Predictive Role of Delta Neutrophil Index in Endometrial Cancer: A Promising Biomarker for Diagnosis

Caner Kose; Büşra Körpe; Vakkas Korkmaz; Yaprak Ustun

Makale detayları

Predictive Role of Delta Neutrophil Index in Endometrial Cancer: A Promising Biomarker for Diagnosis

Yazarlar:

Caner Kose | Büşra Körpe | Vakkas Korkmaz | Yaprak Ustun

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences

Dergi:

Duzce Medical Journal Vol.25 Issue 2, pp.185-188

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289189

pISSN:

1307-671X

Anahtar kelimeler:

Özet:

 Aim: This study aimed to explore the potential of delta neutrophil index DNI as a predictive biomarker for the development of endometrial cancer EC in women with endometrial intraepithelial neoplasia EIN. Material and Methods: This retrospective study included 139 women diagnosed with EIN who underwent surgery between 2019 and 2022. Demographic data, medical history, and laboratory parameters, including DNI, were collected from the patients medical records. Patients with other types of cancer, a history of steroid use, inflammatory, hematologic, or autoimmune diseases, or missing data were excluded. The patients pathology reports were reviewed, and patients were divided into three groups by the final pathological diagnosis, benign n64, EIN n66, and EC n39. Results: The mean DNI level of the EC group was found to be significantly higher than the EIN and benign groups 4.852.31, 2.310.89, 1.481.03, p0.001, respectively. The optimal cut-off value of DNI was determined as 2.75 with 82.1 sensitivity and 73.8 specificity. DNI levels 2.75 were found to be associated with an 11.56-fold 95 CI: 4-59-29.09, p0.001 increased risk of EC. Smoking and postmenopausal status were also identified as independent risk factors for EC. Patients with smoking had a 4.13-fold 95 CI: 1.54-11.01, p0.005, and postmenopausal status had a 2.8-fold 95 CI: 1.87-9.04, p0.034 increased risk of EC. Conclusion: The results of this study suggest that DNI may be a useful biomarker for predicting the risk of EC. The results also confirm that smoking and postmenopausal status are independent risk factors for EC.

 Aim: This study aimed to explore the potential of delta neutrophil index DNI as a predictive biomarker for the development of endometrial cancer EC in women with endometrial intraepithelial neoplasia EIN. Material and Methods: This retrospective study included 139 women diagnosed with EIN who underwent surgery between 2019 and 2022. Demographic data, medical history, and laboratory parameters, including DNI, were collected from the patients medical records. Patients with other types of cancer, a history of steroid use, inflammatory, hematologic, or autoimmune diseases, or missing data were excluded. The patients pathology reports were reviewed, and patients were divided into three groups by the final pathological diagnosis, benign n64, EIN n66, and EC n39. Results: The mean DNI level of the EC group was found to be significantly higher than the EIN and benign groups 4.852.31, 2.310.89, 1.481.03, p0.001, respectively. The optimal cut-off value of DNI was determined as 2.75 with 82.1 sensitivity and 73.8 specificity. DNI levels 2.75 were found to be associated with an 11.56-fold 95 CI: 4-59-29.09, p0.001 increased risk of EC. Smoking and postmenopausal status were also identified as independent risk factors for EC. Patients with smoking had a 4.13-fold 95 CI: 1.54-11.01, p0.005, and postmenopausal status had a 2.8-fold 95 CI: 1.87-9.04, p0.034 increased risk of EC. Conclusion: The results of this study suggest that DNI may be a useful biomarker for predicting the risk of EC. The results also confirm that smoking and postmenopausal status are independent risk factors for EC.

 Aim: This study aimed to explore the potential of delta neutrophil index DNI as a predictive biomarker for the development of endometrial cancer EC in women with endometrial intraepithelial neoplasia EIN. Material and Methods: This retrospective study included 139 women diagnosed with EIN who underwent surgery between 2019 and 2022. Demographic data, medical history, and laboratory parameters, including DNI, were collected from the patients medical records. Patients with other types of cancer, a history of steroid use, inflammatory, hematologic, or autoimmune diseases, or missing data were excluded. The patients pathology reports were reviewed, and patients were divided into three groups by the final pathological diagnosis, benign n64, EIN n66, and EC n39. Results: The mean DNI level of the EC group was found to be significantly higher than the EIN and benign groups 4.852.31, 2.310.89, 1.481.03, p0.001, respectively. The optimal cut-off value of DNI was determined as 2.75 with 82.1 sensitivity and 73.8 specificity. DNI levels 2.75 were found to be associated with an 11.56-fold 95 CI: 4-59-29.09, p0.001 increased risk of EC. Smoking and postmenopausal status were also identified as independent risk factors for EC. Patients with smoking had a 4.13-fold 95 CI: 1.54-11.01, p0.005, and postmenopausal status had a 2.8-fold 95 CI: 1.87-9.04, p0.034 increased risk of EC. Conclusion: The results of this study suggest that DNI may be a useful biomarker for predicting the risk of EC. The results also confirm that smoking and postmenopausal status are independent risk factors for EC.

