Sexually transmitted infections (STIs)/HIV linked to human papillomavirus (HPV) in precancerous lesions in Cameroonian women

Elisee Libert Embolo Enyegue

Makale detayları

Sexually transmitted infections (STIs)/HIV linked to human papillomavirus (HPV) in precancerous lesions in Cameroonian women

Yazarlar:

Elisee Libert Embolo Enyegue

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Cancer Cell Biology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 3, pp.530-536

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325914

pISSN:

1309-4483

Anahtar kelimeler:

Özet:

 Cervical precancerous lesions signify cellular changes in the cervix linked to an escalated risk of cancer. These lesions often evolve towards malignancy influenced by various factors, including sexually transmitted infections STIs, irrespective of human papillomavirus HPV presence. STIs represent a substantial global public health concern, affecting both sexes, with over 30 pathogens, comprising bacteria, viruses, and parasites, capable of causing STIs. The clinical presentation of these pathogens varies significantly. This study aimed to delineate the microbial profile within HPV-containing precancerous lesions. A prospective cross-sectional descriptive study was conducted in Cameroons central region, particularly in the Endom district. Among 343 patients screened, 225 women were enrolled based on positive HPV cervical smear results. Cervical cell lesions were analyzed using the Papanicolaou technique, while parasitological and microbiological methods were utilized to identify other microbes. HPV genotypes were determined via multiplex PCR. The study revealed 65 HIV-positive and HPV-positive individuals 18.96; 40 HIV-negative and HPV-positive individuals 11.65; 25 HIV-positive and HPV-negative individuals 7.29; and 213 HIV-negative and HPV-negative individuals 62.10. Various cervical lesions were identified, including Low-grade Lesions LSILs 21 and High-grade lesions HSILs 16. Trichomonas vaginalis TV 51, Candida albicans CA 28, Herpes simplex HS 2, Gardnerella vaginalis GV 17, Aspergillus A 2, and HIV were the primary infectious agents identified in these precancerous lesions, with significant distribution P0.005, suggesting their role as risk factors for precancerous lesions OR13.89, 95 CI 6.87-21.60. Multiple HPV genotypes were characterized in the same precancerous lesions, with approximately 25 85 of women harboring either Low_Risk LR 6, 11 or High_Risk HR 16, 18, 45, 58 HPV genotypes P0.001. Coinfections such as HPVTVCA and HPVHIVTV were prevalent, indicating their potential as associated risk factors for precancerous lesions. Coinfections with other microbes, typically associated with cervicitis, appear to facilitate HPV infection. These findings contribute to understanding the microbial landscape of cervical samples and underscore the importance of integrated care approaches for HIV-positive individuals with HPV-related lesions.

 Cervical precancerous lesions signify cellular changes in the cervix linked to an escalated risk of cancer. These lesions often evolve towards malignancy influenced by various factors, including sexually transmitted infections STIs, irrespective of human papillomavirus HPV presence. STIs represent a substantial global public health concern, affecting both sexes, with over 30 pathogens, comprising bacteria, viruses, and parasites, capable of causing STIs. The clinical presentation of these pathogens varies significantly. This study aimed to delineate the microbial profile within HPV-containing precancerous lesions. A prospective cross-sectional descriptive study was conducted in Cameroons central region, particularly in the Endom district. Among 343 patients screened, 225 women were enrolled based on positive HPV cervical smear results. Cervical cell lesions were analyzed using the Papanicolaou technique, while parasitological and microbiological methods were utilized to identify other microbes. HPV genotypes were determined via multiplex PCR. The study revealed 65 HIV-positive and HPV-positive individuals 18.96; 40 HIV-negative and HPV-positive individuals 11.65; 25 HIV-positive and HPV-negative individuals 7.29; and 213 HIV-negative and HPV-negative individuals 62.10. Various cervical lesions were identified, including Low-grade Lesions LSILs 21 and High-grade lesions HSILs 16. Trichomonas vaginalis TV 51, Candida albicans CA 28, Herpes simplex HS 2, Gardnerella vaginalis GV 17, Aspergillus A 2, and HIV were the primary infectious agents identified in these precancerous lesions, with significant distribution P0.005, suggesting their role as risk factors for precancerous lesions OR13.89, 95 CI 6.87-21.60. Multiple HPV genotypes were characterized in the same precancerous lesions, with approximately 25 85 of women harboring either Low_Risk LR 6, 11 or High_Risk HR 16, 18, 45, 58 HPV genotypes P0.001. Coinfections such as HPVTVCA and HPVHIVTV were prevalent, indicating their potential as associated risk factors for precancerous lesions. Coinfections with other microbes, typically associated with cervicitis, appear to facilitate HPV infection. These findings contribute to understanding the microbial landscape of cervical samples and underscore the importance of integrated care approaches for HIV-positive individuals with HPV-related lesions.

