Could Hemokinin-1 (HK-1) be a Novel Candidate Biomarker for Sarcoidosis?

Celalettin Korkmaz; Turan Akdağ

Makale detayları

Could Hemokinin-1 (HK-1) be a Novel Candidate Biomarker for Sarcoidosis?

Yazarlar:

Celalettin Korkmaz | Turan Akdağ

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 4, pp.456-460

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293936

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Aim: Sarcoidosis is a systemic inflammatory disease and characterized by the presence of non-caseating granulomas which may affect all organs in the body. Some studies suggest an association between peptides and sarcoidosis. The goal of the study was to investigate the biomarker values of serum hemokinin-1 HK-1 and adropin levels in sarcoidosis and to assess their role in the disease course. Patients and Methods: The study was carried out in a university hospital between April 2021 and February 2022. Thirty-eight patients with diagnosed sarcoidosis 14 men and 24 women and 38 healthy 14 men and 24 women individuals were enrolled in the study. Demographic characteristics, age, gender, disease duration, and extrapulmonary involvement of the patients were enrolled. HK-1 and adropin levels were measured via the sandwich ELISA enzyme linked immunosorbent assay method. Results: HK-1 level was elevated in the sarcoidosis patients than in the healthy individuals, these differences were significant statistically 0.670.23 and 0.540.24 ngml, p0.012. The serum levels of adropin were measured as 207.84246.72 ngL in the sarcoidosis patients group and 151.16171.76 ngL in the healthy individuals group. No significant differences were determined in terms of the adropin levels in the patients group when compared to the healthy individuals group p0.076. Serum adropin were negatively correlated with BAL CD4 levels r-,880 and p0.002 and positively correlated with BAL CD8 levels r,697 and p0.037. Conclusions: At the study, it is determined that patients with sarcoidosis show significantly higher HK-1 levels than healthy controls, and HK-1 may be a useful non-invasive diagnostic biomarker for this disease. From the literature, serum HK-1 and adropin levels have not been investigated in sarcoidosis, yet. To clarify this topic, further and larger size studies are needed.

 Aim: Sarcoidosis is a systemic inflammatory disease and characterized by the presence of non-caseating granulomas which may affect all organs in the body. Some studies suggest an association between peptides and sarcoidosis. The goal of the study was to investigate the biomarker values of serum hemokinin-1 HK-1 and adropin levels in sarcoidosis and to assess their role in the disease course. Patients and Methods: The study was carried out in a university hospital between April 2021 and February 2022. Thirty-eight patients with diagnosed sarcoidosis 14 men and 24 women and 38 healthy 14 men and 24 women individuals were enrolled in the study. Demographic characteristics, age, gender, disease duration, and extrapulmonary involvement of the patients were enrolled. HK-1 and adropin levels were measured via the sandwich ELISA enzyme linked immunosorbent assay method. Results: HK-1 level was elevated in the sarcoidosis patients than in the healthy individuals, these differences were significant statistically 0.670.23 and 0.540.24 ngml, p0.012. The serum levels of adropin were measured as 207.84246.72 ngL in the sarcoidosis patients group and 151.16171.76 ngL in the healthy individuals group. No significant differences were determined in terms of the adropin levels in the patients group when compared to the healthy individuals group p0.076. Serum adropin were negatively correlated with BAL CD4 levels r-,880 and p0.002 and positively correlated with BAL CD8 levels r,697 and p0.037. Conclusions: At the study, it is determined that patients with sarcoidosis show significantly higher HK-1 levels than healthy controls, and HK-1 may be a useful non-invasive diagnostic biomarker for this disease. From the literature, serum HK-1 and adropin levels have not been investigated in sarcoidosis, yet. To clarify this topic, further and larger size studies are needed.

