The Effects of Insulin on Serum Levels of Apo A-I Containing Lipoprotein Particles in Syndrome X Patients With Coronary Heart Disease

Metin YILDIRIMKAYA

Makale detayları

The Effects of Insulin on Serum Levels of Apo A-I Containing Lipoprotein Particles in Syndrome X Patients With Coronary Heart Disease

Yazarlar:

Metin YILDIRIMKAYA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 4, pp.431-440

Belge Tipi:

Makale

Yayın Tarihi:

3/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757936

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Syndrome X consists of low serum high density lipoprotein-cholesterol (HDL-C), raised serum triglyceride, glucose intolerance, increased blood pressure, abdominal obesity and insulin resistance which is associated with increased risk of coronary heart disease (CHD). Apolipoprotein (apo) A-I containing lipoprotein particles, lipoprotein A-I (Lp A-I) and lipoprotein A-I:A-II (Lp A-I:A-II.) may have different metabolic functions. The purpose of this study was to   evaluate the relationship between insulin and apo A-I containing lipoproteins in syndrome X patients with or without CHD. We selected 38 male patients with syndrome X and divided into two groups: The one with CHD (n=21) and the other without CHD (n=17). Third group including 22 normal male subjects was the control group. We measured   fasting blood glucose, cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C), HDL-C, apo A-I, apo B, Lp A-I, Lp A-I:A-II and insulin, and 2-h glucose and insulin levels after a 75 g oral glucose tolerance test in all subjects. In both   syndrome X groups, serum levels of triglyceride, apo B, fasting glucose and insulin, and 2-h glucose and insulin were   significantly increased (p.

 

Syndrome X consists of low serum high density lipoprotein-cholesterol (HDL-C), raised serum triglyceride, glucose intolerance, increased blood pressure, abdominal obesity and insulin resistance which is associated with increased risk of coronary heart disease (CHD). Apolipoprotein (apo) A-I containing lipoprotein particles, lipoprotein A-I (Lp A-I) and lipoprotein A-I:A-II (Lp A-I:A-II.) may have different metabolic functions. The purpose of this study was to   evaluate the relationship between insulin and apo A-I containing lipoproteins in syndrome X patients with or without CHD. We selected 38 male patients with syndrome X and divided into two groups: The one with CHD (n=21) and the other without CHD (n=17). Third group including 22 normal male subjects was the control group. We measured   fasting blood glucose, cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C), HDL-C, apo A-I, apo B, Lp A-I, Lp A-I:A-II and insulin, and 2-h glucose and insulin levels after a 75 g oral glucose tolerance test in all subjects. In both   syndrome X groups, serum levels of triglyceride, apo B, fasting glucose and insulin, and 2-h glucose and insulin were   significantly increased (p.

Makale detayları

The Effects of Insulin on Serum Levels of Apo A-I Containing Lipoprotein Particles in Syndrome X Patients With Coronary Heart Disease

Yazarlar:

Metin YILDIRIMKAYA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 4, pp.431-440

Belge Tipi:

Makale

Yayın Tarihi:

3/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757936

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

High density lipoprotein-cholesterol

Apolipoprotein A-I

Lipoprotein A-I

Lipoprotein A-I:A-II

Glucose intolerance

Atherosclerosis

Insulin resistance

Hyperinsulinaemia.

Sayı

Makale detayları

Yazarlar: Metin YILDIRIMKAYA

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1999 Vol.29 Issue 4, pp.431-440

Belge Tipi: Makale

Yayın Tarihi: 3/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000757936

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Metin YILDIRIMKAYA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 4, pp.431-440

Belge Tipi:

Makale

Yayın Tarihi:

3/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757936

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144