Desmopressin, Alarm, or Both? Evaluating Efficacy and Relapse in Children with Primary Monosymptomatic Nocturnal Enuresis

Aykut Akinci; Murat Can Karaburun

Makale detayları

Desmopressin, Alarm, or Both? Evaluating Efficacy and Relapse in Children with Primary Monosymptomatic Nocturnal Enuresis

Yazarlar:

Aykut Akinci | Murat Can Karaburun

Yayıncı:

Ankara University

Ana Başlıklar:

Pediatric Urology | Urology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 3, pp.239-243

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358157

pISSN:

0365-8104

Anahtar kelimeler:

Özet:

 Background: Monosymptomatic nocturnal enuresis MNE is a common pediatric condition that affects a childs self-esteem and daily family life. Both enuresis alarm and desmopressin are recommended as first-line treatment options, but their comparative effectiveness and relapse rates remain subjects of discussion. Aim: This study aimed to compare the short-term treatment outcomes and relapse rates of desmopressin, alarm therapy, and combination therapy in children with primary MNE. Materials and Methods: This retrospective two-center study included 202 children diagnosed with MNE between September 2022 and January 2025. Patients were grouped into desmopressin monotherapy n124, alarm therapy n45, and combination therapy n33. Demographic data, treatment responses, and relapse rates were evaluated. Results: Complete response rates were 39.5 for desmopressin, 42.2 for alarm therapy, and 63.6 for the combination group. Relapse occurred in 48.4 of the desmopressin group, 33.3 of the alarm group, and 30.3 of the combination group. Although the combination group showed higher response rates and lower relapse rates, these differences were not statistically significant p0.05. Conclusion: Desmopressin, alarm therapy, and their combination are effective options for the treatment of primary MNE. Combination therapy may provide added benefit in selected patients, but no clear superiority was demonstrated in this study. Treatment plans should consider individual factors such as nocturnal urine output and family compliance.

 Background: Monosymptomatic nocturnal enuresis MNE is a common pediatric condition that affects a childs self-esteem and daily family life. Both enuresis alarm and desmopressin are recommended as first-line treatment options, but their comparative effectiveness and relapse rates remain subjects of discussion. Aim: This study aimed to compare the short-term treatment outcomes and relapse rates of desmopressin, alarm therapy, and combination therapy in children with primary MNE. Materials and Methods: This retrospective two-center study included 202 children diagnosed with MNE between September 2022 and January 2025. Patients were grouped into desmopressin monotherapy n124, alarm therapy n45, and combination therapy n33. Demographic data, treatment responses, and relapse rates were evaluated. Results: Complete response rates were 39.5 for desmopressin, 42.2 for alarm therapy, and 63.6 for the combination group. Relapse occurred in 48.4 of the desmopressin group, 33.3 of the alarm group, and 30.3 of the combination group. Although the combination group showed higher response rates and lower relapse rates, these differences were not statistically significant p0.05. Conclusion: Desmopressin, alarm therapy, and their combination are effective options for the treatment of primary MNE. Combination therapy may provide added benefit in selected patients, but no clear superiority was demonstrated in this study. Treatment plans should consider individual factors such as nocturnal urine output and family compliance.

 Background: Monosymptomatic nocturnal enuresis MNE is a common pediatric condition that affects a childs self-esteem and daily family life. Both enuresis alarm and desmopressin are recommended as first-line treatment options, but their comparative effectiveness and relapse rates remain subjects of discussion. Aim: This study aimed to compare the short-term treatment outcomes and relapse rates of desmopressin, alarm therapy, and combination therapy in children with primary MNE. Materials and Methods: This retrospective two-center study included 202 children diagnosed with MNE between September 2022 and January 2025. Patients were grouped into desmopressin monotherapy n124, alarm therapy n45, and combination therapy n33. Demographic data, treatment responses, and relapse rates were evaluated. Results: Complete response rates were 39.5 for desmopressin, 42.2 for alarm therapy, and 63.6 for the combination group. Relapse occurred in 48.4 of the desmopressin group, 33.3 of the alarm group, and 30.3 of the combination group. Although the combination group showed higher response rates and lower relapse rates, these differences were not statistically significant p0.05. Conclusion: Desmopressin, alarm therapy, and their combination are effective options for the treatment of primary MNE. Combination therapy may provide added benefit in selected patients, but no clear superiority was demonstrated in this study. Treatment plans should consider individual factors such as nocturnal urine output and family compliance.

 Giriş: Monosemptomatik noktürnal enürezis MNE, çocuklarda özgüven ve aile düzenini olumsuz etkileyen yaygın bir durumdur. Enürezis alarmı ve desmopressin birinci basamak tedavi seçenekleri arasında yer almakta, ancak etkinlik ve nüks oranları hâlâ tartışılmaktadır. Amaç: Bu çalışmanın amacı, primer MNE tanılı çocuklarda desmopressin, alarm tedavisi ve kombine tedavinin kısa dönem tedavi sonuçları ile nüks oranlarını karşılaştırmaktır. Gereç ve Yöntem: Bu retrospektif iki merkezli çalışmaya, Eylül 2022 ile Ocak 2025 tarihleri arasında MNE tanısı alan 202 çocuk dahil edildi. Hastalar desmopressin monoterapisi n124, alarm tedavisi n45 ve kombine tedavi n33 gruplarına ayrıldı. Demografik veriler, tedavi yanıtları ve nüks oranları değerlendirildi. Bulgular: Tam yanıt oranları desmopressin grubunda 39,5, alarm grubunda 42,2 ve kombine grupta 63,6 idi. Nüks oranı desmopressin grubunda 48,4, alarm grubunda 33,3 ve kombine grupta 30,3 olarak saptandı. Kombine tedavi sayısal olarak daha iyi sonuç verse de fark istatistiksel olarak anlamlı değildi p0,05. Sonuç: Primer MNE tedavisinde desmopressin, alarm tedavisi ve kombine tedavi etkili seçeneklerdir. Kombine tedavi bazı hastalarda ek fayda sağlayabilir, ancak bu çalışmada belirgin bir üstünlük göstermemiştir. Tedavi planı, bireysel faktörler ve aile uyumu göz önünde bulundurularak yapılmalıdır.

Makale detayları

Desmopressin, Alarm, or Both? Evaluating Efficacy and Relapse in Children with Primary Monosymptomatic Nocturnal Enuresis

Yazarlar:

Aykut Akinci | Murat Can Karaburun

Yayıncı:

Ankara University

Ana Başlıklar:

Pediatric Urology | Urology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 3, pp.239-243

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358157

pISSN:

0365-8104

Monosymptomatic nocturnal enuresis

Desmopressin

Enuresis alarmMonosemptomatik Noktürnal Enürezis

Desmopressin

Enürezis Alarmı

Sayı

Makale detayları

Desmopressin, Alarm, or Both? Evaluating Efficacy and Relapse in Children with Primary Monosymptomatic Nocturnal Enuresis

Yazarlar: Aykut Akinci | Murat Can Karaburun

Yayıncı: Ankara University

Ana Başlıklar: Pediatric Urology | Urology

Dergi: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 3, pp.239-243

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001358157

pISSN: 0365-8104

Monosymptomatic nocturnal enuresis

Desmopressin

Enuresis alarmMonosemptomatik Noktürnal Enürezis

Desmopressin

Enürezis Alarmı

Sayı

Yazarlar:

Aykut Akinci | Murat Can Karaburun

Yayıncı:

Ankara University

Ana Başlıklar:

Pediatric Urology | Urology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 3, pp.239-243

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358157

pISSN:

0365-8104