Evaluating the Utility of Hematologic-Inflammatory Indices in Assessing Nutritional Status in Children with Appetite Loss

Ömer Okuyan; Sinem Durmuş; Şeyma Dümür; Yusuf Elgörmüş; Hafize Uzun

Makale detayları

Evaluating the Utility of Hematologic-Inflammatory Indices in Assessing Nutritional Status in Children with Appetite Loss

Yazarlar:

Ömer Okuyan | Sinem Durmuş | Şeyma Dümür | Yusuf Elgörmüş | Hafize Uzun

Yayıncı:

Harran University

Ana Başlıklar:

Çocuk Endokrinolojisi | Çocuk Sağlığı ve Hastalıkları (Diğer)

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.531-537

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352424

pISSN:

1304-9623

Anahtar kelimeler:

Özet:

 Background: Appetite loss is a common concern in pediatric practice and may lead to malnutrition and delayed growth if persistent. While novel inflammatory indices such as neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, neutrophil percentage-to-albumin ratio NPAR, CRPAlbumin, and the CRP, albu-min, and lymphocyte CALLY index have been investigated in various adult diseases, their role in pediatric nutritional assessment remains unclear. This study aimed to evaluate the relationship between novel hema-tologic-inflammatory indices and nutritional status in children presenting with loss of appetite. Materials and Methods: A cross-sectional study was conducted between May 2024 and February 2025 in ter-tiary hospitals in Istanbul. Pediatric patients aged 216 years with appetite loss were included. Results: Children with loss of appetite had significantly lower albumin and CALLY index levels p  0.001 com-pared to controls. Additionally, they exhibited significantly higher neutrophil counts p  0.001, NLR p  0.001, PLR p  0.001, NPAR p  0.001, and CRPalbumin ratio p  0.012. Conclusion: Novel inflammatory markers such as NPAR, CRPAlbumin, and the CALLY index may offer valuable insight into the nutritional and inflammatory status of children with poor appetite. These indices could serve as accessible and cost-effective tools in the early identification of subclinical malnutrition in pediatric outpati-ent settings.

 Background: Appetite loss is a common concern in pediatric practice and may lead to malnutrition and delayed growth if persistent. While novel inflammatory indices such as neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, neutrophil percentage-to-albumin ratio NPAR, CRPAlbumin, and the CRP, albu-min, and lymphocyte CALLY index have been investigated in various adult diseases, their role in pediatric nutritional assessment remains unclear. This study aimed to evaluate the relationship between novel hema-tologic-inflammatory indices and nutritional status in children presenting with loss of appetite. Materials and Methods: A cross-sectional study was conducted between May 2024 and February 2025 in ter-tiary hospitals in Istanbul. Pediatric patients aged 216 years with appetite loss were included. Results: Children with loss of appetite had significantly lower albumin and CALLY index levels p  0.001 com-pared to controls. Additionally, they exhibited significantly higher neutrophil counts p  0.001, NLR p  0.001, PLR p  0.001, NPAR p  0.001, and CRPalbumin ratio p  0.012. Conclusion: Novel inflammatory markers such as NPAR, CRPAlbumin, and the CALLY index may offer valuable insight into the nutritional and inflammatory status of children with poor appetite. These indices could serve as accessible and cost-effective tools in the early identification of subclinical malnutrition in pediatric outpati-ent settings.

 Background: Appetite loss is a common concern in pediatric practice and may lead to malnutrition and delayed growth if persistent. While novel inflammatory indices such as neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, neutrophil percentage-to-albumin ratio NPAR, CRPAlbumin, and the CRP, albu-min, and lymphocyte CALLY index have been investigated in various adult diseases, their role in pediatric nutritional assessment remains unclear. This study aimed to evaluate the relationship between novel hema-tologic-inflammatory indices and nutritional status in children presenting with loss of appetite. Materials and Methods: A cross-sectional study was conducted between May 2024 and February 2025 in ter-tiary hospitals in Istanbul. Pediatric patients aged 216 years with appetite loss were included. Results: Children with loss of appetite had significantly lower albumin and CALLY index levels p  0.001 com-pared to controls. Additionally, they exhibited significantly higher neutrophil counts p  0.001, NLR p  0.001, PLR p  0.001, NPAR p  0.001, and CRPalbumin ratio p  0.012. Conclusion: Novel inflammatory markers such as NPAR, CRPAlbumin, and the CALLY index may offer valuable insight into the nutritional and inflammatory status of children with poor appetite. These indices could serve as accessible and cost-effective tools in the early identification of subclinical malnutrition in pediatric outpati-ent settings.

