Periventricular Leukomalacia: Comparison of Parenchymal Signal and Volume Changes on Brain MRI in Paediatric Cases with Healthy Peers

Hanife Gülden Düzkalır; İrem Sarı; Fulden Cantaş Türkiş; Safiye Güneş Sağer; Emine Çalışkan; Tamer Baysal

Makale detayları

Periventricular Leukomalacia: Comparison of Parenchymal Signal and Volume Changes on Brain MRI in Paediatric Cases with Healthy Peers

Yazarlar:

Hanife Gülden Düzkalır | İrem Sarı | Fulden Cantaş Türkiş | Safiye Güneş Sağer | Emine Çalışkan | Tamer Baysal

Yayıncı:

Selcuk University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.34 Issue 4, pp.547-553

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325825

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Backgroundaims: Previous MRI studies have shown white matter WM and gray matter GM of cerebrum and cerebellum, corpus callosum CC abnormalities in periventricular leukomalacia PVL. But, the WM FLAIR signal ratio in MRI may provide quantitative data in the diagnosis and follow-up, as a new radiologic method. Thalamic involvement may be a biomarker for neuronal damage and disease severity. We aimed to re-investigate both WM and GM volume changes of cerebrum and cerebellum, CC surface area in PVL, and to evaluate the diagnostic accuracy of the thalamus L sign and FLAIR signal ratio. Methods: MRI scans of 30 pediatric patients with PVL and 42 healthy controls were analyzed to examine WM and GM volume changes, FLAIR signal ratio, CC surface area, and thalamus L sign. Volumetric analyses were done with the Volbrain program. Results: Decreased subcortical GM volumes were found in PVL p0.001. There was a significant positive correlation between FLAIR signal ratio, various GM and cerebellum volumes. In patients with thalamus L sign, decreased GM volume and increased abnormal signaled WM volume were observed. The most important variable in the diagnosis of PVL was abnormally signaled WM volume p0.001. Conclusions: Our results emphasise the role of MRI in the detection of PVL, the evaluation of GM changes and brain damage, and the importance of thalamus L sign and FLAIR signal ratio in the evaluation of the severity of the disease. Comprehensive studies in this direction may contribute to the development of targeted treatment strategies aimed at reducing cognitive and motor impairments in PVL.

 Backgroundaims: Previous MRI studies have shown white matter WM and gray matter GM of cerebrum and cerebellum, corpus callosum CC abnormalities in periventricular leukomalacia PVL. But, the WM FLAIR signal ratio in MRI may provide quantitative data in the diagnosis and follow-up, as a new radiologic method. Thalamic involvement may be a biomarker for neuronal damage and disease severity. We aimed to re-investigate both WM and GM volume changes of cerebrum and cerebellum, CC surface area in PVL, and to evaluate the diagnostic accuracy of the thalamus L sign and FLAIR signal ratio. Methods: MRI scans of 30 pediatric patients with PVL and 42 healthy controls were analyzed to examine WM and GM volume changes, FLAIR signal ratio, CC surface area, and thalamus L sign. Volumetric analyses were done with the Volbrain program. Results: Decreased subcortical GM volumes were found in PVL p0.001. There was a significant positive correlation between FLAIR signal ratio, various GM and cerebellum volumes. In patients with thalamus L sign, decreased GM volume and increased abnormal signaled WM volume were observed. The most important variable in the diagnosis of PVL was abnormally signaled WM volume p0.001. Conclusions: Our results emphasise the role of MRI in the detection of PVL, the evaluation of GM changes and brain damage, and the importance of thalamus L sign and FLAIR signal ratio in the evaluation of the severity of the disease. Comprehensive studies in this direction may contribute to the development of targeted treatment strategies aimed at reducing cognitive and motor impairments in PVL.

