Protective Effects of Aronia melanocarpa Extract against Cyclophosphamide-Induced Delayed Toxicity on the Bladder

Hümeyra Çelik; Şeyda Karabörk; Aslıhan Şaylan; Ayhan Çetinkaya

Makale detayları

Protective Effects of Aronia melanocarpa Extract against Cyclophosphamide-Induced Delayed Toxicity on the Bladder

Yazarlar:

Hümeyra Çelik | Şeyda Karabörk | Aslıhan Şaylan | Ayhan Çetinkaya

Yayıncı:

Duzce University

Ana Başlıklar:

Tıbbi Fizyoloji (Diğer)

Dergi:

Sağlık Bilimlerinde Değer Vol.15 Issue 1, pp.36-42

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338340

pISSN:

2792-0542

Anahtar kelimeler:

Özet:

 Aim: Aronia melanocarpa is a red-purple medicinal fruit known for its therapeutic properties in the urinary system by anti-inflammatory effects with high antioxidant content. The aim of the study is to show the supportive effect of Aronia melanocarpa extract delayed toxicity on the bladder induced by cyclophosphamide CYC that an antineoplastic agent. Material and Methods: In the study three groups were constituted control n7, CYCurotoxicity group, n7 and CYCARONIAtreatment group, n7. 100 mgkg CYC intraperitoneally were given to CYC and CYCARONIA groups and waited for 4 weeks to be created delayed toxicity. At the end of the 4 weeks, 200 mgkg Aronia melanocarpa was administered 15 times by oral gavage every other different day to CYCARONIA group 1 month in total. Sacrification was performed and after serum and urine samples were taken, the bladder was released from the sphincter region with curved-tipped forceps. Bladder tissues were investigated histologically. P38 mitogen activated preotein kinase P38 MAPK, total antioxidant TAS and oxidant TOS status were evaluated in serum and urine samples. Results: In histology, histological damage in the bladder continued in the CYC group, while Aronia melanocarpa treatment caused healing in the bladder tissue in the CYCARONIA group. No difference was found between the groups in terms of P38 MAPK, TAS and TOS in serum and urine samples. Conclusion: According to the experimental results, the fact that Aronia melanocarpa extract improves the histological damage caused by CYC in the delayed period, and the serum and urine findings were the same as the controls, brought up the therapeutic effect of Aronia melanocarpa in urotoxicity.

 Aim: Aronia melanocarpa is a red-purple medicinal fruit known for its therapeutic properties in the urinary system by anti-inflammatory effects with high antioxidant content. The aim of the study is to show the supportive effect of Aronia melanocarpa extract delayed toxicity on the bladder induced by cyclophosphamide CYC that an antineoplastic agent. Material and Methods: In the study three groups were constituted control n7, CYCurotoxicity group, n7 and CYCARONIAtreatment group, n7. 100 mgkg CYC intraperitoneally were given to CYC and CYCARONIA groups and waited for 4 weeks to be created delayed toxicity. At the end of the 4 weeks, 200 mgkg Aronia melanocarpa was administered 15 times by oral gavage every other different day to CYCARONIA group 1 month in total. Sacrification was performed and after serum and urine samples were taken, the bladder was released from the sphincter region with curved-tipped forceps. Bladder tissues were investigated histologically. P38 mitogen activated preotein kinase P38 MAPK, total antioxidant TAS and oxidant TOS status were evaluated in serum and urine samples. Results: In histology, histological damage in the bladder continued in the CYC group, while Aronia melanocarpa treatment caused healing in the bladder tissue in the CYCARONIA group. No difference was found between the groups in terms of P38 MAPK, TAS and TOS in serum and urine samples. Conclusion: According to the experimental results, the fact that Aronia melanocarpa extract improves the histological damage caused by CYC in the delayed period, and the serum and urine findings were the same as the controls, brought up the therapeutic effect of Aronia melanocarpa in urotoxicity.