 Amaç: İştah kaybı, çocuk sağlığı pratiğinde sık karşılaşılan bir durumdur ve uzun süreli olduğunda malnütrisyon ve büyüme geriliğine yol açabilir. Nötrofil-lenfosit oranı NLO, trombosit-lenfosit oranı TLO, nötrofil yüzdesialbumin oranı NYAO, C-reaktif protein CRP, CRPAlbümin oranı, albümin ve lenfosit değerlerinden oluşan CALLY indeksi gibi yeni inflamatuar indeksler, çeşitli erişkin hastalıklar-da araştırılmış olsa da, çocuklarda beslenme durumunun değerlendirilmesindeki rolleri net değildir. Bu çalışmada, iştahsızlık şikayeti ile başvuran çocuklarda yeni hematolojik-inflamatuar indeksler ile beslenme durumu arasındaki ilişki değerlendirilmiştir. Materyal ve Metod: Bu kesitsel çalışma Mayıs 2024 ile Şubat 2025 tarihleri arasında İstanbuldaki üçüncü basamak hastanede gerçekleştirildi. İştahsızlık şikayeti olan 216 yaş arası çocuklar çalışmaya dahil edildi. Bulgular: İştah kaybı olan çocuklarda, kontrol grubuna kıyasla albümin ve CALLY indeksi anlamlı de-recede daha düşüktü p  0.001. Ayrıca nötrofil sayısı p  0.001, NLO p  0.001, TLO p  0.001, NYAO p  0.001 ve CRPAlbümin oranı p  0.012 anlamlı olarak daha yüksekti. Sonuç: NYAO, CRPAlbümin oranı ve CALLY indeksi gibi yeni inflamatuar göstergeler, iştahsız çocuklarda beslenme ve inflamatuar duruma dair önemli bilgiler sunabilir. Bu indeksler, çocuk poli-kliniklerinde subklinik malnütrisyonun erken tanısında kolay erişilebilir ve maliyet etkin araçlar olabilir.

Makale detayları

Evaluating the Utility of Hematologic-Inflammatory Indices in Assessing Nutritional Status in Children with Appetite Loss

Yazarlar:

Ömer Okuyan | Sinem Durmuş | Şeyma Dümür | Yusuf Elgörmüş | Hafize Uzun

Yayıncı:

Harran University

Ana Başlıklar:

Çocuk Endokrinolojisi | Çocuk Sağlığı ve Hastalıkları (Diğer)

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.531-537

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352424

pISSN:

1304-9623

appetite loss

CALLY index

children

CRP/Albumin

NLR

NPAR

PLRappetite loss

CALLY index

children

CRP/Albumin

NLR

NPAR

PLR

Sayı

Makale detayları

Yazarlar: Ömer Okuyan | Sinem Durmuş | Şeyma Dümür | Yusuf Elgörmüş | Hafize Uzun

Yayıncı: Harran University

Ana Başlıklar: Çocuk Endokrinolojisi | Çocuk Sağlığı ve Hastalıkları (Diğer)

Dergi: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.531-537

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001352424

pISSN: 1304-9623

Sayı

Yazarlar:

Ömer Okuyan | Sinem Durmuş | Şeyma Dümür | Yusuf Elgörmüş | Hafize Uzun

Yayıncı:

Harran University

Ana Başlıklar:

Çocuk Endokrinolojisi | Çocuk Sağlığı ve Hastalıkları (Diğer)

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.531-537

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352424

pISSN:

1304-9623