The effect of alkali burn on corneal glutathione peroxidase activities in rabbits

İlknur Akyol SALMAN; Ahmet KIZILTUNÇ; Orhan BAYKAL

Makale detayları

The effect of alkali burn on corneal glutathione peroxidase activities in rabbits

Yazarlar:

İlknur Akyol SALMAN | Ahmet KIZILTUNÇ | Orhan BAYKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 3, pp.483-486

Belge Tipi:

Makale

Yayın Tarihi:

2/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754713

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Glutathione peroxidase (GPx) is an important corneal defense enzyme for protecting against hydrogen peroxides and lipid peroxides. In the present study, corneal GPx activities after alkali burn of the cornea were evaluated in rabbits.  Materials and methods: Corneal alkali burn was created in the right eye of 10 rabbits by applying a 6 mm round filter paper soaked in 1 N NaOH onto the central cornea for 60 s. The right eyes of 10 healthy rabbits served as controls. The corneal GPx activities were determined by the method of Paglia and Valentina, 10 days after the burn.   Results: GPx activities were reduced significantly in alkali burned corneas compared to the normal controls (P < 0.05).  Conclusion: The data suggest that decreased GPx activities predispose the cornea to injury from reactive oxygen radicals, besides the initial chemical damage of alkali burn.

 

Glutathione peroxidase (GPx) is an important corneal defense enzyme for protecting against hydrogen peroxides and lipid peroxides. In the present study, corneal GPx activities after alkali burn of the cornea were evaluated in rabbits.  Materials and methods: Corneal alkali burn was created in the right eye of 10 rabbits by applying a 6 mm round filter paper soaked in 1 N NaOH onto the central cornea for 60 s. The right eyes of 10 healthy rabbits served as controls. The corneal GPx activities were determined by the method of Paglia and Valentina, 10 days after the burn.   Results: GPx activities were reduced significantly in alkali burned corneas compared to the normal controls (P < 0.05).  Conclusion: The data suggest that decreased GPx activities predispose the cornea to injury from reactive oxygen radicals, besides the initial chemical damage of alkali burn.

Makale detayları

The effect of alkali burn on corneal glutathione peroxidase activities in rabbits

Yazarlar:

İlknur Akyol SALMAN | Ahmet KIZILTUNÇ | Orhan BAYKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 3, pp.483-486

Belge Tipi:

Makale

Yayın Tarihi:

2/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754713

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Corneal alkali burn

free oxygen radicals

glutathione peroxidase

hydrogen peroxide

reactive oxygen species

Sayı

Makale detayları

The effect of alkali burn on corneal glutathione peroxidase activities in rabbits

Yazarlar: İlknur Akyol SALMAN | Ahmet KIZILTUNÇ | Orhan BAYKAL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2011 Vol.41 Issue 3, pp.483-486

Belge Tipi: Makale

Yayın Tarihi: 2/2011

Belge Dili: Türkçe

Document ID (Org No.): 2000754713

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Corneal alkali burn

free oxygen radicals

glutathione peroxidase

hydrogen peroxide

reactive oxygen species

Sayı

Yazarlar:

İlknur Akyol SALMAN | Ahmet KIZILTUNÇ | Orhan BAYKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 3, pp.483-486

Belge Tipi:

Makale

Yayın Tarihi:

2/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754713

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144