Formulation, development and evaluation of an osmotic drug delivery system for lornoxicam

Shoaeb Mohammad Syed; Rajendra Panditrao Marathe

Makale detayları

Formulation, development and evaluation of an osmotic drug delivery system for lornoxicam

Yazarlar:

Shoaeb Mohammad Syed | Rajendra Panditrao Marathe

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 1, pp.10-21

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289619

pISSN:

2587-2087

Anahtar kelimeler:

Özet:

 Background and Aims: The current study aimed to develop an osmotic drug delivery system for Lornoxicam to prolong its release. Methods: Two different approaches were used for development of the osmotic drug delivery system; the first one was to for- mulate a controlled porosity osmotic tablet and the other was to design an elementary osmotic tablet. The controlled porosity osmotic tablets were coated with different concentrations of osmogents, a pore former, and varying coating thicknesses, and the effects were observed on the release. In the elementary osmotic pump, the tablets were drilled to make an orifice that creates pressure to release the drug by osmosis, and drug release was studied. Results: The formulations were evaluated for different parameters namely appearance, uniformity of weight, drug content, hardness, and drug release. Also, the effect of different osmotic agents responsible for developing the osmotic pressure such as sodium chloride and mannitol along with the different concentrations of pore-forming sorbitol were studied. A compari- son was made between the controlled porosity osmotic tablet in which the membrane coating contains water-soluble pore- forming polymers that leach when the membrane comes in contact with water thereby permitting water inside the wall and creating the osmotic pressure to release the drug, and the elementary osmotic tablet containing the osmotic agent sodium chloride coated with the rate-controlling semipermeable membrane, cellulose acetate, which contains an orifice of a critical size through which the drug is delivered. Conclusion: From the results, it was found that the developed formulation of the controlled porosity osmotic tablet was able to release Lornoxicam CPOP over 12 hours at zero-order kinetics and, the concentration of the osmotic agent, level of pore former, and thickness of the membrane coating are responsible for controlling the release of lornoxicam. The membrane coating was subjected to SEM analysis, which showed the formation of pores in the membrane. The developed controlled porosity osmotic pump tablet of lornoxicam was found to control the drug release for 12 hours.

 Background and Aims: The current study aimed to develop an osmotic drug delivery system for Lornoxicam to prolong its release. Methods: Two different approaches were used for development of the osmotic drug delivery system; the first one was to for- mulate a controlled porosity osmotic tablet and the other was to design an elementary osmotic tablet. The controlled porosity osmotic tablets were coated with different concentrations of osmogents, a pore former, and varying coating thicknesses, and the effects were observed on the release. In the elementary osmotic pump, the tablets were drilled to make an orifice that creates pressure to release the drug by osmosis, and drug release was studied. Results: The formulations were evaluated for different parameters namely appearance, uniformity of weight, drug content, hardness, and drug release. Also, the effect of different osmotic agents responsible for developing the osmotic pressure such as sodium chloride and mannitol along with the different concentrations of pore-forming sorbitol were studied. A compari- son was made between the controlled porosity osmotic tablet in which the membrane coating contains water-soluble pore- forming polymers that leach when the membrane comes in contact with water thereby permitting water inside the wall and creating the osmotic pressure to release the drug, and the elementary osmotic tablet containing the osmotic agent sodium chloride coated with the rate-controlling semipermeable membrane, cellulose acetate, which contains an orifice of a critical size through which the drug is delivered. Conclusion: From the results, it was found that the developed formulation of the controlled porosity osmotic tablet was able to release Lornoxicam CPOP over 12 hours at zero-order kinetics and, the concentration of the osmotic agent, level of pore former, and thickness of the membrane coating are responsible for controlling the release of lornoxicam. The membrane coating was subjected to SEM analysis, which showed the formation of pores in the membrane. The developed controlled porosity osmotic pump tablet of lornoxicam was found to control the drug release for 12 hours.

