Synthesis and Biological Activity of 4-(4-Hydroxybenzylidene)-2- (substituted styryl) oxazol-5-ones and Their o-glucosides

Vijay TAILE; Kishor HATZADE; Pravin Gaidhane And Vishwas INGLE

Makale detayları

Synthesis and Biological Activity of 4-(4-Hydroxybenzylidene)-2- (substituted styryl) oxazol-5-ones and Their o-glucosides

Yazarlar:

Vijay TAILE | Kishor HATZADE | Pravin Gaidhane And Vishwas INGLE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2009 Vol.33 Issue 2, pp.295-305

Belge Tipi:

Makale

Yayın Tarihi:

1/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000728344

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The 4-(4-hydroxybenzylidene)-2-methyl oxazol-5-ones 1 were  treated with various aldehydes in the presence of acetic acid to form  4-(4-hydroxybenzylidene)-2-(substituted styryl) oxazol-5-ones 2a-i,  which were glucosylated using a-acetobromoglucose as a glucosyl  donor to afford 4-(4-o-b-d-tetra-o-acetyl-glucoxybenzylidene)-2-  (substituted styryl) oxazol-5-ones 3a-i, which were deacetylated using  zinc acetate in absolute methanol to form 4-(4-o-b-d-glucoxybenzylidene)-  2-(substituted styryl) oxazol-5-ones 4a-i.  The compounds showed good  antimicrobial and antifungal activity.

 

The 4-(4-hydroxybenzylidene)-2-methyl oxazol-5-ones 1 were  treated with various aldehydes in the presence of acetic acid to form  4-(4-hydroxybenzylidene)-2-(substituted styryl) oxazol-5-ones 2a-i,  which were glucosylated using a-acetobromoglucose as a glucosyl  donor to afford 4-(4-o-b-d-tetra-o-acetyl-glucoxybenzylidene)-2-  (substituted styryl) oxazol-5-ones 3a-i, which were deacetylated using  zinc acetate in absolute methanol to form 4-(4-o-b-d-glucoxybenzylidene)-  2-(substituted styryl) oxazol-5-ones 4a-i.  The compounds showed good  antimicrobial and antifungal activity.

Makale detayları

Synthesis and Biological Activity of 4-(4-Hydroxybenzylidene)-2- (substituted styryl) oxazol-5-ones and Their o-glucosides

Yazarlar: Vijay TAILE | Kishor HATZADE | Pravin Gaidhane And Vishwas INGLE

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2009 Vol.33 Issue 2, pp.295-305

Belge Tipi: Makale

Yayın Tarihi: 1/2009

Belge Dili: Türkçe

Document ID (Org No.): 2000728344

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Vijay TAILE | Kishor HATZADE | Pravin Gaidhane And Vishwas INGLE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2009 Vol.33 Issue 2, pp.295-305

Belge Tipi:

Makale

Yayın Tarihi:

1/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000728344

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527