Buccal Mucoadhesive System Formed By Liquid Crystals of Rasagiline Mesylate for Non- Oral Parkinson Treatment

Meliha Güneş; Gökçe Turan; Özgür Masalcı; Kevser Özgen Özer; Sinem Yaprak Karavana

Makale detayları

Buccal Mucoadhesive System Formed By Liquid Crystals of Rasagiline Mesylate for Non- Oral Parkinson Treatment

Yazarlar:

Meliha Güneş | Gökçe Turan | Özgür Masalcı | Kevser Özgen Özer | Sinem Yaprak Karavana

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Issue Special Issue / International Multidisciplinary Symposium on Drug Research and Development, DRD-2023, pp.46-53

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001323367

pISSN:

2458-8806

Anahtar kelimeler:

Özet:

 The morning off period in individuals with Parkinsons disease PD, characterized by challenges in receiving the appropriate dose for sleep, insufficient drug levels in the blood, and gastrointestinal issues, poses a significant challenge that impacts the overall quality of life for these patients. Based on research findings, these issues can be successfully addressed using non-oral treatments exclusively. Numerous mucoadhesive systems, such as lyotropic liquid crystals LCs, have been identified14. These systems can form an oblique connection with the buccal mucosa, thereby extending the residence time and optimizing drug bioavailability. The objective of this study is to prepare rasagiline mesylate RM, glyceryl monooleatepoloxamer 188 liquid crystal matrices GMOPlx188 LCs to improve the bioavailability of RM. The structures of the prepared formulations were examined by polarized light microscopy and SAXS analyzed. These formulations were also evaluated for several parameter such as appearance, visualization, content uniformity, homogenity, viscosity, mucoadhesion. Obtained results demonstrates the prospective of liquid crytals as a viable and alternative approach for effective RM buccal delivery.

 The morning off period in individuals with Parkinsons disease PD, characterized by challenges in receiving the appropriate dose for sleep, insufficient drug levels in the blood, and gastrointestinal issues, poses a significant challenge that impacts the overall quality of life for these patients. Based on research findings, these issues can be successfully addressed using non-oral treatments exclusively. Numerous mucoadhesive systems, such as lyotropic liquid crystals LCs, have been identified14. These systems can form an oblique connection with the buccal mucosa, thereby extending the residence time and optimizing drug bioavailability. The objective of this study is to prepare rasagiline mesylate RM, glyceryl monooleatepoloxamer 188 liquid crystal matrices GMOPlx188 LCs to improve the bioavailability of RM. The structures of the prepared formulations were examined by polarized light microscopy and SAXS analyzed. These formulations were also evaluated for several parameter such as appearance, visualization, content uniformity, homogenity, viscosity, mucoadhesion. Obtained results demonstrates the prospective of liquid crytals as a viable and alternative approach for effective RM buccal delivery.

 The morning off period in individuals with Parkinsons disease PD, characterized by challenges in receiving the appropriate dose for sleep, insufficient drug levels in the blood, and gastrointestinal issues, poses a significant challenge that impacts the overall quality of life for these patients. Based on research findings, these issues can be successfully addressed using non-oral treatments exclusively. Numerous mucoadhesive systems, such as lyotropic liquid crystals LCs, have been identified14. These systems can form an oblique connection with the buccal mucosa, thereby extending the residence time and optimizing drug bioavailability. The objective of this study is to prepare rasagiline mesylate RM, glyceryl monooleatepoloxamer 188 liquid crystal matrices GMOPlx188 LCs to improve the bioavailability of RM. The structures of the prepared formulations were examined by polarized light microscopy and SAXS analyzed. These formulations were also evaluated for several parameter such as appearance, visualization, content uniformity, homogenity, viscosity, mucoadhesion. Obtained results demonstrates the prospective of liquid crytals as a viable and alternative approach for effective RM buccal delivery.

 Uyku sırasında uygun dozu almada zorluklar, kandaki yetersiz ilaç seviyeleri ve mide-bağırsak sorunlarıyla karakterize edilen Parkinson hastalığı PD olan bireylerde sabah izin dönemi, bu kişilerin genel yaşam kalitesini etkileyen önemli bir sorun teşkil etmektedir. hastalar. Araştırma bulgularına göre, bu sorunlar yalnızca ağız dışı tedaviler kullanılarak başarılı bir şekilde çözülebilir. Liyotropik sıvı kristaller LCler gibi çok sayıda muko yapışkan sistem tanımlanmıştır. Bu sistemler yanak mukozası ile eğik bir bağlantı oluşturabilir, böylece kalış süresini uzatabilir ve ilacın biyoyararlanımını optimize edebilir. Bu çalışmanın amacı, RMnin biyoyararlılığını arttırmak için RM gliseril monooleatpoloksamer 188 sıvı kristal matrislerini GMOPlx188 LCler hazırlamaktır. Hazırlanan formülasyonların yapıları polarize ışık mikroskobu ile incelendi ve SAXS analizi yapıldı. Bu formülasyonlar ayrıca görünüm, görsellik, içerik tekdüzeliği, homojenlik, viskozite, mukoadezyon gibi çeşitli parametreler açısından da değerlendirildi. Elde edilen sonuçlar, etkin rasagilin mesilat bukkal dağıtımı için sıvı kristallerin uygulanabilir ve alternatif bir yaklaşım olduğunu göstermektedir.

Makale detayları

Buccal Mucoadhesive System Formed By Liquid Crystals of Rasagiline Mesylate for Non- Oral Parkinson Treatment

Yazarlar:

Meliha Güneş | Gökçe Turan | Özgür Masalcı | Kevser Özgen Özer | Sinem Yaprak Karavana

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Issue Special Issue / International Multidisciplinary Symposium on Drug Research and Development, DRD-2023, pp.46-53

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001323367

pISSN:

2458-8806

Liquid Crystals

Rasagiline mesylate

Glyceryl Monooleate

Parkinson

Buccal deliveryLikit kristal

Rasajilin mesilat

Gliseril monooleat

Parkinson

Bukkal uygulama

Sayı

Makale detayları

Yazarlar: Meliha Güneş | Gökçe Turan | Özgür Masalcı | Kevser Özgen Özer | Sinem Yaprak Karavana

Yayıncı: Hacettepe University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Hacettepe University Journal of the Faculty of Pharmacy Issue Special Issue / International Multidisciplinary Symposium on Drug Research and Development, DRD-2023, pp.46-53

Belge Tipi: Makale

Yayın Tarihi: 1/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001323367

pISSN: 2458-8806

Sayı

Yazarlar:

Meliha Güneş | Gökçe Turan | Özgür Masalcı | Kevser Özgen Özer | Sinem Yaprak Karavana

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Issue Special Issue / International Multidisciplinary Symposium on Drug Research and Development, DRD-2023, pp.46-53

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001323367

pISSN:

2458-8806