 Cervical precancerous lesions signify cellular changes in the cervix linked to an escalated risk of cancer. These lesions often evolve towards malignancy influenced by various factors, including sexually transmitted infections STIs, irrespective of human papillomavirus HPV presence. STIs represent a substantial global public health concern, affecting both sexes, with over 30 pathogens, comprising bacteria, viruses, and parasites, capable of causing STIs. The clinical presentation of these pathogens varies significantly. This study aimed to delineate the microbial profile within HPV-containing precancerous lesions. A prospective cross-sectional descriptive study was conducted in Cameroons central region, particularly in the Endom district. Among 343 patients screened, 225 women were enrolled based on positive HPV cervical smear results. Cervical cell lesions were analyzed using the Papanicolaou technique, while parasitological and microbiological methods were utilized to identify other microbes. HPV genotypes were determined via multiplex PCR. The study revealed 65 HIV-positive and HPV-positive individuals 18.96; 40 HIV-negative and HPV-positive individuals 11.65; 25 HIV-positive and HPV-negative individuals 7.29; and 213 HIV-negative and HPV-negative individuals 62.10. Various cervical lesions were identified, including Low-grade Lesions LSILs 21 and High-grade lesions HSILs 16. Trichomonas vaginalis TV 51, Candida albicans CA 28, Herpes simplex HS 2, Gardnerella vaginalis GV 17, Aspergillus A 2, and HIV were the primary infectious agents identified in these precancerous lesions, with significant distribution P0.005, suggesting their role as risk factors for precancerous lesions OR13.89, 95 CI 6.87-21.60. Multiple HPV genotypes were characterized in the same precancerous lesions, with approximately 25 85 of women harboring either Low_Risk LR 6, 11 or High_Risk HR 16, 18, 45, 58 HPV genotypes P0.001. Coinfections such as HPVTVCA and HPVHIVTV were prevalent, indicating their potential as associated risk factors for precancerous lesions. Coinfections with other microbes, typically associated with cervicitis, appear to facilitate HPV infection. These findings contribute to understanding the microbial landscape of cervical samples and underscore the importance of integrated care approaches for HIV-positive individuals with HPV-related lesions.

 Cervical precancerous lesions signify cellular changes in the cervix linked to an escalated risk of cancer. These lesions often evolve towards malignancy influenced by various factors, including sexually transmitted infections STIs, irrespective of human papillomavirus HPV presence. STIs represent a substantial global public health concern, affecting both sexes, with over 30 pathogens, comprising bacteria, viruses, and parasites, capable of causing STIs. The clinical presentation of these pathogens varies significantly. This study aimed to delineate the microbial profile within HPV-containing precancerous lesions. A prospective cross-sectional descriptive study was conducted in Cameroons central region, particularly in the Endom district. Among 343 patients screened, 225 women were enrolled based on positive HPV cervical smear results. Cervical cell lesions were analyzed using the Papanicolaou technique, while parasitological and microbiological methods were utilized to identify other microbes. HPV genotypes were determined via multiplex PCR. The study revealed 65 HIV-positive and HPV-positive individuals 18.96; 40 HIV-negative and HPV-positive individuals 11.65; 25 HIV-positive and HPV-negative individuals 7.29; and 213 HIV-negative and HPV-negative individuals 62.10. Various cervical lesions were identified, including Low-grade Lesions LSILs 21 and High-grade lesions HSILs 16. Trichomonas vaginalis TV 51, Candida albicans CA 28, Herpes simplex HS 2, Gardnerella vaginalis GV 17, Aspergillus A 2, and HIV were the primary infectious agents identified in these precancerous lesions, with significant distribution P0.005, suggesting their role as risk factors for precancerous lesions OR13.89, 95 CI 6.87-21.60. Multiple HPV genotypes were characterized in the same precancerous lesions, with approximately 25 85 of women harboring either Low_Risk LR 6, 11 or High_Risk HR 16, 18, 45, 58 HPV genotypes P0.001. Coinfections such as HPVTVCA and HPVHIVTV were prevalent, indicating their potential as associated risk factors for precancerous lesions. Coinfections with other microbes, typically associated with cervicitis, appear to facilitate HPV infection. These findings contribute to understanding the microbial landscape of cervical samples and underscore the importance of integrated care approaches for HIV-positive individuals with HPV-related lesions.

Makale detayları

Sexually transmitted infections (STIs)/HIV linked to human papillomavirus (HPV) in precancerous lesions in Cameroonian women

Yazarlar:

Elisee Libert Embolo Enyegue

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Cancer Cell Biology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 3, pp.530-536

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325914

pISSN:

1309-4483

Precancerous lesions

HPV

Coinfections

Cervical cytology

Microbial composition

Sayı

Makale detayları

Sexually transmitted infections (STIs)/HIV linked to human papillomavirus (HPV) in precancerous lesions in Cameroonian women

Yazarlar: Elisee Libert Embolo Enyegue

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Cancer Cell Biology

Dergi: Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 3, pp.530-536

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001325914

pISSN: 1309-4483

Precancerous lesions

HPV

Coinfections

Cervical cytology

Microbial composition

Sayı

Yazarlar:

Elisee Libert Embolo Enyegue

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Cancer Cell Biology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 3, pp.530-536

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325914

pISSN:

1309-4483