COMPARISON OF THE EFFECTS OF CLINICOPATHOLOGICAL AND RADIOLOGICAL FINDINGS ON SURVIVAL IN WOMEN YOUNGER THAN 40 YEARS AND OLDER THAN 55 YEARS OF AGE WITH BREAST CANCER

Buket Altun Özdemir; Servet Kocaöz; Bülent Çomçalı; Mustafa Ömer Yazıcıoğlu; Fırat Canlıkarakaya; Cengiz Ceylan; Birol Korukluoğlu

Makale detayları

COMPARISON OF THE EFFECTS OF CLINICOPATHOLOGICAL AND RADIOLOGICAL FINDINGS ON SURVIVAL IN WOMEN YOUNGER THAN 40 YEARS AND OLDER THAN 55 YEARS OF AGE WITH BREAST CANCER

Yazarlar:

Buket Altun Özdemir | Servet Kocaöz | Bülent Çomçalı | Mustafa Ömer Yazıcıoğlu | Fırat Canlıkarakaya | Cengiz Ceylan | Birol Korukluoğlu

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Clinical Sciences

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.37-45

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285079

pISSN:

1300-7416

Anahtar kelimeler:

Özet:

 Objective Tumors of women with breast cancer show clinical and biological differences depending on the hormonal changes that develop with age. Therefore, in this study, we compared the radiologic, and clinicopathological features of breast cancer patients  40 age and 55 age. Material and Method The files of a total of 759 patients, including 92 patients under 40 aged, and 322 patients 55 aged and over who were operated on for breast cancer over a 10-year period in three centres were retrospectively reviewed and Estrojen Reseptor ER, Progesteron Reseptor PR, Human epidermal growth factor receptor 2 HER2, Lymphovascular invasion LVI status, presence of axillary lymph node metastasis ALNM, multifocality, presence of Ductal Carsinoma İnsitu DCIS or Lobular Carsinoma İnsitu LCIS, tumor size, tumor histopathological type, grade, and score were recorded. Results In patients under the age of 40, the tumor is less localized in the upper-inner and lower-inner quadrants of the breast, multifocality is more common, most of them have dense breast structure, the histological grade of the tumor is higher, LVI and LNM are more common. It was found that they had ER receptor positivity and higher Ki-67 proliferation index p0.001, p0.001, p0.001, p0.001, p0.021, p0.039, p0.001 and p0.001, respectively. It was observed that the multifocality and density of breast tissue were lower in tumors in patients under 55 years of age p  0.002, p 0.001, respectively. Luminal B and TN were more common among molecular subtypes in patients under 40 years of age, while luminal A subtype was more common in patients over 55 years of age p0.001, p0.001, respectively. Conclusion Clinicopathological differences between 40 aged, and 55 aged and over patients were confirmed. Adverse prognostic factors for breast cancer at the age of under 40 patients were revealed.

 Objective Tumors of women with breast cancer show clinical and biological differences depending on the hormonal changes that develop with age. Therefore, in this study, we compared the radiologic, and clinicopathological features of breast cancer patients  40 age and 55 age. Material and Method The files of a total of 759 patients, including 92 patients under 40 aged, and 322 patients 55 aged and over who were operated on for breast cancer over a 10-year period in three centres were retrospectively reviewed and Estrojen Reseptor ER, Progesteron Reseptor PR, Human epidermal growth factor receptor 2 HER2, Lymphovascular invasion LVI status, presence of axillary lymph node metastasis ALNM, multifocality, presence of Ductal Carsinoma İnsitu DCIS or Lobular Carsinoma İnsitu LCIS, tumor size, tumor histopathological type, grade, and score were recorded. Results In patients under the age of 40, the tumor is less localized in the upper-inner and lower-inner quadrants of the breast, multifocality is more common, most of them have dense breast structure, the histological grade of the tumor is higher, LVI and LNM are more common. It was found that they had ER receptor positivity and higher Ki-67 proliferation index p0.001, p0.001, p0.001, p0.001, p0.021, p0.039, p0.001 and p0.001, respectively. It was observed that the multifocality and density of breast tissue were lower in tumors in patients under 55 years of age p  0.002, p 0.001, respectively. Luminal B and TN were more common among molecular subtypes in patients under 40 years of age, while luminal A subtype was more common in patients over 55 years of age p0.001, p0.001, respectively. Conclusion Clinicopathological differences between 40 aged, and 55 aged and over patients were confirmed. Adverse prognostic factors for breast cancer at the age of under 40 patients were revealed.