 Backgroundaims: Previous MRI studies have shown white matter WM and gray matter GM of cerebrum and cerebellum, corpus callosum CC abnormalities in periventricular leukomalacia PVL. But, the WM FLAIR signal ratio in MRI may provide quantitative data in the diagnosis and follow-up, as a new radiologic method. Thalamic involvement may be a biomarker for neuronal damage and disease severity. We aimed to re-investigate both WM and GM volume changes of cerebrum and cerebellum, CC surface area in PVL, and to evaluate the diagnostic accuracy of the thalamus L sign and FLAIR signal ratio. Methods: MRI scans of 30 pediatric patients with PVL and 42 healthy controls were analyzed to examine WM and GM volume changes, FLAIR signal ratio, CC surface area, and thalamus L sign. Volumetric analyses were done with the Volbrain program. Results: Decreased subcortical GM volumes were found in PVL p0.001. There was a significant positive correlation between FLAIR signal ratio, various GM and cerebellum volumes. In patients with thalamus L sign, decreased GM volume and increased abnormal signaled WM volume were observed. The most important variable in the diagnosis of PVL was abnormally signaled WM volume p0.001. Conclusions: Our results emphasise the role of MRI in the detection of PVL, the evaluation of GM changes and brain damage, and the importance of thalamus L sign and FLAIR signal ratio in the evaluation of the severity of the disease. Comprehensive studies in this direction may contribute to the development of targeted treatment strategies aimed at reducing cognitive and motor impairments in PVL.

 Amaç: Önceki MRG çalışmaları periventriküler lökomalazide PVL serebrum ve serebellumun beyaz cevher BC ve gri cevher GC, korpus kallozum KK anormalliklerini göstermiştir. Ancak MRGde BC FLAIR sinyal oranı yeni bir radyolojik yöntem olarak tanı ve takipte kantitatif veri sağlayabilir. Talamik tutulum nöronal hasar ve hastalık şiddeti için bir biyobelirteç olabilir. Bu çalışmada PVLde serebrum ve serebellumun BC ve GC hacim değişikliklerini, KK yüzey alanını detaylı araştırmayı, talamus L işareti ve FLAIR sinyal oranının tanısal doğruluğunu değerlendirmeyi amaçladık. Gereç ve Yöntemler: PVLli 30 pediatrik hastanın ve 42 sağlıklı kontrolün MRG taramaları, BC ve GC hacim değişikliklerini, FLAIR sinyal oranını, KK yüzey alanını ve talamus L işaretini incelemek için analiz edildi. Volümetrik analizler Volbrain programı ile yapıldı. Bulgular: PVLde subkortikal BC hacimlerinde azalma saptadık p0.001. FLAIR sinyal oranı ile çeşitli GC ve serebellum hacimleri arasında anlamlı pozitif korelasyon bulduk. Talamus L işareti bulgusu olan hastalarda azalmış GC hacmi ve artmış anormal sinyalli BC hacmi gözledik. PVL tanısında en önemli değişken olarak anormal sinyalli BC hacmini bulduk p0.001. Sonuç: Sonuçlarımız PVLnin saptanmasında, GC değişikliklerinin ve beyin hasarının değerlendirilmesinde MRGnin rolünü ve hastalığın ciddiyetinin değerlendirilmesinde talamus L işaretinin ve FLAIR sinyal oranının önemini vurgulamaktadır. Bu yönde kapsamlı çalışmalar PVLde bilişsel ve motor bozuklukları azaltmayı amaçlayan hedefe yönelik tedavi stratejilerinin geliştirilmesine katkıda bulunabilir.

Makale detayları

Periventricular Leukomalacia: Comparison of Parenchymal Signal and Volume Changes on Brain MRI in Paediatric Cases with Healthy Peers

Yazarlar:

Hanife Gülden Düzkalır | İrem Sarı | Fulden Cantaş Türkiş | Safiye Güneş Sağer | Emine Çalışkan | Tamer Baysal

Yayıncı:

Selcuk University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.34 Issue 4, pp.547-553

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325825

pISSN:

2602-3741

periventricular leukomalacia

brain volume

FLAIR signal ratio

thalamus L sign

gray matter

corpus callosumperiventriküler lökomalazi

beyin hacmi

FLAIR sinyal oranı

talamus L işareti

gri madde

korpus kallozum

Sayı

Makale detayları

Yazarlar: Hanife Gülden Düzkalır | İrem Sarı | Fulden Cantaş Türkiş | Safiye Güneş Sağer | Emine Çalışkan | Tamer Baysal

Yayıncı: Selcuk University

Ana Başlıklar: Radyoloji ve Organ Görüntüleme | Klinik Tıp Bilimleri (Diğer)

Dergi: Genel Tıp Dergisi Vol.34 Issue 4, pp.547-553

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001325825

pISSN: 2602-3741

Sayı

Yazarlar:

Hanife Gülden Düzkalır | İrem Sarı | Fulden Cantaş Türkiş | Safiye Güneş Sağer | Emine Çalışkan | Tamer Baysal

Yayıncı:

Selcuk University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.34 Issue 4, pp.547-553

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325825

pISSN:

2602-3741