Impact of Inflammatory Bowel Disease on Pulmonary Hemodynamics and Right Ventricular Function: The Role of Pulmonary Pulse Transit Time in Assessing Pulmonary Stiffness and Right Ventricular Function

İlke Erbay; Naile Eriş Güdül; Pelin Aladağ; Güray Ceylan; Selim Aydemir; Ahmet Avcı

Makale detayları

Impact of Inflammatory Bowel Disease on Pulmonary Hemodynamics and Right Ventricular Function: The Role of Pulmonary Pulse Transit Time in Assessing Pulmonary Stiffness and Right Ventricular Function

Yazarlar:

İlke Erbay | Naile Eriş Güdül | Pelin Aladağ | Güray Ceylan | Selim Aydemir | Ahmet Avcı

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Kardiyoloji

Dergi:

Batı Karadeniz Tıp Dergisi Vol.9 Issue 2, pp.255-264

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357730

pISSN:

2822-4302

Anahtar kelimeler:

Özet:

 Aim: Inflammatory bowel disease IBD is a chronic disease with systemic implications, including cardiovascular effects. The aim of this study was to investigate the impact of IBD on right ventricular RV function and pulmonary hemodynamics, focusing on the relationship between pulmonary pulse transit time pPTT and other echocardiographic markers. Material and Methods: Fifty IBD patients and 50 matched healthy controls underwent echocardiographic evaluation to assess RV function, including parameters such as RV myocardial performance index RVMPI, RV ejection fraction RV EF and tricuspid annular plane systolic excursion TAPSE. Pulmonary hemodynamics were assessed by pPTT and pulmonary arterial stiffness PAS. Statistical analyses explored the associations between IBD and these echocardiographic parameters. Results: No differences in systolic pulmonary artery pressure sPAP or TAPSE were observed between the groups. PAS was increased and pPTT was shortened in IBD patients compared to controls. pPTT correlated with PAS, IBD duration, RV EF, RV fractional area change RVFAC, TAPSE, tricuspid S, RVMPI and C-reactive protein CRP. pPTT was an independent predictor of PAS p  0.001. Conclusion: IBD patients show impaired RV function and increased pulmonary stiffness. pPTT may serve as a practical marker for early detection of pulmonary vascular changes in IBD, replacing PAS for hemodynamic assessment.

 Aim: Inflammatory bowel disease IBD is a chronic disease with systemic implications, including cardiovascular effects. The aim of this study was to investigate the impact of IBD on right ventricular RV function and pulmonary hemodynamics, focusing on the relationship between pulmonary pulse transit time pPTT and other echocardiographic markers. Material and Methods: Fifty IBD patients and 50 matched healthy controls underwent echocardiographic evaluation to assess RV function, including parameters such as RV myocardial performance index RVMPI, RV ejection fraction RV EF and tricuspid annular plane systolic excursion TAPSE. Pulmonary hemodynamics were assessed by pPTT and pulmonary arterial stiffness PAS. Statistical analyses explored the associations between IBD and these echocardiographic parameters. Results: No differences in systolic pulmonary artery pressure sPAP or TAPSE were observed between the groups. PAS was increased and pPTT was shortened in IBD patients compared to controls. pPTT correlated with PAS, IBD duration, RV EF, RV fractional area change RVFAC, TAPSE, tricuspid S, RVMPI and C-reactive protein CRP. pPTT was an independent predictor of PAS p  0.001. Conclusion: IBD patients show impaired RV function and increased pulmonary stiffness. pPTT may serve as a practical marker for early detection of pulmonary vascular changes in IBD, replacing PAS for hemodynamic assessment.

 Aim: Inflammatory bowel disease IBD is a chronic disease with systemic implications, including cardiovascular effects. The aim of this study was to investigate the impact of IBD on right ventricular RV function and pulmonary hemodynamics, focusing on the relationship between pulmonary pulse transit time pPTT and other echocardiographic markers. Material and Methods: Fifty IBD patients and 50 matched healthy controls underwent echocardiographic evaluation to assess RV function, including parameters such as RV myocardial performance index RVMPI, RV ejection fraction RV EF and tricuspid annular plane systolic excursion TAPSE. Pulmonary hemodynamics were assessed by pPTT and pulmonary arterial stiffness PAS. Statistical analyses explored the associations between IBD and these echocardiographic parameters. Results: No differences in systolic pulmonary artery pressure sPAP or TAPSE were observed between the groups. PAS was increased and pPTT was shortened in IBD patients compared to controls. pPTT correlated with PAS, IBD duration, RV EF, RV fractional area change RVFAC, TAPSE, tricuspid S, RVMPI and C-reactive protein CRP. pPTT was an independent predictor of PAS p  0.001. Conclusion: IBD patients show impaired RV function and increased pulmonary stiffness. pPTT may serve as a practical marker for early detection of pulmonary vascular changes in IBD, replacing PAS for hemodynamic assessment.

