Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

Esin AVCI; Nazlı ÇİL; Hülya AYBEK; Zafer AYBEK

doi:https://doi.org/10.30621/jbachs.2020.794

Makale detayları

Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

Yazarlar:

Esin AVCI | Nazlı ÇİL | Hülya AYBEK | Zafer AYBEK

Yayıncı:

Dokuz Eylul University

Dergi:

Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 2, pp.96-103

Belge Tipi:

Makale

Yayın Tarihi:

5/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000493487

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.2020.794

Özet:

 

Objective: Chronic kidney disease  CKD  is still common worldwide. We investigated the effect of two different doses of vitamin E with selenium   Se  administration to prevent CKD leads to renal damage via unilateral ureteral obstruction  UUO .  Material and Methods: Thirty-two female Wistar Albino rats were divided into four groups; a sham group  left UUO+no medication ; left  UUO with no treatment, left UUO treated with 100 mg/kg dose Vitamin E+Se  RPVE+Se  and left UUO treated with 1000 mg/kg Vitamin E+Se   HDVE+Se  mixture. All rats subjected during 14 days and killed humanely. Malondialdehyde  MDA , superoxide dismutase  SOD , glutathione   GSH , levels were determined in kidney tissue, whereas total antioxidant status  TAS , total oxidant status  TOS  and DNA damage marker  8-hydroxy-2-deoxyguanosine  8-OHdG  in serum. Histologic examination were also done.  Results: The unilateral ureteral obstruction model increased MDA  p.

Makale detayları

Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

Yazarlar: Esin AVCI | Nazlı ÇİL | Hülya AYBEK | Zafer AYBEK

Yayıncı: Dokuz Eylul University

Dergi: Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 2, pp.96-103

Belge Tipi: Makale

Yayın Tarihi: 5/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000493487

Sıklık: Üç Yıllık

eISSN: 2564-7288

DOI: https://doi.org/10.30621/jbachs.2020.794

Sayı

Yazarlar:

Esin AVCI | Nazlı ÇİL | Hülya AYBEK | Zafer AYBEK

Yayıncı:

Dokuz Eylul University

Dergi:

Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 2, pp.96-103

Belge Tipi:

Makale

Yayın Tarihi:

5/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000493487

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.2020.794