Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model

Hasan Metineren; Turan Cihan Dülgeroğlu

doi:https://doi.org/10.18621/eurj.373385

Makale detayları

Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model

Yazarlar:

Hasan Metineren | Turan Cihan Dülgeroğlu

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2019 Vol.5 Issue 2, pp.299-305

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000662830

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.373385

Özet:

 


Objectives:
Different materials are currently being used experimentally to accelerate
cartilage healing and to obtain hyaline cartilage. We aimed to investigate the
effect of platelet-rich fibrin on joint cartilage healing. 


Methods:
Twenty rats were used in this study. platelet-rich fibrin was obtained from
4 rats, and the remaining 16 rats were randomly divided into two groups (4 and
8 weeks). Both knee joints were prepared, and an osteochondral
defect was created at the femoral condyle in all rats.
platelet-rich fibrin was placed into the osteochondral defect of the right
knee, while the left knee joint was used as a control. Groups were sacrificed
after 4 and 8 weeks, respectively. 


Results:
According to the O'Driscoll score, there were no significant differences
between the right and left knee scores in group 4 weeks (p = 0.820). However, the right knee scores were
significantly different than the left knee scores in group 8 weeks (p < 0.001). Defects were completely filled with cartilage tissue
after 8 weeks in the platelet-rich fibrin group. 









Conclusions:
Similar to its role in various tissues, platelet-rich
fibrin is an effective biomaterial that enhances the healing of osteochondral
defects. 




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Makale detayları

Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model

Yazarlar: Hasan Metineren | Turan Cihan Dülgeroğlu

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Sağlık teşvikleri

Dergi: The European Research Journal 2019 Vol.5 Issue 2, pp.299-305

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000662830

Sıklık: İki Aylık

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.373385

Sayı

Yazarlar:

Hasan Metineren | Turan Cihan Dülgeroğlu

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2019 Vol.5 Issue 2, pp.299-305

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000662830

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.373385