The Relationship Between Zinc Level and Pathological Response in Rectum Cancer Patients Receiving Total Neoadjuvant Therapy

Efe Cem Erdat

Makale detayları

The Relationship Between Zinc Level and Pathological Response in Rectum Cancer Patients Receiving Total Neoadjuvant Therapy

Yazarlar:

Efe Cem Erdat

Yayıncı:

Ankara University

Ana Başlıklar:

Clinical Oncology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.77 Issue 3, pp.253-257

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001349163

pISSN:

0365-8104

Anahtar kelimeler:

Özet:

 Objectives: Total neoadjuvant therapy TNT is used as the gold standard in rectal cancers. It is known that zinc has an effect on the cell cycle, intracellular pathways and cell proliferation. Our study was planned to investigate the relationship between zinc level and response in rectal cancer patients receiving TNT. Materials and Methods: Information of 29 patients with rectal cancer who received TNT treatment at Ankara University Faculty of Medicine, Department of Medical Oncology was collected retrospectively and its relationship with treatment response was evaluated. Statistical analysis was performed using classical methods and Bayesian analysis. Results: A total of 29 patients, 18 males and 11 females, were included in the study. The median age was 66 years, and histologically, 26 of the patients were found to have adenocarcinoma histology. As neoadjuvant treatment, 22 patients received short-arm radiotherapy and chemotherapy, and 7 patients received long-arm radiotherapy and chemotherapy. The median zinc level in patients with a complete response to treatment was 89 μgdL, and in those with a partial response, the median zinc level was 77 μgdL p0.07. In Bayesian analysis, the result was evaluated moderately. Conclusion: Although a statistically significant difference was observed indicating that TNT response in rectal cancer may increase with high zinc levels, the findings are moderate according to Bayesian analysis.

 Objectives: Total neoadjuvant therapy TNT is used as the gold standard in rectal cancers. It is known that zinc has an effect on the cell cycle, intracellular pathways and cell proliferation. Our study was planned to investigate the relationship between zinc level and response in rectal cancer patients receiving TNT. Materials and Methods: Information of 29 patients with rectal cancer who received TNT treatment at Ankara University Faculty of Medicine, Department of Medical Oncology was collected retrospectively and its relationship with treatment response was evaluated. Statistical analysis was performed using classical methods and Bayesian analysis. Results: A total of 29 patients, 18 males and 11 females, were included in the study. The median age was 66 years, and histologically, 26 of the patients were found to have adenocarcinoma histology. As neoadjuvant treatment, 22 patients received short-arm radiotherapy and chemotherapy, and 7 patients received long-arm radiotherapy and chemotherapy. The median zinc level in patients with a complete response to treatment was 89 μgdL, and in those with a partial response, the median zinc level was 77 μgdL p0.07. In Bayesian analysis, the result was evaluated moderately. Conclusion: Although a statistically significant difference was observed indicating that TNT response in rectal cancer may increase with high zinc levels, the findings are moderate according to Bayesian analysis.

 Objectives: Total neoadjuvant therapy TNT is used as the gold standard in rectal cancers. It is known that zinc has an effect on the cell cycle, intracellular pathways and cell proliferation. Our study was planned to investigate the relationship between zinc level and response in rectal cancer patients receiving TNT. Materials and Methods: Information of 29 patients with rectal cancer who received TNT treatment at Ankara University Faculty of Medicine, Department of Medical Oncology was collected retrospectively and its relationship with treatment response was evaluated. Statistical analysis was performed using classical methods and Bayesian analysis. Results: A total of 29 patients, 18 males and 11 females, were included in the study. The median age was 66 years, and histologically, 26 of the patients were found to have adenocarcinoma histology. As neoadjuvant treatment, 22 patients received short-arm radiotherapy and chemotherapy, and 7 patients received long-arm radiotherapy and chemotherapy. The median zinc level in patients with a complete response to treatment was 89 μgdL, and in those with a partial response, the median zinc level was 77 μgdL p0.07. In Bayesian analysis, the result was evaluated moderately. Conclusion: Although a statistically significant difference was observed indicating that TNT response in rectal cancer may increase with high zinc levels, the findings are moderate according to Bayesian analysis.

 Objectives: Total neoadjuvant therapy TNT is used as the gold standard in rectal cancers. It is known that zinc has an effect on the cell cycle, intracellular pathways and cell proliferation. Our study was planned to investigate the relationship between zinc level and response in rectal cancer patients receiving TNT. Materials and Methods: Information of 29 patients with rectal cancer who received TNT treatment at Ankara University Faculty of Medicine, Department of Medical Oncology was collected retrospectively and its relationship with treatment response was evaluated. Statistical analysis was performed using classical methods and Bayesian analysis. Results: A total of 29 patients, 18 males and 11 females, were included in the study. The median age was 66 years, and histologically, 26 of the patients were found to have adenocarcinoma histology. As neoadjuvant treatment, 22 patients received short-arm radiotherapy and chemotherapy, and 7 patients received long-arm radiotherapy and chemotherapy. The median zinc level in patients with a complete response to treatment was 89 μgdL, and in those with a partial response, the median zinc level was 77 μgdL p0.07. In Bayesian analysis, the result was evaluated moderately. Conclusion: Although a statistically significant difference was observed indicating that TNT response in rectal cancer may increase with high zinc levels, the findings are moderate according to Bayesian analysis.

Makale detayları

The Relationship Between Zinc Level and Pathological Response in Rectum Cancer Patients Receiving Total Neoadjuvant Therapy

Yazarlar:

Efe Cem Erdat

Yayıncı:

Ankara University

Ana Başlıklar:

Clinical Oncology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.77 Issue 3, pp.253-257

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001349163

pISSN:

0365-8104

Rectum cancer

neoadjuvant therapy

treatment response

zinc

Sayı

Makale detayları

The Relationship Between Zinc Level and Pathological Response in Rectum Cancer Patients Receiving Total Neoadjuvant Therapy

Yazarlar: Efe Cem Erdat

Yayıncı: Ankara University

Ana Başlıklar: Clinical Oncology

Dergi: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.77 Issue 3, pp.253-257

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001349163

pISSN: 0365-8104

Rectum cancer

neoadjuvant therapy

treatment response

zinc

Sayı

Yazarlar:

Efe Cem Erdat

Yayıncı:

Ankara University

Ana Başlıklar:

Clinical Oncology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.77 Issue 3, pp.253-257

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001349163

pISSN:

0365-8104