

Hülya ŞİMŞEK; Ünsal HAN; Binnur ÖNAL; Gülçin ŞİMŞEK

doi:https://doi.org/10.3906/sag-1305-9

Makale detayları

The expression of EGFR, cerbB2, p16, and p53 and their relationship with conventional parameters in squamous cell carcinoma of the larynx

Yazarlar:

Hülya ŞİMŞEK | Ünsal HAN | Binnur ÖNAL | Gülçin ŞİMŞEK

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 3, pp.411-416

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000753235

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1305-9

Anahtar kelimeler:

Özet:

 

To investigate the expression of epidermal growth factor receptor¬-HER1 (EGFR), cerbB2 (HER2), p16, and p53, as well as the relationship of the expression of these genes with conventional parameters in squamous cell carcinoma (SCC) of the larynx.  Materials and methods: Samples from 92 cases of diagnosed laryngeal SCC between 2001 and 2011 from the Pathology Department of Ministry of Health Ankara Dışkapı Yıldırım Beyazıt Teaching & Research Hospital were studied by immunohistochemistry using EGFR, cerbB2, p16, and p53 antibodies.  Results: An increase in the TNM stage and pathological tumor size status correlated with an increase in EGFR and cerbB2 expression. In the cases with lymphovascular invasion, the expression was detected at a higher ratio. Cases in which high levels of p16 and p53 expression were observed did not show any lymphovascular invasions.  Conclusion: Expressions of p53 and p16 were considered to be most effective in early carcinogenesis stages of laryngeal SCC. In comparison with p53 and p16 expression levels, EGFR and cerbB2 expression levels were observed to be associated with poor prognostic parameters and were higher at later stages of laryngeal carcinogenesis development.

 

To investigate the expression of epidermal growth factor receptor¬-HER1 (EGFR), cerbB2 (HER2), p16, and p53, as well as the relationship of the expression of these genes with conventional parameters in squamous cell carcinoma (SCC) of the larynx.  Materials and methods: Samples from 92 cases of diagnosed laryngeal SCC between 2001 and 2011 from the Pathology Department of Ministry of Health Ankara Dışkapı Yıldırım Beyazıt Teaching & Research Hospital were studied by immunohistochemistry using EGFR, cerbB2, p16, and p53 antibodies.  Results: An increase in the TNM stage and pathological tumor size status correlated with an increase in EGFR and cerbB2 expression. In the cases with lymphovascular invasion, the expression was detected at a higher ratio. Cases in which high levels of p16 and p53 expression were observed did not show any lymphovascular invasions.  Conclusion: Expressions of p53 and p16 were considered to be most effective in early carcinogenesis stages of laryngeal SCC. In comparison with p53 and p16 expression levels, EGFR and cerbB2 expression levels were observed to be associated with poor prognostic parameters and were higher at later stages of laryngeal carcinogenesis development.

Makale detayları

The expression of EGFR, cerbB2, p16, and p53 and their relationship with conventional parameters in squamous cell carcinoma of the larynx

Yazarlar:

Hülya ŞİMŞEK | Ünsal HAN | Binnur ÖNAL | Gülçin ŞİMŞEK

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 3, pp.411-416

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000753235

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1305-9

Key words: Laryngeal carcinoma

carcinogenesis

prognosis

EGFR

cerbB2

p16

p53

immunohistochemistry

Sayı

Makale detayları

Yazarlar: Hülya ŞİMŞEK | Ünsal HAN | Binnur ÖNAL | Gülçin ŞİMŞEK

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2014 Vol.44 Issue 3, pp.411-416

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000753235

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1305-9

Sayı

Yazarlar:

Hülya ŞİMŞEK | Ünsal HAN | Binnur ÖNAL | Gülçin ŞİMŞEK

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 3, pp.411-416

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000753235

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1305-9