Investigation of Receptor-Ligand Interaction of Cannabidiol by Molecular Docking Method

Emre Fatih Ediz; Meltem Demirel Kars

Makale detayları

Investigation of Receptor-Ligand Interaction of Cannabidiol by Molecular Docking Method

Yazarlar:

Emre Fatih Ediz | Meltem Demirel Kars

Yayıncı:

Giresun University

Ana Başlıklar:

Mühendislik

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.13 Issue 2, pp.398-414

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290997

pISSN:

2564-7377

Anahtar kelimeler:

Özet:

 Cannabidiol is a cannabinoid that has low affinity for CB1 and CB2 receptors and does not have psychoactive properties. It also exhibits activity with G protein-coupled receptors, serotonin receptors and opioid receptors. Therefore, cannabidiol has been used for a long time in the treatment of neuronal diseases such as anxiety, depression, refractory epilepsy, nervous system diseases such as Parkinsons disease, Alzheimers disease, amyotrophic lateral sclerosis, and immune system diseases such as inflammatory disorders. In this study, two classical cannabinoid receptors, CB1 and CB2, and Human Delta-Opioid Receptor δ-OP, NociceptinOrphanin FQ receptor G protein-coupled receptor 55 - GPR55, Vanilloid Receptor Transient receptor potential vanilloid receptor1 -TRPV1 and Serotonin 1A receptor 5-HT1A were selected in addition to the so called receptors, as a result of literature review. As a result of molecular docking studies, it has been revealed that CBD is a molecule with significant affinity for CB1, CB2, δ-OP, GPR55, TRPV1 and 5-HT1A receptors.

 Cannabidiol is a cannabinoid that has low affinity for CB1 and CB2 receptors and does not have psychoactive properties. It also exhibits activity with G protein-coupled receptors, serotonin receptors and opioid receptors. Therefore, cannabidiol has been used for a long time in the treatment of neuronal diseases such as anxiety, depression, refractory epilepsy, nervous system diseases such as Parkinsons disease, Alzheimers disease, amyotrophic lateral sclerosis, and immune system diseases such as inflammatory disorders. In this study, two classical cannabinoid receptors, CB1 and CB2, and Human Delta-Opioid Receptor δ-OP, NociceptinOrphanin FQ receptor G protein-coupled receptor 55 - GPR55, Vanilloid Receptor Transient receptor potential vanilloid receptor1 -TRPV1 and Serotonin 1A receptor 5-HT1A were selected in addition to the so called receptors, as a result of literature review. As a result of molecular docking studies, it has been revealed that CBD is a molecule with significant affinity for CB1, CB2, δ-OP, GPR55, TRPV1 and 5-HT1A receptors.

 Cannabidiol is a cannabinoid that has low affinity for CB1 and CB2 receptors and does not have psychoactive properties. It also exhibits activity with G protein-coupled receptors, serotonin receptors and opioid receptors. Therefore, cannabidiol has been used for a long time in the treatment of neuronal diseases such as anxiety, depression, refractory epilepsy, nervous system diseases such as Parkinsons disease, Alzheimers disease, amyotrophic lateral sclerosis, and immune system diseases such as inflammatory disorders. In this study, two classical cannabinoid receptors, CB1 and CB2, and Human Delta-Opioid Receptor δ-OP, NociceptinOrphanin FQ receptor G protein-coupled receptor 55 - GPR55, Vanilloid Receptor Transient receptor potential vanilloid receptor1 -TRPV1 and Serotonin 1A receptor 5-HT1A were selected in addition to the so called receptors, as a result of literature review. As a result of molecular docking studies, it has been revealed that CBD is a molecule with significant affinity for CB1, CB2, δ-OP, GPR55, TRPV1 and 5-HT1A receptors.

 Kanabidiol, CB1 ve CB2 reseptörlerine düşük bağlanma eğilimine afiniteye sahip ve psikoaktif özellikleri olmayan bir kanabinoiddir. Ayrıca G proteinine bağlı reseptörler, serotonin reseptörleri ve opioid reseptörleri ile de aktivite göstermektedir. Bu nedenle kanabidiol uzun zamandır anksiyete, depresyon, refrakter epilepsi gibi nöronal hastalıkların, Parkinson, Alzheimer hastalığı, amyotrofik lateral skleroz gibi sinir sistemi hastalıklarının, enflamatuvar bozukluklar gibi bağışıklık sistemi hastalıklarının tedavisinde kullanılmaktadır. Ayrıca opioid reseptörleri ile güçlü aktivitesi sayesinde yoksunluk sendromu tedavisinde de kullanılmaktadır. Bu çalışmada iki klasik kanabinoid reseptörü olan CB1 ve CB2, bunlara ilaveten literatür taramaları sonucunda, İnsan Delta-Opioid Reseptörü δ-OP, NosiseptinOrfanin FQ receptor G protein-coupled receptor 55 - GPR55, Vanilloid Reseptörü Transient receptor potential vanilloid receptor1 -TRPV1 ve Serotonin 1A reseptörü 5-HT1A tercih edilmiştir. Yapılan moleküler yerleştirme çalışmaları sonucunda CBDnin CB1, CB2, δ-OP, GPR55, TRPV1 ve 5-HT1A reseptörleri için önemli afiniteye sahip bir molekül olduğu gösterilmiştir.

Makale detayları

Investigation of Receptor-Ligand Interaction of Cannabidiol by Molecular Docking Method

Yazarlar:

Emre Fatih Ediz | Meltem Demirel Kars

Yayıncı:

Giresun University

Ana Başlıklar:

Mühendislik

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.13 Issue 2, pp.398-414

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290997

pISSN:

2564-7377

Cannabidiol

ligand

receptor

molecular dockingKanabidiol

ligant

reseptör

moleküler yerleştirme

Sayı

Makale detayları

Yazarlar: Emre Fatih Ediz | Meltem Demirel Kars

Yayıncı: Giresun University

Ana Başlıklar: Mühendislik

Dergi: Karadeniz Fen Bilimleri Dergisi Vol.13 Issue 2, pp.398-414

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001290997

pISSN: 2564-7377

Sayı

Yazarlar:

Emre Fatih Ediz | Meltem Demirel Kars

Yayıncı:

Giresun University

Ana Başlıklar:

Mühendislik

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.13 Issue 2, pp.398-414

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290997

pISSN:

2564-7377