The Impact of Increased Platelet Count on Erythrocyte Aggregation in Obese Individuals without Cardiovascular Disease

Serpil Çeçen; Zozan Güleken

Makale detayları

The Impact of Increased Platelet Count on Erythrocyte Aggregation in Obese Individuals without Cardiovascular Disease

Yazarlar:

Serpil Çeçen | Zozan Güleken

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Animal Physiology - Biophysics | Biochemistry and Cell Biology (Other) | Clinical Sciences (Other)

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 2, pp.151-156

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348318

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Introduction: Although obesity raises the risk of cardiovascular illnesses, it is an important issue for public health. Platelets play important role in thrombosis and inflammation, and elevated number of platelets has been noted in obese individuals. Erythrocyte aggregation process involving the clumping of red blood cells, is influenced factors, including platelet activation. To investigate the relationship amongst platelet levels and erythrocyte aggregation in obese individuals. Methods: Anthropometric measurements of obese individuals n101 and non-obese controls n37 were recorded. Erythrocyte aggregation parameters, such as aggregation index AI, aggregation half-time t12, and aggregation amplitude AMP, were measured using a laser-based aggregometer. Platelet counts were determined by automated hematology analyzer. We concerned the anthropometric parameters, platelet counts, and erythrocyte aggregation measures. Results: Obese individuals had significantly higher BMI, fat percentage, fat mass, and fat-free mass versus non-obese controls. In the obese group, Fat mass, increasing fat percentage and BMI, were associated with decreased AMP and t12 values, and increased AI values. Platelet counts were also significantly elevated in the obese group and were inversely correlated with AMP and t12 values. No significant associations were observed between anthropometric parameters, platelet counts, and erythrocyte aggregation measures in the non-obese group. Conclusion: There was strong association between elevated platelet levels and altered erythrocyte aggregation in obese individuals. Findings suggest that obesity-induced increases in platelet count may contribute to increased erythrocyte aggregation, potentially leading to an elevated risk of thrombotic events. Targeting platelet-related pathways may be a promising therapeutic strategy to mitigate cardiovascular complications in obese individuals.

 Introduction: Although obesity raises the risk of cardiovascular illnesses, it is an important issue for public health. Platelets play important role in thrombosis and inflammation, and elevated number of platelets has been noted in obese individuals. Erythrocyte aggregation process involving the clumping of red blood cells, is influenced factors, including platelet activation. To investigate the relationship amongst platelet levels and erythrocyte aggregation in obese individuals. Methods: Anthropometric measurements of obese individuals n101 and non-obese controls n37 were recorded. Erythrocyte aggregation parameters, such as aggregation index AI, aggregation half-time t12, and aggregation amplitude AMP, were measured using a laser-based aggregometer. Platelet counts were determined by automated hematology analyzer. We concerned the anthropometric parameters, platelet counts, and erythrocyte aggregation measures. Results: Obese individuals had significantly higher BMI, fat percentage, fat mass, and fat-free mass versus non-obese controls. In the obese group, Fat mass, increasing fat percentage and BMI, were associated with decreased AMP and t12 values, and increased AI values. Platelet counts were also significantly elevated in the obese group and were inversely correlated with AMP and t12 values. No significant associations were observed between anthropometric parameters, platelet counts, and erythrocyte aggregation measures in the non-obese group. Conclusion: There was strong association between elevated platelet levels and altered erythrocyte aggregation in obese individuals. Findings suggest that obesity-induced increases in platelet count may contribute to increased erythrocyte aggregation, potentially leading to an elevated risk of thrombotic events. Targeting platelet-related pathways may be a promising therapeutic strategy to mitigate cardiovascular complications in obese individuals.

