The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease

Ayşe Nur Yıldırım; Ferhat Şirinyıldız; Recep Özmerdivenli

Makale detayları

The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease

Yazarlar:

Ayşe Nur Yıldırım | Ferhat Şirinyıldız | Recep Özmerdivenli

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences

Dergi:

Duzce Medical Journal Vol.25 Issue 2, pp.179-184

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289190

pISSN:

1307-671X

Anahtar kelimeler:

Özet:

 Aim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide VIP, which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divided into 4 groups. No intervention was made in the control group, rotenone was given to the RT group, rotenone and VIP 25 ngkg to the RTVIP group, and rotenone and naringenin 10 mgkg to the RTNG group. All treatments were administered intraperitoneally for 14 days. The hole and board method was used to show the effects of the Parkinsons model on behavior. On the last day of the experiment, motor tests were carried out with the hole and board apparatus. After the study was completed, biochemical analyzes were performed from brain tissue samples. Results: In comparison to the RT group, while the alpha-sync level in the RTNG p0.023, malondialdehyde MDA levels both in the RTVIP p0.039 and RTNG p0.032, and superoxide dismutase SOD inhibition in the RTVIP p0.042 groups decreased significantly, the 8-OHdG levels in the RTVIP p0.042 and RTNG p0.034 groups increased significantly. Statistically significant improvement was found both in biochemical and motor activities with the VIP and naringenin treatments applied. Conclusion: According to the results obtained, the symptoms of Parkinsons disease were formed biochemically by rotenone application. The administration of VIP and naringenin treatments has shown positive effects experimentally and has been promising as an adjunct treatment element in the fight against Parkinsons disease.

 Aim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide VIP, which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divided into 4 groups. No intervention was made in the control group, rotenone was given to the RT group, rotenone and VIP 25 ngkg to the RTVIP group, and rotenone and naringenin 10 mgkg to the RTNG group. All treatments were administered intraperitoneally for 14 days. The hole and board method was used to show the effects of the Parkinsons model on behavior. On the last day of the experiment, motor tests were carried out with the hole and board apparatus. After the study was completed, biochemical analyzes were performed from brain tissue samples. Results: In comparison to the RT group, while the alpha-sync level in the RTNG p0.023, malondialdehyde MDA levels both in the RTVIP p0.039 and RTNG p0.032, and superoxide dismutase SOD inhibition in the RTVIP p0.042 groups decreased significantly, the 8-OHdG levels in the RTVIP p0.042 and RTNG p0.034 groups increased significantly. Statistically significant improvement was found both in biochemical and motor activities with the VIP and naringenin treatments applied. Conclusion: According to the results obtained, the symptoms of Parkinsons disease were formed biochemically by rotenone application. The administration of VIP and naringenin treatments has shown positive effects experimentally and has been promising as an adjunct treatment element in the fight against Parkinsons disease.

 Aim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide VIP, which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divided into 4 groups. No intervention was made in the control group, rotenone was given to the RT group, rotenone and VIP 25 ngkg to the RTVIP group, and rotenone and naringenin 10 mgkg to the RTNG group. All treatments were administered intraperitoneally for 14 days. The hole and board method was used to show the effects of the Parkinsons model on behavior. On the last day of the experiment, motor tests were carried out with the hole and board apparatus. After the study was completed, biochemical analyzes were performed from brain tissue samples. Results: In comparison to the RT group, while the alpha-sync level in the RTNG p0.023, malondialdehyde MDA levels both in the RTVIP p0.039 and RTNG p0.032, and superoxide dismutase SOD inhibition in the RTVIP p0.042 groups decreased significantly, the 8-OHdG levels in the RTVIP p0.042 and RTNG p0.034 groups increased significantly. Statistically significant improvement was found both in biochemical and motor activities with the VIP and naringenin treatments applied. Conclusion: According to the results obtained, the symptoms of Parkinsons disease were formed biochemically by rotenone application. The administration of VIP and naringenin treatments has shown positive effects experimentally and has been promising as an adjunct treatment element in the fight against Parkinsons disease.

 Amaç: Bu çalışmanın amacı, çeşitli bilimsel çalışmalar ile etkili oldukları gösterilmiş olan naringenin ve vazointestinal peptidin VIP intraperitoneal olarak uygulanmasının ratlarda anti-Parkinson aktivitesi açısından değerlendirilmesidir. Gereç ve Yöntemler: Kırk sekiz adet Wistar albino dişi rat 4 gruba ayrıldı. Kontrol grubuna herhangi bir müdahale yapılmadı, RT grubuna rotenon verilirken, RTVIP grubuna rotenon ve VIP 25 ngkg ve RTNG grubuna ise rotenone ve naringenin 10 mgkg verildi. Tüm tedaviler 14 gün süreyle intraperitoneal yolla uygulandı. Parkinson modelinin davranış üzerindeki etkilerini göstermek için hole and board yöntemi kullanıldı. Deneyin son günü hole and board aparatı ile motor testleri yapıldı. Çalışma tamamlandıktan sonra alınan beyin dokusu örneklerinden biyokimyasal analizler yapıldı. Bulgular: RT grubuyla karşılaştırıldığında, RTNG p0,023 grubunda alfa senkronizasyon düzeyi, hem RTVIP p0,039 hem de RTNG p0,032 gruplarında malondialdehit MDA düzeyleri ve RTVIP p0,042 grubunda süperoksit dismutaz SOD inhibisyonu anlamlı olarak azalırken, RTVIP p0,042 ve RTNG p0,034 gruplarında ise 8-OHdG seviyeleri anlamlı şekilde arttı. Uygulanan VIP ve naringenin tedavileri ile hem biyokimyasal ve hem de motor aktivitelerinde istatistiksel olarak anlamlı şekilde düzelme saptandı. Sonuç: Elde edilen sonuçlara göre rotenon uygulaması ile Parkinson hastalığının semptomları biyokimyasal olarak oluşturulmuştur. VIP ve naringenin tedavilerinin uygulanması deneysel olarak olumlu etkiler göstermiştir ve Parkinson hastalığı ile mücadelede yardımcı bir tedavi unsuru olarak umut verici olmuştur.

Makale detayları

The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease

Yazarlar:

Ayşe Nur Yıldırım | Ferhat Şirinyıldız | Recep Özmerdivenli

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences

Dergi:

Duzce Medical Journal Vol.25 Issue 2, pp.179-184

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289190

pISSN:

1307-671X

Parkinson

rats

rotenone

vasointestinal peptideParkinson hastalığı

rotenon

sıçanlar

vazointestinal peptit

Sayı

Makale detayları

Yazarlar: Ayşe Nur Yıldırım | Ferhat Şirinyıldız | Recep Özmerdivenli

Yayıncı: Duzce University

Ana Başlıklar: Clinical Sciences

Dergi: Duzce Medical Journal Vol.25 Issue 2, pp.179-184

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001289190

pISSN: 1307-671X

Sayı

Yazarlar:

Ayşe Nur Yıldırım | Ferhat Şirinyıldız | Recep Özmerdivenli

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences

Dergi:

Duzce Medical Journal Vol.25 Issue 2, pp.179-184

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289190

pISSN:

1307-671X