Investigation of photon ınteraction parameters of some premedication drugs

Halime Erzen Yıldız

Makale detayları

Investigation of photon ınteraction parameters of some premedication drugs

Yazarlar:

Halime Erzen Yıldız

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Radiophysics

Dergi:

Journal of Scientific Reports-A Issue 061, pp.88-99

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001353076

pISSN:

2687-6167

Anahtar kelimeler:

Özet:

 Premedication, also known as the preparation phase, is the administration of drugs to patients before chemotherapy to reduce the side effects of chemotherapy in oncology patients. Metoclopramide, ranitidine and pheniramine are some of these drugs. Metoclopramide is a routine antiemetic for nausea and vomiting caused by antineoplastic drugs, especially cisplatin, due to its effect on the medulla chemoreceptor trigger zone. Ranitidine, which belongs to the histamine receptor 2 H2 antagonist family, is a widely used drug clinically to control gastrointestinal symptoms. Pheniramine is an antagonist against allergic symptoms caused by inappropriate histamine release to reduce edema, pruritus and redness. Sometimes patients are given premedication drugs before radiological examination. In this study, photon interaction parameters of some premedication drugs metoclopramide, ranitidine hydrochloride, and pheniramine were investigated, namely mass attenuation coefficient µρ, effective atomic number Zeff, electron density Nel, exposure and absorption accumulation factors EBF and EABF. Maximum µρ values for all drugs were found at low gamma energies. It was found that ranitidine hydrochloride has the highest Zeff values in almost the entire energy range due to the presence of S and Cl. In addition, ranitidine hydrochloride showed the lowest EBF and EABF values, indicating that the material does not emit much radiation to the environment.

 Premedication, also known as the preparation phase, is the administration of drugs to patients before chemotherapy to reduce the side effects of chemotherapy in oncology patients. Metoclopramide, ranitidine and pheniramine are some of these drugs. Metoclopramide is a routine antiemetic for nausea and vomiting caused by antineoplastic drugs, especially cisplatin, due to its effect on the medulla chemoreceptor trigger zone. Ranitidine, which belongs to the histamine receptor 2 H2 antagonist family, is a widely used drug clinically to control gastrointestinal symptoms. Pheniramine is an antagonist against allergic symptoms caused by inappropriate histamine release to reduce edema, pruritus and redness. Sometimes patients are given premedication drugs before radiological examination. In this study, photon interaction parameters of some premedication drugs metoclopramide, ranitidine hydrochloride, and pheniramine were investigated, namely mass attenuation coefficient µρ, effective atomic number Zeff, electron density Nel, exposure and absorption accumulation factors EBF and EABF. Maximum µρ values for all drugs were found at low gamma energies. It was found that ranitidine hydrochloride has the highest Zeff values in almost the entire energy range due to the presence of S and Cl. In addition, ranitidine hydrochloride showed the lowest EBF and EABF values, indicating that the material does not emit much radiation to the environment.

 Premedication, also known as the preparation phase, is the administration of drugs to patients before chemotherapy to reduce the side effects of chemotherapy in oncology patients. Metoclopramide, ranitidine and pheniramine are some of these drugs. Metoclopramide is a routine antiemetic for nausea and vomiting caused by antineoplastic drugs, especially cisplatin, due to its effect on the medulla chemoreceptor trigger zone. Ranitidine, which belongs to the histamine receptor 2 H2 antagonist family, is a widely used drug clinically to control gastrointestinal symptoms. Pheniramine is an antagonist against allergic symptoms caused by inappropriate histamine release to reduce edema, pruritus and redness. Sometimes patients are given premedication drugs before radiological examination. In this study, photon interaction parameters of some premedication drugs metoclopramide, ranitidine hydrochloride, and pheniramine were investigated, namely mass attenuation coefficient µρ, effective atomic number Zeff, electron density Nel, exposure and absorption accumulation factors EBF and EABF. Maximum µρ values for all drugs were found at low gamma energies. It was found that ranitidine hydrochloride has the highest Zeff values in almost the entire energy range due to the presence of S and Cl. In addition, ranitidine hydrochloride showed the lowest EBF and EABF values, indicating that the material does not emit much radiation to the environment.

 Premedication, also known as the preparation phase, is the administration of drugs to patients before chemotherapy to reduce the side effects of chemotherapy in oncology patients. Metoclopramide, ranitidine and pheniramine are some of these drugs. Metoclopramide is a routine antiemetic for nausea and vomiting caused by antineoplastic drugs, especially cisplatin, due to its effect on the medulla chemoreceptor trigger zone. Ranitidine, which belongs to the histamine receptor 2 H2 antagonist family, is a widely used drug clinically to control gastrointestinal symptoms. Pheniramine is an antagonist against allergic symptoms caused by inappropriate histamine release to reduce edema, pruritus and redness. Sometimes patients are given premedication drugs before radiological examination. In this study, photon interaction parameters of some premedication drugs metoclopramide, ranitidine hydrochloride, and pheniramine were investigated, namely mass attenuation coefficient µρ, effective atomic number Zeff, electron density Nel, exposure and absorption accumulation factors EBF and EABF. Maximum µρ values for all drugs were found at low gamma energies. It was found that ranitidine hydrochloride has the highest Zeff values in almost the entire energy range due to the presence of S and Cl. In addition, ranitidine hydrochloride showed the lowest EBF and EABF values, indicating that the material does not emit much radiation to the environment.

Makale detayları

Investigation of photon ınteraction parameters of some premedication drugs

Yazarlar:

Halime Erzen Yıldız

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Radiophysics

Dergi:

Journal of Scientific Reports-A Issue 061, pp.88-99

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001353076

pISSN:

2687-6167

: Buildup factors

effective atomic number

mass attenuation coefficients

premedication drugs

Sayı

Makale detayları

Investigation of photon ınteraction parameters of some premedication drugs

Yazarlar: Halime Erzen Yıldız

Yayıncı: Kütahya Dumlupinar University

Ana Başlıklar: Radiophysics

Dergi: Journal of Scientific Reports-A Issue 061, pp.88-99

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001353076

pISSN: 2687-6167

: Buildup factors

effective atomic number

mass attenuation coefficients

premedication drugs

Sayı

Yazarlar:

Halime Erzen Yıldız

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Radiophysics

Dergi:

Journal of Scientific Reports-A Issue 061, pp.88-99

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001353076

pISSN:

2687-6167