 Aim: Sarcoidosis is a systemic inflammatory disease and characterized by the presence of non-caseating granulomas which may affect all organs in the body. Some studies suggest an association between peptides and sarcoidosis. The goal of the study was to investigate the biomarker values of serum hemokinin-1 HK-1 and adropin levels in sarcoidosis and to assess their role in the disease course. Patients and Methods: The study was carried out in a university hospital between April 2021 and February 2022. Thirty-eight patients with diagnosed sarcoidosis 14 men and 24 women and 38 healthy 14 men and 24 women individuals were enrolled in the study. Demographic characteristics, age, gender, disease duration, and extrapulmonary involvement of the patients were enrolled. HK-1 and adropin levels were measured via the sandwich ELISA enzyme linked immunosorbent assay method. Results: HK-1 level was elevated in the sarcoidosis patients than in the healthy individuals, these differences were significant statistically 0.670.23 and 0.540.24 ngml, p0.012. The serum levels of adropin were measured as 207.84246.72 ngL in the sarcoidosis patients group and 151.16171.76 ngL in the healthy individuals group. No significant differences were determined in terms of the adropin levels in the patients group when compared to the healthy individuals group p0.076. Serum adropin were negatively correlated with BAL CD4 levels r-,880 and p0.002 and positively correlated with BAL CD8 levels r,697 and p0.037. Conclusions: At the study, it is determined that patients with sarcoidosis show significantly higher HK-1 levels than healthy controls, and HK-1 may be a useful non-invasive diagnostic biomarker for this disease. From the literature, serum HK-1 and adropin levels have not been investigated in sarcoidosis, yet. To clarify this topic, further and larger size studies are needed.

 Amaç: Sarkoidoz, vücuttaki bütün organları etkileyebilen, kazeifiye olmayan granülomların varlığı ile karakterize, nedeni bilinmeyen sistemik inflamatuar bir hastalıktır. Bazı çalışmalar peptitler ve sarkoidoz arasında bir ilişki olduğunu önermektedir. Bu çalışmanın amacı sarkoidozda serum hemokinin-1 HK-1 ve adropin düzeylerinin tanısal değerlerini araştırmak ve hastalıkta rolünü değerlendirmektir. Hastalar ve Metod: Çalışma Nisan 2021-Şubat 2022 tarihleri arasında bir üniversite hastanesinde gerçekleştirildi. Çalışmaya sarkoidoz tanılı 38 hasta 14 erkek, 24 kadın ve 38 sağlıklı 14 erkek, 24 kadın birey alındı. Hastaların demografik özellikleri, yaşı, cinsiyeti, hastalık süresi ve akciğer dışı tutulumu kaydedildi. HK-1 ve adropin düzeyleri, sandviç ELISA enzyme linked immunosorbent assay yöntemi ile belirlendi. Bulgular: Sarkoidozlu hastalarda HK-1 seviyesi sağlıklı bireylere göre daha yüksekti, aradaki fark istatistiksel olarak anlamlıydı 0,670,23 ve 0,540,24 ngml, p0,012. Serum adropin düzeyleri sarkoidoz hasta grubunda 207,84246,72 ngL, sağlıklı kontrol grubunda 151,16171,76 ngL olarak belirlendi. Sarkoidozlu hastalarının adropin seviyeleri ise sağlıklı bireylere göre anlamlı fark belirlenmedi p0,076. Serum adropin seviyeleri, BAL CD4 seviyeleri ile negatif r-,880 ve p0.002 ve BAL CD8 seviyeleri ile pozitif korrelasyon gösterdi r,697 ve p0.037. Sonuç: Çalışmada sarkoidozlu hastaların sağlıklı kontrollere göre anlamlı olarak daha yüksek HK-1 seviyeleri gösterdiği ve HK-1in bu hastalık için invaziv olmayan yararlı bir tanısal biyobelirteç olabileceği belirlendi. Literatürde henüz sarkoidozda serum HK-1 ve adropin düzeyleri henüz araştırılmamıştır. Bu konuyu açıklığa kavuşturmak için daha fazla ve geniş çaplı çalışmalara ihtiyaç vardır.

Makale detayları

Could Hemokinin-1 (HK-1) be a Novel Candidate Biomarker for Sarcoidosis?

Yazarlar:

Celalettin Korkmaz | Turan Akdağ

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 4, pp.456-460

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293936

pISSN:

2602-3741

Sarkoidosis

hemokinin-1

adropinSarkoidoz

hemokinin-1

adropin

Sayı

Makale detayları

Could Hemokinin-1 (HK-1) be a Novel Candidate Biomarker for Sarcoidosis?

Yazarlar: Celalettin Korkmaz | Turan Akdağ

Yayıncı: Selcuk University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Genel Tıp Dergisi Vol.33 Issue 4, pp.456-460

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293936

pISSN: 2602-3741

Sarkoidosis

hemokinin-1

adropinSarkoidoz

hemokinin-1

adropin

Sayı

Yazarlar:

Celalettin Korkmaz | Turan Akdağ

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 4, pp.456-460

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293936

pISSN:

2602-3741