 Amaç: Bu çalışmanın amacı, endometriyal intraepitelyal neoplazi EIN tanısı almış olan kadınlarda delta nötrofil indeksinin DNI endometriyal kanser endometrial cancer, EC gelişimi için bir öngörücü biyobelirteç olarak potansiyelini değerlendirmektir. Gereç ve Yöntemler: Bu retrospektif çalışmaya, 2019 ve 2022 yılları arasında EIN tanısı almış ve cerrahi geçirmiş olan 139 kadın dahil edilmiştir. Demografik veriler, tıbbi öykü ve DNI da dahil olmak üzere laboratuvar parametreleri hastaların tıbbi kayıtlarından toplanmıştır. Başka kanser türüne sahip olan hastalar, steroid kullanım öyküsü olanlar, enflamatuar, hematolojik veya otoimmün hastalığı olanlar ve eksik verisi olan hastalar çalışmadan çıkarılmıştır. Hastaların patoloji raporları incelenmiş ve hastalar nihai patoloji tanılarına göre benign n64, EIN n66 ve EC n39 olmak üzere üç gruba ayrılmıştır. Bulgular: EC grubunun ortalama DNI düzeyi, EIN ve benign gruplarına göre anlamlı olarak daha yüksek bulundu sırasıyla 4,852,31; 2,310,89 ve 1,481,03; p0,001. DNI için optimal kesim değeri 82,1 sensitivite ve 73,8 spesifite ile 2,75 olarak belirlendi. DNI düzeyi 2,75 olmanın 11,56 kat 95 GA: 4,59-29,09; p0,001 artmış EC riski ile ilişkili olduğu bulundu. Sigara içmek ve postmenopozal durum da EC için bağımsız risk faktörleri olarak belirlendi. Sigara içen hastalarda 4,13 kat 95 GA: 1,54-11,01; p0,005 ve postmenopozal durumda ise 2,8 kat 95 CI: 1,87-9,04; p0,034 daha fazla EC riski vardı. Sonuç: Bu çalışmanın sonuçları DNInin EC riskini öngörmede kullanılabilir bir biyobelirteç olabileceğini öne sürmektedir. Sonuçlar ayrıca sigara içmenin ve menopoz sonrası durumun da EC için bağımsız risk faktörleri olduğunu doğrulamaktadır.

Makale detayları

Predictive Role of Delta Neutrophil Index in Endometrial Cancer: A Promising Biomarker for Diagnosis

Yazarlar:

Caner Kose | Büşra Körpe | Vakkas Korkmaz | Yaprak Ustun

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences

Dergi:

Duzce Medical Journal Vol.25 Issue 2, pp.185-188

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289189

pISSN:

1307-671X

Biomarker

Endometrial cancer

Endometrial hyperplasiaBiyobelirteç

Endometriyal Kanser

Endometriyal hiperplazi

Sayı

Makale detayları

Predictive Role of Delta Neutrophil Index in Endometrial Cancer: A Promising Biomarker for Diagnosis

Yazarlar: Caner Kose | Büşra Körpe | Vakkas Korkmaz | Yaprak Ustun

Yayıncı: Duzce University

Ana Başlıklar: Clinical Sciences

Dergi: Duzce Medical Journal Vol.25 Issue 2, pp.185-188

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001289189

pISSN: 1307-671X

Biomarker

Endometrial cancer

Endometrial hyperplasiaBiyobelirteç

Endometriyal Kanser

Endometriyal hiperplazi

Sayı

Yazarlar:

Caner Kose | Büşra Körpe | Vakkas Korkmaz | Yaprak Ustun

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences

Dergi:

Duzce Medical Journal Vol.25 Issue 2, pp.185-188

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289189

pISSN:

1307-671X