Synthesis, characterization and antimicrobial evaluation of new 2-(2-thienylcarbonyl)hydrazono-3-alkyl/aryl-4-thiazolidinone and 2-aryl-3-(2-thienylcarbonyl)amino-4-thiazolidinone derivatives

Efe Doğukan Dincel; Dilek Şatana; Nuray Ulusoy Güzeldemirci

Makale detayları

Synthesis, characterization and antimicrobial evaluation of new 2-(2-thienylcarbonyl)hydrazono-3-alkyl/aryl-4-thiazolidinone and 2-aryl-3-(2-thienylcarbonyl)amino-4-thiazolidinone derivatives

Yazarlar:

Efe Doğukan Dincel | Dilek Şatana | Nuray Ulusoy Güzeldemirci

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 3, pp.641-654

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346861

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 A series of novel 2-2-thienylcarbonylhydrazono-3-alkylaryl-4-thiazolidinone 2a-f, 2-2-thienyl-5-4-bromophenylamino-1,3,4-oxadiazole 3, 2-aryl-3-2-thienylcarbonylamino-4-thiazolidinone 5a-h and 2-aryl-3-2-thienylcarbonylamino-5-methyl-4-thiazolidinone 6a-h were designed and synthesized. The structural elucidations of the novel compounds were performed by IR, 1H-NMR, mass and elemental analysis. The compounds were evaluated for their antimycobacterial and antifungal activities. According to the biological activity studies activities of the compounds, 2f MIC: 12.5 gml, 76 inhibition, 3 MIC: 12.5 gml, 43 inhibition, and 5c MIC: 12.5 gml, 38 inhibition, displayed antimycobacterial activity. 2b MIC: 25 gml displayed antifungal activity against T. rubrum. Besides, x-ray crystallography studies were performed to illuminate the structure of 2e. Consequently, the obtained results relvealed that 2f, 3 and 5c present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.

 A series of novel 2-2-thienylcarbonylhydrazono-3-alkylaryl-4-thiazolidinone 2a-f, 2-2-thienyl-5-4-bromophenylamino-1,3,4-oxadiazole 3, 2-aryl-3-2-thienylcarbonylamino-4-thiazolidinone 5a-h and 2-aryl-3-2-thienylcarbonylamino-5-methyl-4-thiazolidinone 6a-h were designed and synthesized. The structural elucidations of the novel compounds were performed by IR, 1H-NMR, mass and elemental analysis. The compounds were evaluated for their antimycobacterial and antifungal activities. According to the biological activity studies activities of the compounds, 2f MIC: 12.5 gml, 76 inhibition, 3 MIC: 12.5 gml, 43 inhibition, and 5c MIC: 12.5 gml, 38 inhibition, displayed antimycobacterial activity. 2b MIC: 25 gml displayed antifungal activity against T. rubrum. Besides, x-ray crystallography studies were performed to illuminate the structure of 2e. Consequently, the obtained results relvealed that 2f, 3 and 5c present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.

 A series of novel 2-2-thienylcarbonylhydrazono-3-alkylaryl-4-thiazolidinone 2a-f, 2-2-thienyl-5-4-bromophenylamino-1,3,4-oxadiazole 3, 2-aryl-3-2-thienylcarbonylamino-4-thiazolidinone 5a-h and 2-aryl-3-2-thienylcarbonylamino-5-methyl-4-thiazolidinone 6a-h were designed and synthesized. The structural elucidations of the novel compounds were performed by IR, 1H-NMR, mass and elemental analysis. The compounds were evaluated for their antimycobacterial and antifungal activities. According to the biological activity studies activities of the compounds, 2f MIC: 12.5 gml, 76 inhibition, 3 MIC: 12.5 gml, 43 inhibition, and 5c MIC: 12.5 gml, 38 inhibition, displayed antimycobacterial activity. 2b MIC: 25 gml displayed antifungal activity against T. rubrum. Besides, x-ray crystallography studies were performed to illuminate the structure of 2e. Consequently, the obtained results relvealed that 2f, 3 and 5c present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.

 A series of novel 2-2-thienylcarbonylhydrazono-3-alkylaryl-4-thiazolidinone 2a-f, 2-2-thienyl-5-4-bromophenylamino-1,3,4-oxadiazole 3, 2-aryl-3-2-thienylcarbonylamino-4-thiazolidinone 5a-h and 2-aryl-3-2-thienylcarbonylamino-5-methyl-4-thiazolidinone 6a-h were designed and synthesized. The structural elucidations of the novel compounds were performed by IR, 1H-NMR, mass and elemental analysis. The compounds were evaluated for their antimycobacterial and antifungal activities. According to the biological activity studies activities of the compounds, 2f MIC: 12.5 gml, 76 inhibition, 3 MIC: 12.5 gml, 43 inhibition, and 5c MIC: 12.5 gml, 38 inhibition, displayed antimycobacterial activity. 2b MIC: 25 gml displayed antifungal activity against T. rubrum. Besides, x-ray crystallography studies were performed to illuminate the structure of 2e. Consequently, the obtained results relvealed that 2f, 3 and 5c present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.

Makale detayları

Synthesis, characterization and antimicrobial evaluation of new 2-(2-thienylcarbonyl)hydrazono-3-alkyl/aryl-4-thiazolidinone and 2-aryl-3-(2-thienylcarbonyl)amino-4-thiazolidinone derivatives

Yazarlar:

Efe Doğukan Dincel | Dilek Şatana | Nuray Ulusoy Güzeldemirci

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 3, pp.641-654

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346861

pISSN:

2630-6344

4-Thiazolidinones

oxadiazole

crystal structure

antimycobacterial activity

antifungal activity

Sayı

Makale detayları

Synthesis, characterization and antimicrobial evaluation of new 2-(2-thienylcarbonyl)hydrazono-3-alkyl/aryl-4-thiazolidinone and 2-aryl-3-(2-thienylcarbonyl)amino-4-thiazolidinone derivatives

Yazarlar: Efe Doğukan Dincel | Dilek Şatana | Nuray Ulusoy Güzeldemirci

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Sciences

Dergi: Journal of Research in Pharmacy Vol.26 Issue 3, pp.641-654

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346861

pISSN: 2630-6344

4-Thiazolidinones

oxadiazole

crystal structure

antimycobacterial activity

antifungal activity

Sayı

Yazarlar:

Efe Doğukan Dincel | Dilek Şatana | Nuray Ulusoy Güzeldemirci

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 3, pp.641-654

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346861

pISSN:

2630-6344