Investigation of the relationship between ischemic stroke and endothelial nitric oxide synthase gene polymorphisms [G894T, intron 4 VNTR and T786C]

Süleyman Ömer ANLIAÇIK; Osman Serhat TOKGÖZ; Ayşegül ZAMANİ; Mahmut Selman YILDIRIM; Mehmet Sinan İYİSOY

Makale detayları

Investigation of the relationship between ischemic stroke and endothelial nitric oxide synthase gene polymorphisms [G894T, intron 4 VNTR and T786C]

Yazarlar:

Süleyman Ömer ANLIAÇIK | Osman Serhat TOKGÖZ | Ayşegül ZAMANİ | Mahmut Selman YILDIRIM | Mehmet Sinan İYİSOY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.589-594

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750205

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim:  We  aimed  to  investigate  the  associations  between  endothelial  nitric  oxide  synthase(eNOS)  gene  polymorphisms  [G894T (rs1799983)], intron 4 (27-bpTR) variable number tandem repeat (VNTR) and T786C (rs2070744), and ischemic stroke in the Anatolian population.Materials and methods: This case-control study included 112 patients with "stroke of undetermined etiology" and 160 controls. Real-time polymerase chain reaction (RT-PCR) analysis was used to analyze these polymorphisms. Between-group frequencies of alleles and genotypes were compared using binary logistic regression analysis.Results:  No  significant  difference  was  observed  between  the  two  groups  in  terms  of  the  genotype  and  allele  distributions  of  the  eNOS G894T (rs1799983) polymorphism (P > 0.05). The a alleles and the 4b/a and 4a/a genotypes of the intron 4 (27-bpTR) VNTR polymorphism  had  significantly  higher  frequencies  in  the  patient  group  than  in  the  control  group  (OR:  2.715,  P  <  0.001;  OR:  3.396,  P < 0.001; OR: 10.631, P = 0.016, respectively). On the contrary, the TC genotype and C alleles of the T786C (rs2070744) polymorphism had a significantly lower frequency in the patient group than in the control group (OR: 0.244, P < 0.001, OR: 0.605, P = 0.006, respectively).Conclusion: Our findings indicate that the eNOS G894T and T786C [rs2070744] polymorphisms are not associated with the risk of ischemic stroke, whereas the intron 4 [27-bpTR] VNTR may be a risk factor in the Anatolian population.

Makale detayları

Investigation of the relationship between ischemic stroke and endothelial nitric oxide synthase gene polymorphisms [G894T, intron 4 VNTR and T786C]

Yazarlar: Süleyman Ömer ANLIAÇIK | Osman Serhat TOKGÖZ | Ayşegül ZAMANİ | Mahmut Selman YILDIRIM | Mehmet Sinan İYİSOY

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.589-594

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000750205

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Süleyman Ömer ANLIAÇIK | Osman Serhat TOKGÖZ | Ayşegül ZAMANİ | Mahmut Selman YILDIRIM | Mehmet Sinan İYİSOY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.589-594

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750205

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144