Efficacy of Genetic Sonogram For Predicting Aneuploidy In a High-Risk Pregnancy Population

Fama TOKER; Bulat Aytek ŞIK; Yılda Arzu ABA

doi:https://doi.org/10.25000/acem.706112

Makale detayları

Efficacy of Genetic Sonogram For Predicting Aneuploidy In a High-Risk Pregnancy Population

Yazarlar:

Fama TOKER | Bulat Aytek ŞIK | Yılda Arzu ABA

Yayıncı:

Mustafa HASBAHÇECİ

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

Archives of Clinical and Experimental Medicine 2020 Vol.5 Issue 2, pp.69-74

Belge Tipi:

Makale

Yayın Tarihi:

8/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000675526

Sıklık:

Üç Yıllık

eISSN:

2564-6567

DOI:

https://doi.org/10.25000/acem.706112

Özet:

 

AİM: This study evaluates the efficacy of genetic sonogram for predicting aneuploidy in high-risk pregnancies.
 METHODS: This retrospective study included 1363 pregnant women who underwent a second trimester genetic sonogram due to high-risk pregnancy. Sensitivity, specificity, odds ratio, (+) and (-) likelihood ratios were calculated for each of the ultrasonography markers.
RESULTS: Among the high-risk pregnancy study population, there was no significant difference regarding advanced maternal age, presence of a relative with Down Syndrome, history of anomaly in the previous pregnancy, hyperechogenic bowels, pyelectasis, nuchal fold thickness > 5 mm, ventriculomegaly, choroid plexus cyst, single umbilical artery, or presence of right echogenic intracardiac focus between the control and aneuploidy groups (p>0.05). Tricuspid regurgitation, hypoplasia/absence of nasal bone, short femur, short humerus and left echogenic intracardiac focus were associated with increased risk of aneuploidy (p<0.05). The risk of aneuploidy was increased by 14.45 fold (95% CI 2.90-71.85) in cases with tricuspid regurgitation, 18.01 (5.46-59.32) fold by hypoplasia/absence of nasal bone, 9.74 (3.70-25.65) fold by presence of short femur, 11.42 (4.30-30.30) fold by presence of short humerus, and 4.20 (1.39-12.64) fold with the presence of left echogenic intracardiac focus. Analysis of combined markers showed that hypoplasia/absence of nasal bone + short humerus + tricuspid regurgitation resulted in the highest risk (OR = 11.20, LHR = 7.53).
CONCLUSION: İn some countries, where NIPT are not thoroughly diffused,Genetic sonography is recommended for Down syndrome risk modification in high-risk pregnancies.

Makale detayları

Efficacy of Genetic Sonogram For Predicting Aneuploidy In a High-Risk Pregnancy Population

Yazarlar: Fama TOKER | Bulat Aytek ŞIK | Yılda Arzu ABA

Yayıncı: Mustafa HASBAHÇECİ

Ana Başlıklar: Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi: Archives of Clinical and Experimental Medicine 2020 Vol.5 Issue 2, pp.69-74

Belge Tipi: Makale

Yayın Tarihi: 8/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000675526

Sıklık: Üç Yıllık

eISSN: 2564-6567

DOI: https://doi.org/10.25000/acem.706112

Sayı

Yazarlar:

Fama TOKER | Bulat Aytek ŞIK | Yılda Arzu ABA

Yayıncı:

Mustafa HASBAHÇECİ

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

Archives of Clinical and Experimental Medicine 2020 Vol.5 Issue 2, pp.69-74

Belge Tipi:

Makale

Yayın Tarihi:

8/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000675526

Sıklık:

Üç Yıllık

eISSN:

2564-6567

DOI:

https://doi.org/10.25000/acem.706112