 Background and Aims: The current study aimed to develop an osmotic drug delivery system for Lornoxicam to prolong its release. Methods: Two different approaches were used for development of the osmotic drug delivery system; the first one was to for- mulate a controlled porosity osmotic tablet and the other was to design an elementary osmotic tablet. The controlled porosity osmotic tablets were coated with different concentrations of osmogents, a pore former, and varying coating thicknesses, and the effects were observed on the release. In the elementary osmotic pump, the tablets were drilled to make an orifice that creates pressure to release the drug by osmosis, and drug release was studied. Results: The formulations were evaluated for different parameters namely appearance, uniformity of weight, drug content, hardness, and drug release. Also, the effect of different osmotic agents responsible for developing the osmotic pressure such as sodium chloride and mannitol along with the different concentrations of pore-forming sorbitol were studied. A compari- son was made between the controlled porosity osmotic tablet in which the membrane coating contains water-soluble pore- forming polymers that leach when the membrane comes in contact with water thereby permitting water inside the wall and creating the osmotic pressure to release the drug, and the elementary osmotic tablet containing the osmotic agent sodium chloride coated with the rate-controlling semipermeable membrane, cellulose acetate, which contains an orifice of a critical size through which the drug is delivered. Conclusion: From the results, it was found that the developed formulation of the controlled porosity osmotic tablet was able to release Lornoxicam CPOP over 12 hours at zero-order kinetics and, the concentration of the osmotic agent, level of pore former, and thickness of the membrane coating are responsible for controlling the release of lornoxicam. The membrane coating was subjected to SEM analysis, which showed the formation of pores in the membrane. The developed controlled porosity osmotic pump tablet of lornoxicam was found to control the drug release for 12 hours.

 Background and Aims: The current study aimed to develop an osmotic drug delivery system for Lornoxicam to prolong its release. Methods: Two different approaches were used for development of the osmotic drug delivery system; the first one was to for- mulate a controlled porosity osmotic tablet and the other was to design an elementary osmotic tablet. The controlled porosity osmotic tablets were coated with different concentrations of osmogents, a pore former, and varying coating thicknesses, and the effects were observed on the release. In the elementary osmotic pump, the tablets were drilled to make an orifice that creates pressure to release the drug by osmosis, and drug release was studied. Results: The formulations were evaluated for different parameters namely appearance, uniformity of weight, drug content, hardness, and drug release. Also, the effect of different osmotic agents responsible for developing the osmotic pressure such as sodium chloride and mannitol along with the different concentrations of pore-forming sorbitol were studied. A compari- son was made between the controlled porosity osmotic tablet in which the membrane coating contains water-soluble pore- forming polymers that leach when the membrane comes in contact with water thereby permitting water inside the wall and creating the osmotic pressure to release the drug, and the elementary osmotic tablet containing the osmotic agent sodium chloride coated with the rate-controlling semipermeable membrane, cellulose acetate, which contains an orifice of a critical size through which the drug is delivered. Conclusion: From the results, it was found that the developed formulation of the controlled porosity osmotic tablet was able to release Lornoxicam CPOP over 12 hours at zero-order kinetics and, the concentration of the osmotic agent, level of pore former, and thickness of the membrane coating are responsible for controlling the release of lornoxicam. The membrane coating was subjected to SEM analysis, which showed the formation of pores in the membrane. The developed controlled porosity osmotic pump tablet of lornoxicam was found to control the drug release for 12 hours.

Makale detayları

Formulation, development and evaluation of an osmotic drug delivery system for lornoxicam

Yazarlar:

Shoaeb Mohammad Syed | Rajendra Panditrao Marathe

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 1, pp.10-21

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289619

pISSN:

2587-2087

Lornoxicam

Controlled porosity osmotic tablet

Elementary osmotic tablet

Drug Release

Osmotic agents

Pore former & Scanning Electron Microscopy

Sayı

Makale detayları

Formulation, development and evaluation of an osmotic drug delivery system for lornoxicam

Yazarlar: Shoaeb Mohammad Syed | Rajendra Panditrao Marathe

Yayıncı: Istanbul University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences

Dergi: İstanbul Journal of Pharmacy Vol.53 Issue 1, pp.10-21

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001289619

pISSN: 2587-2087

Lornoxicam

Controlled porosity osmotic tablet

Elementary osmotic tablet

Drug Release

Osmotic agents

Pore former & Scanning Electron Microscopy

Sayı

Yazarlar:

Shoaeb Mohammad Syed | Rajendra Panditrao Marathe

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 1, pp.10-21

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289619

pISSN:

2587-2087