 Amaç: İnflamatuvar bağırsak hastalığı İBH, sistemik etkileri olan kronik bir hastalık olup kardiyovasküler sistemi de etkileyebilmektedir. Bu çalışmada, İBHnin sağ ventrikül SV fonksiyonları ve pulmoner hemodinami üzerindeki etkileri araştırılmış; özellikle pulmoner pulse transit time pPTT ile diğer ekokardiyografik göstergeler arasındaki ilişki incelenmiştir. Gereç ve Yöntemler: Çalışmaya 50 İBH hastası ile yaş ve cinsiyet açısından eşleştirilmiş 50 sağlıklı kontrol birey dahil edildi. Tüm katılımcılarda ekokardiyografi ile SV fonksiyonları değerlendirildi. Bu kapsamda SV miyokardiyal performans indeksi SVMPI, SV ejeksiyon fraksiyonu SV EF ve triküspit anüler düzlem sistolik ekskursiyonu TAPSE gibi parametreler analiz edildi. Pulmoner hemodinamik değerlendirme ise pPTT ve pulmoner arteriyel stiffness PAS ölçümleri ile yapıldı. İBH ile bu ekokardiyografik parametreler arasındaki ilişkiler istatistiksel olarak incelendi. Bulgular: Gruplar arasında sistolik pulmoner arter basıncı sPAP ve TAPSE açısından anlamlı fark bulunmazken, İBH hastalarında PAS düzeyleri belirgin şekilde artmış, pPTT süreleri ise anlamlı olarak kısalmıştı. pPTT; PAS, İBH süresi, SV EF, SV fraksiyonel alan değişimi SVFAC, TAPSE, triküspit S, SVMPI ve C-reaktif protein CRP ile anlamlı korelasyon gösterdi. Ayrıca, pPTTnin PAS üzerinde bağımsız bir belirleyici olduğu saptandı p  0,001. Sonuç: İBH hastalarında sağ ventrikül fonksiyonlarında bozulma ve pulmoner damar sertliğinde artış gözlenmektedir. pPTT, pulmoner vasküler değişikliklerin erken tanısında pratik ve erişilebilir bir belirteç olarak PASın yerini alabilecek potansiyele sahiptir.

Makale detayları

Impact of Inflammatory Bowel Disease on Pulmonary Hemodynamics and Right Ventricular Function: The Role of Pulmonary Pulse Transit Time in Assessing Pulmonary Stiffness and Right Ventricular Function

Yazarlar:

İlke Erbay | Naile Eriş Güdül | Pelin Aladağ | Güray Ceylan | Selim Aydemir | Ahmet Avcı

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Kardiyoloji

Dergi:

Batı Karadeniz Tıp Dergisi Vol.9 Issue 2, pp.255-264

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357730

pISSN:

2822-4302

Inflammatory bowel disease

right ventricular function

pulmonary pulse transit time

pulmonary arterial stiffnessİnflamatuvar bağırsak hastalığı

sağ ventrikül fonksiyonu

pulmoner pulse transit time

pulmoner arteriyel stiffness

Sayı

Makale detayları

Yazarlar: İlke Erbay | Naile Eriş Güdül | Pelin Aladağ | Güray Ceylan | Selim Aydemir | Ahmet Avcı

Yayıncı: Zonguldak Bulent Ecevit University

Ana Başlıklar: Kardiyoloji

Dergi: Batı Karadeniz Tıp Dergisi Vol.9 Issue 2, pp.255-264

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357730

pISSN: 2822-4302

Sayı

Yazarlar:

İlke Erbay | Naile Eriş Güdül | Pelin Aladağ | Güray Ceylan | Selim Aydemir | Ahmet Avcı

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Kardiyoloji

Dergi:

Batı Karadeniz Tıp Dergisi Vol.9 Issue 2, pp.255-264

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357730

pISSN:

2822-4302