 Introduction: Although obesity raises the risk of cardiovascular illnesses, it is an important issue for public health. Platelets play important role in thrombosis and inflammation, and elevated number of platelets has been noted in obese individuals. Erythrocyte aggregation process involving the clumping of red blood cells, is influenced factors, including platelet activation. To investigate the relationship amongst platelet levels and erythrocyte aggregation in obese individuals. Methods: Anthropometric measurements of obese individuals n101 and non-obese controls n37 were recorded. Erythrocyte aggregation parameters, such as aggregation index AI, aggregation half-time t12, and aggregation amplitude AMP, were measured using a laser-based aggregometer. Platelet counts were determined by automated hematology analyzer. We concerned the anthropometric parameters, platelet counts, and erythrocyte aggregation measures. Results: Obese individuals had significantly higher BMI, fat percentage, fat mass, and fat-free mass versus non-obese controls. In the obese group, Fat mass, increasing fat percentage and BMI, were associated with decreased AMP and t12 values, and increased AI values. Platelet counts were also significantly elevated in the obese group and were inversely correlated with AMP and t12 values. No significant associations were observed between anthropometric parameters, platelet counts, and erythrocyte aggregation measures in the non-obese group. Conclusion: There was strong association between elevated platelet levels and altered erythrocyte aggregation in obese individuals. Findings suggest that obesity-induced increases in platelet count may contribute to increased erythrocyte aggregation, potentially leading to an elevated risk of thrombotic events. Targeting platelet-related pathways may be a promising therapeutic strategy to mitigate cardiovascular complications in obese individuals.

 Amaç: Obezite kardiyovasküler hastalık riskini artmasına neden olan halk sağlığı açısından önemli bir konudur. Trombositler tromboz ve inflamasyonda önemli rol oynamaktadır ve obez bireylerde trombosit sayısında artış kaydedilmiştir. Kırmızı kan hücrelerinin kümelenmesini içeren eritrosit agregasyon süreci, trombosit aktivasyonunu da içeren faktörlerden etkilenmektedir. Bu çalışmada obez bireylerde trombosit düzeyleri ve eritrosit agregasyonu arasındaki ilişki araştırılmıştır. Materyal ve Metot: Obez bireylerin n101 ve obez olmayan kontrollerin n37 antropometrik ölçümleri kaydedilmiştir. Agregasyon indeksi AI, agregasyon yarı zamanı t12 ve agregasyon genliği AMP gibi eritrosit agregasyon parametreleri lazer tabanlı bir agregometre kullanılarak ölçüldü. Trombosit sayıları otomatik hematoloji analizörü ile belirlenmiştir. Antropometrik parametreler, trombosit sayıları ve eritrosit agregasyon ölçümleri yapıldı. Sonuç: Obez bireyler, obez olmayan kontrollere kıyasla önemli ölçüde daha yüksek BMI, yağ yüzdesi, yağ kütlesi ve yağsız kütleye sahipti. Obez grupta, yağ kütlesi, artan yağ yüzdesi ve VKİ, AMP ve t12 değerlerinde azalma ve AI değerlerinde artış ile ilişkiliydi. Trombosit sayıları da obez grupta önemli ölçüde yükselmiş ve AMP ve t12 değerleri ile ters korelasyon göstermiştir. Obez olmayan grupta antropometrik parametreler, trombosit sayıları ve eritrosit agregasyon ölçümleri arasında anlamlı bir ilişki gözlenmemiştir. Tartışma: Obez bireylerde yüksek trombosit seviyeleri ile değişmiş eritrosit agregasyonu arasında güçlü bir ilişki vardı. Bulgular, trombosit sayısında obeziteye bağlı artışların eritrosit agregasyonunun artmasına katkıda bulunabileceğini ve potansiyel olarak trombotik olay riskinin artmasına neden olabileceğini düşündürmektedir. Trombositle ilişkili yolakların hedeflenmesi, obez bireylerde kardiyovasküler komplikasyonların azaltılması için umut verici bir terapötik strateji olabilir.

Makale detayları

The Impact of Increased Platelet Count on Erythrocyte Aggregation in Obese Individuals without Cardiovascular Disease

Yazarlar:

Serpil Çeçen | Zozan Güleken

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Animal Physiology - Biophysics | Biochemistry and Cell Biology (Other) | Clinical Sciences (Other)

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 2, pp.151-156

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348318

pISSN:

2149-9063

Obesity

Anthropometric Measurements

Platelets

Erythrocyte AggregationObezite

Antropometrik Ölçümler

Trombositler

Eritrosit Agregasyonu

Sayı

Makale detayları

Yazarlar: Serpil Çeçen | Zozan Güleken

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Animal Physiology - Biophysics | Biochemistry and Cell Biology (Other) | Clinical Sciences (Other)

Dergi: Meandros Medical And Dental Journal Vol.26 Issue 2, pp.151-156

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348318

pISSN: 2149-9063

Sayı

Yazarlar:

Serpil Çeçen | Zozan Güleken

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Animal Physiology - Biophysics | Biochemistry and Cell Biology (Other) | Clinical Sciences (Other)

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 2, pp.151-156

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348318

pISSN:

2149-9063