Effects of Different Concentrations of Monensin on the Contractility  Changes of Guinea-pig Papillary Muscle

İsmail MERAL

Makale detayları

Effects of Different Concentrations of Monensin on the Contractility Changes of Guinea-pig Papillary Muscle

Yazarlar:

İsmail MERAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 1998 Vol.22 Issue 2, pp.145-150

Belge Tipi:

Makale

Yayın Tarihi:

1/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000772645

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Anahtar kelimeler:

Özet:

 

Effects of different concentrations of monensin on contraction amplitude (CA) which is the contraction force (CF), initial  contraction velocity (ICV), average contraction velocity (ACV) and initial relaxation velocity (IRV) of guinea-pig papillary muscle were  studied by using male guinea-pigs. Hearts were removed and papillary muscles were isolated from the right ventricles. The muscles  were then attached to a capacitance transducer, electrically connected to a Beckman recorder and the isometric contractions of  guinea-pig papillary muscles were recorded. The five hours of measurement in this experiment were divided into five periods (T0  was equilibration, T1, T2, T3 and T4 were respectively one, two, three and four hours after drug administration). Two µmol/l  monensin did not change any parameters at any time period. Although 12 µmol/l monensin did not change the CA, ACV or IRV at  any time period, it increased the ICV at T2. Seven µmol/l monensin, on the other hand, increased the CA and IRV at T2, T3 and T4  and the ICV and ACV at T1, T2, T3 and T4. It is concluded that the effect of monensin in guinea-pig papillary muscles is dose  dependent. It is also concluded that although the therapeutic range of monensin is very narrow, it should be considered as an alternative  drug for the treatment of congestive heart failure (CHF). However, more studies are needed to domenstrate the effectiveness  of monensin on the tratment of congestive heart failure.

 

Effects of different concentrations of monensin on contraction amplitude (CA) which is the contraction force (CF), initial  contraction velocity (ICV), average contraction velocity (ACV) and initial relaxation velocity (IRV) of guinea-pig papillary muscle were  studied by using male guinea-pigs. Hearts were removed and papillary muscles were isolated from the right ventricles. The muscles  were then attached to a capacitance transducer, electrically connected to a Beckman recorder and the isometric contractions of  guinea-pig papillary muscles were recorded. The five hours of measurement in this experiment were divided into five periods (T0  was equilibration, T1, T2, T3 and T4 were respectively one, two, three and four hours after drug administration). Two µmol/l  monensin did not change any parameters at any time period. Although 12 µmol/l monensin did not change the CA, ACV or IRV at  any time period, it increased the ICV at T2. Seven µmol/l monensin, on the other hand, increased the CA and IRV at T2, T3 and T4  and the ICV and ACV at T1, T2, T3 and T4. It is concluded that the effect of monensin in guinea-pig papillary muscles is dose  dependent. It is also concluded that although the therapeutic range of monensin is very narrow, it should be considered as an alternative  drug for the treatment of congestive heart failure (CHF). However, more studies are needed to domenstrate the effectiveness  of monensin on the tratment of congestive heart failure.

Makale detayları

Effects of Different Concentrations of Monensin on the Contractility Changes of Guinea-pig Papillary Muscle

Yazarlar:

İsmail MERAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 1998 Vol.22 Issue 2, pp.145-150

Belge Tipi:

Makale

Yayın Tarihi:

1/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000772645

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Monensin

papillary muscle

calcium

positive inotrope

guineapig

Sayı

Makale detayları

Effects of Different Concentrations of Monensin on the Contractility Changes of Guinea-pig Papillary Muscle

Yazarlar: İsmail MERAL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 1998 Vol.22 Issue 2, pp.145-150

Belge Tipi: Makale

Yayın Tarihi: 1/1998

Belge Dili: Türkçe

Document ID (Org No.): 2000772645

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Monensin

papillary muscle

calcium

positive inotrope

guineapig

Sayı

Yazarlar:

İsmail MERAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 1998 Vol.22 Issue 2, pp.145-150

Belge Tipi:

Makale

Yayın Tarihi:

1/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000772645

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128