 Objective Tumors of women with breast cancer show clinical and biological differences depending on the hormonal changes that develop with age. Therefore, in this study, we compared the radiologic, and clinicopathological features of breast cancer patients  40 age and 55 age. Material and Method The files of a total of 759 patients, including 92 patients under 40 aged, and 322 patients 55 aged and over who were operated on for breast cancer over a 10-year period in three centres were retrospectively reviewed and Estrojen Reseptor ER, Progesteron Reseptor PR, Human epidermal growth factor receptor 2 HER2, Lymphovascular invasion LVI status, presence of axillary lymph node metastasis ALNM, multifocality, presence of Ductal Carsinoma İnsitu DCIS or Lobular Carsinoma İnsitu LCIS, tumor size, tumor histopathological type, grade, and score were recorded. Results In patients under the age of 40, the tumor is less localized in the upper-inner and lower-inner quadrants of the breast, multifocality is more common, most of them have dense breast structure, the histological grade of the tumor is higher, LVI and LNM are more common. It was found that they had ER receptor positivity and higher Ki-67 proliferation index p0.001, p0.001, p0.001, p0.001, p0.021, p0.039, p0.001 and p0.001, respectively. It was observed that the multifocality and density of breast tissue were lower in tumors in patients under 55 years of age p  0.002, p 0.001, respectively. Luminal B and TN were more common among molecular subtypes in patients under 40 years of age, while luminal A subtype was more common in patients over 55 years of age p0.001, p0.001, respectively. Conclusion Clinicopathological differences between 40 aged, and 55 aged and over patients were confirmed. Adverse prognostic factors for breast cancer at the age of under 40 patients were revealed.

 Amaç Meme kanserli kadınların tümörleri, yaşla birlikte gelişen hormonal değişikliklere bağlı olarak klinik ve biyolojik farklılıklar göstermektedir. Bu nedenle bu çalışmada meme kanserli hastaların 40 yaş ve 55 yaşlarının radyolojik ve klinikopatolojik özelliklerini karşılaştırdık. Gereç ve Yöntem 10 yıllık dönemde üç merkezde meme kanseri nedeniyle opere edilen 40 yaş altı 92 hasta ve 55 yaş ve üzeri 322 hasta olmak üzere toplam 759 hastanın dosyaları geriye dönük olarak incelendi ve Östrojen Reseptör ER, Progesteron Reseptör PR, İnsan Epidermal Büyüme Faktörü 2 HER2 ,Lenfovaskuler İnvazyon  LVI  durumu, Aksiller Lenf Nodu Metastazı ALNM varlığı, multifokalite, Duktal Karsinoma İnsitu DCIS veya Lobuler Karsinoma İnsitu LCIS varlığı, tümör boyutu, tümör histopatolojik tipi, tümör derecesi ve skoru kaydedildi. Bulgular 40 yaşın altındaki hastalarda tümörün memenin üst-iç ve alt-iç kadranlarında daha az yerleştiği, multifokalitenin ise daha sık görüldüğü, büyük bir çoğunluğunun dens meme yapısına sahip olduğu, tümörün histolojik derecesinin yüksek olduğu, LVI ve LNMnin daha sık görüldüğü, daha düşük ER reseptör pozitifliği ve daha yüksek Ki-67 proliferasyon indeksine sahip olduğu saptandı sırasıyla p0.001, p0.001, p0.001, p0.001, p0.021, p0.039, p0.001 ve p0.001. 55 yaşının altındaki hastalarda tümörlerde multifokalitenin ve meme dokusunun yoğunluğunun daha az olduğu görüldü sırasıyla p0.002, p0.001. 40 yaş altı hastalarda moleküler alt tiplerden luminal B ve TN daha fazla görülürken 55 yaş üzeri hastalarda luminal A alt tipi daha fazla görüldü sırasıyla p0.001, p0.001. Sonuç 40 yaş ile 55 yaş ve üzeri hastalar arasında klinikopatolojik farklılıklar doğrulandı. 40 yaşın altındaki hastalarda meme kanseri için olumsuz prognostik faktörler ortaya çıktı.

Makale detayları

COMPARISON OF THE EFFECTS OF CLINICOPATHOLOGICAL AND RADIOLOGICAL FINDINGS ON SURVIVAL IN WOMEN YOUNGER THAN 40 YEARS AND OLDER THAN 55 YEARS OF AGE WITH BREAST CANCER

Yazarlar:

Buket Altun Özdemir | Servet Kocaöz | Bülent Çomçalı | Mustafa Ömer Yazıcıoğlu | Fırat Canlıkarakaya | Cengiz Ceylan | Birol Korukluoğlu

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Clinical Sciences

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.37-45

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285079

pISSN:

1300-7416

Breast Cancer

lymphovascular invasion

lymph node metastasis

molecular subtype

breast density

Meme Kanseri

Lenfovaskuler invazyon

Lenf nodu metastazı

Moleküler alt tip

Meme yoğunluğu

Sayı

Makale detayları

Yazarlar: Buket Altun Özdemir | Servet Kocaöz | Bülent Çomçalı | Mustafa Ömer Yazıcıoğlu | Fırat Canlıkarakaya | Cengiz Ceylan | Birol Korukluoğlu

Yayıncı: Süleyman Demirel University

Ana Başlıklar: Clinical Sciences

Dergi: Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.37-45

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001285079

pISSN: 1300-7416

Sayı

Yazarlar:

Buket Altun Özdemir | Servet Kocaöz | Bülent Çomçalı | Mustafa Ömer Yazıcıoğlu | Fırat Canlıkarakaya | Cengiz Ceylan | Birol Korukluoğlu

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Clinical Sciences

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.37-45

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285079

pISSN:

1300-7416