Development and Validation of RP-HPLC Method for the Determination of Dexrabeprazole Sodium

Semra YILMAZER KESKİN; Ebru Nurdan ŞENTÜRK; Cihansel UNLU

doi:https://doi.org/10.16984/saufenbilder.999458

Makale detayları

Development and Validation of RP-HPLC Method for the Determination of Dexrabeprazole Sodium

Yazarlar:

Semra YILMAZER KESKİN | Ebru Nurdan ŞENTÜRK | Cihansel UNLU

Ana Başlıklar:

Astronomi ve ilgili bilimler

Dergi:

Sakarya University Journal of Science 2021 Vol.25 Issue 6, pp.1427-1431

Belge Tipi:

Makale

Yayın Tarihi:

12/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000556051

DOI:

https://doi.org/10.16984/saufenbilder.999458

Özet:

 

A rapid and simple liquid chromatographic method was developed for the quantitative determination of dexrabeprazole sodium in the tablet dosage form. The reverse-phase chromatographic analysis was carried out by using a C-18 column. The acetonitrile-phosphate buffer mixture was used as the mobile phase. The obtained retention time was 4.33∓0.02 min. by using 50:50 (v:v) acetonitrile:phosphate buffer(pH 7) and 1.0 mL/min. flow rate. Quantification of the analyte was based on measuring the peaks areas at 272 nm. The analytical performance of the developed RP-HPLC method was validated with respect to accuracy, precision, linearity, stability, and robustness. The obtained linearity range was 77-143 mg/L and the correlation coefficient was 0.9989. The obtained LOD and LOQ values were 0.010 mg/L and 0.034 mg/L, respectively.

Makale detayları

Development and Validation of RP-HPLC Method for the Determination of Dexrabeprazole Sodium

Yazarlar: Semra YILMAZER KESKİN | Ebru Nurdan ŞENTÜRK | Cihansel UNLU

Ana Başlıklar: Astronomi ve ilgili bilimler

Dergi: Sakarya University Journal of Science 2021 Vol.25 Issue 6, pp.1427-1431

Belge Tipi: Makale

Yayın Tarihi: 12/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000556051

DOI: https://doi.org/10.16984/saufenbilder.999458

Sayı

Yazarlar:

Semra YILMAZER KESKİN | Ebru Nurdan ŞENTÜRK | Cihansel UNLU

Ana Başlıklar:

Astronomi ve ilgili bilimler

Dergi:

Sakarya University Journal of Science 2021 Vol.25 Issue 6, pp.1427-1431

Belge Tipi:

Makale

Yayın Tarihi:

12/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000556051

DOI:

https://doi.org/10.16984/saufenbilder.999458