Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits

İsmail ÇELİK; Vedat TÜRKOĞLU; Esref YEĞİN

Makale detayları

Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits

Yazarlar:

İsmail ÇELİK | Vedat TÜRKOĞLU | Esref YEĞİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2000 Vol.24 Issue 2, pp.149-152

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000771747

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Anahtar kelimeler:

Özet:

 

Hypothyroidism is commonly associated with hyperlipidemia. The aim of this study was to investigate the effect of  Propylthiouracil-induced hypothyroidism on the plasma lipid profile in rabbits. This investigation was performed on male, white New  Zealand ( Oryctolagus cuniculus huxley) rabbits. Twenty rabbits were used; each of the two groups (hypothyroidism and control)  consisted of ten animals. Hypothyroidism was induced by oral administration of Propylthiouracil 50 mg.kg -1 for three weeks.  The mean values of Triiodothyronine (T 3 ), thyroxine (T 4 ), free T 3 (FT 3 ) and free T 4 (FT 4 ) were 121.7±32.7 ng/d1, 1.81±0.60 µg/dl,  2.36±9b92 ng/dl and 0.43±0.22 p mol/dl in the control group, and 88.4±19.2 ng/dl, 1.15±0.37 µg/dl, 1.48±0.44 ng/dl and  0.18±0.11p mol/dl in the hypothyroidism group, respectively (p.

 

Hypothyroidism is commonly associated with hyperlipidemia. The aim of this study was to investigate the effect of  Propylthiouracil-induced hypothyroidism on the plasma lipid profile in rabbits. This investigation was performed on male, white New  Zealand ( Oryctolagus cuniculus huxley) rabbits. Twenty rabbits were used; each of the two groups (hypothyroidism and control)  consisted of ten animals. Hypothyroidism was induced by oral administration of Propylthiouracil 50 mg.kg -1 for three weeks.  The mean values of Triiodothyronine (T 3 ), thyroxine (T 4 ), free T 3 (FT 3 ) and free T 4 (FT 4 ) were 121.7±32.7 ng/d1, 1.81±0.60 µg/dl,  2.36±9b92 ng/dl and 0.43±0.22 p mol/dl in the control group, and 88.4±19.2 ng/dl, 1.15±0.37 µg/dl, 1.48±0.44 ng/dl and  0.18±0.11p mol/dl in the hypothyroidism group, respectively (p.

Makale detayları

Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits

Yazarlar:

İsmail ÇELİK | Vedat TÜRKOĞLU | Esref YEĞİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2000 Vol.24 Issue 2, pp.149-152

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000771747

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Hypothyroidism

lipid

rabbit.

Sayı

Makale detayları

Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits

Yazarlar: İsmail ÇELİK | Vedat TÜRKOĞLU | Esref YEĞİN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2000 Vol.24 Issue 2, pp.149-152

Belge Tipi: Makale

Yayın Tarihi: 1/2000

Belge Dili: Türkçe

Document ID (Org No.): 2000771747

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Hypothyroidism

lipid

rabbit.

Sayı

Yazarlar:

İsmail ÇELİK | Vedat TÜRKOĞLU | Esref YEĞİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2000 Vol.24 Issue 2, pp.149-152

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000771747

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128