 Aim: Aronia melanocarpa is a red-purple medicinal fruit known for its therapeutic properties in the urinary system by anti-inflammatory effects with high antioxidant content. The aim of the study is to show the supportive effect of Aronia melanocarpa extract delayed toxicity on the bladder induced by cyclophosphamide CYC that an antineoplastic agent. Material and Methods: In the study three groups were constituted control n7, CYCurotoxicity group, n7 and CYCARONIAtreatment group, n7. 100 mgkg CYC intraperitoneally were given to CYC and CYCARONIA groups and waited for 4 weeks to be created delayed toxicity. At the end of the 4 weeks, 200 mgkg Aronia melanocarpa was administered 15 times by oral gavage every other different day to CYCARONIA group 1 month in total. Sacrification was performed and after serum and urine samples were taken, the bladder was released from the sphincter region with curved-tipped forceps. Bladder tissues were investigated histologically. P38 mitogen activated preotein kinase P38 MAPK, total antioxidant TAS and oxidant TOS status were evaluated in serum and urine samples. Results: In histology, histological damage in the bladder continued in the CYC group, while Aronia melanocarpa treatment caused healing in the bladder tissue in the CYCARONIA group. No difference was found between the groups in terms of P38 MAPK, TAS and TOS in serum and urine samples. Conclusion: According to the experimental results, the fact that Aronia melanocarpa extract improves the histological damage caused by CYC in the delayed period, and the serum and urine findings were the same as the controls, brought up the therapeutic effect of Aronia melanocarpa in urotoxicity.

 Amaç: Aronia melanocarpa yüksek antioksidan içeriğiyle antiinflamatuar etkiler göstererek üriner sistemde tedavi edici özellikleri bilinen kırmızı-mor renkli tıbbi bir meyvedir. Çalışmanın amacı antineoplastik bir ajan olan siklofosfamidin CYC mesanede oluşturduğu gecikmiş toksisitede Aronia melanocarpa ekstraktının destekleyici etkisini göstermektir. Gereç ve Yöntemler: Çalışmada kontrol n7, CYC ürotoksisite grubu, n7 ve CYCARONIA tedavi grubu, n7 olacak şekilde üç grup oluşturuldu. CYC ve CYCARONIA gruplarına 100 mgkg CYC intraperitoneal olarak 1 doz verildikten sonra gecikmiş toksisite oluşması için 4 hafta beklenildi. 4 haftanın sonunda Aronia melanocarpa ekstratı oral gavaj ile gün aşırı toplamda 1 ay olacak şekilde 15 kez 200 mgkg dozunda CYCARONIA grubuna verildi. Sakrifikasyonda serum ve idrar örnekleri alındıktan sonra mesane dokusu sfinkter bölgesinden eğimli uçlu forsepsle serbestleştirilerek alındı. Mesane dokusu histolojik olarak değerlendirildi. Enflamatuvar belirteç olan P38 MAP Kinaz, toplam antioksidan TAS ve oksidan TOS durumu serum ve idrarda değerlendirildi. Bulgular: Histolojide CYC grubunda mesanedeki histolojik hasar devam ederken, CYCARONIA grubunda Aronia melanocarpa tedavisi mesane dokusunda iyileşmeye sebep oldu. Serum ve idrar örneklerinde P38 MAPK, TAS ve TOS açısından gruplar arasında fark bulunmadı. Sonuç: Deneysel sonuçlara göre Aronia melanocarpa ekstraktının CYCnin neden olduğu histolojik hasarı geç dönemde iyileştirmesi, serum ve idrar bulgularının kontrollerle aynı olması Aronia melanocarpanın ürotoksisitede terapötik etkisini gündeme getirmiştir.

Makale detayları

Protective Effects of Aronia melanocarpa Extract against Cyclophosphamide-Induced Delayed Toxicity on the Bladder

Yazarlar:

Hümeyra Çelik | Şeyda Karabörk | Aslıhan Şaylan | Ayhan Çetinkaya

Yayıncı:

Duzce University

Ana Başlıklar:

Tıbbi Fizyoloji (Diğer)

Dergi:

Sağlık Bilimlerinde Değer Vol.15 Issue 1, pp.36-42

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338340

pISSN:

2792-0542

cyclophosphamide

Aronia melanocarpa

P38 MAPK

TAS-TOSAronia melanocarpa

P38 MAPK

TAS-TOS

siklofosfamid

Sayı

Makale detayları

Yazarlar: Hümeyra Çelik | Şeyda Karabörk | Aslıhan Şaylan | Ayhan Çetinkaya

Yayıncı: Duzce University

Ana Başlıklar: Tıbbi Fizyoloji (Diğer)

Dergi: Sağlık Bilimlerinde Değer Vol.15 Issue 1, pp.36-42

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001338340

pISSN: 2792-0542

Sayı

Yazarlar:

Hümeyra Çelik | Şeyda Karabörk | Aslıhan Şaylan | Ayhan Çetinkaya

Yayıncı:

Duzce University

Ana Başlıklar:

Tıbbi Fizyoloji (Diğer)

Dergi:

Sağlık Bilimlerinde Değer Vol.15 Issue 1, pp.36-42

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338340

pISSN:

2792-0542